Exact norm-conserving stochastic time-dependent Hartree-Fock

We derive an exact single-body decomposition of the time-dependent Schroedinger equation for N pairwise-interacting fermions. Each fermion obeys a stochastic time-dependent norm-preserving wave equation. As a first test of the method we calculate the low energy spectrum of Helium. An extension of the method to bosons is outlined.Comment: 21 pages, 3 figures, LaTeX fil

Which anticoagulant is safest for frail elderly patients with nonvalvular A-fib?

Consider apixaban, which demonstrated a lower adverse event (AE) rate than warfarin regardless of frailty status, for anticoagulation treatment of older patients with nonvalvular atrial fibrillation (AF); by comparison, AE rates for dabigatran and rivaroxaban were lower vs warfarin only among nonfrail individuals.J. Scott Earwood, MD; Justin L. Wilkie, MD; Jennifer L. Fernandez-Vasquez, MD, (Dwight David Eisenhower Army Medical Center, Fort Gordon)Includes bibliographical reference

Suppression of decoherence via strong intra-environmental coupling

We examine the effects of intra-environmental coupling on decoherence by constructing a low temperature spin--spin-bath model of an atomic impurity in a Debye crystal. The impurity interacts with phonons of the crystal through anti-ferromagnetic spin-spin interactions. The reduced density matrix of the central spin representing the impurity is calculated by dynamically integrating the full Schroedinger equation for the spin--spin-bath model for different thermally weighted eigenstates of the spin-bath. Exact numerical results show that increasing the intra-environmental coupling results in suppression of decoherence. This effect could play an important role in the construction of solid state quantum devices such as quantum computers.Comment: 4 pages, 3 figures, Revtex fil

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins

Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity. From this screen we identified three structurally related 5-aminopyrazine compounds (XMD7-1, -2 and -27) that inhibited HCMV replication in virus yield reduction assays at low micromolar concentrations. Kinase selectivity assays indicated that each compound was a kinase inhibitor capable of inhibiting a range of cellular protein kinases. Western blotting and RNA sequencing demonstrated that treatment of infected cells with XMD7 compounds resulted in a defect in the production of the major HCMV transcriptional transactivator IE2 proteins (IE2-86, IE2-60 and IE2-40) and an overall reduction in transcription from the viral genome. However, production of certain viral proteins was not compromised by treatment with XMD7 compounds. Thus, these novel anti-HCMV compounds likely inhibited transcription from the viral genome and suppressed production of a subset of viral proteins by inhibiting IE2 protein production

“some kind of thing it aint us but yet its in us”: David Mitchell, Russell Hoban, and metafiction after the millennium

This article appraises the debt that David Mitchell’s Cloud Atlas owes to the novels of Russell Hoban, including, but not limited to, Riddley Walker. After clearly mapping a history of Hoban’s philosophical perspectives and Mitchell’s inter-textual genre-impersonation practice, the article assesses the degree to which Mitchell’s metatextual methods indicate a nostalgia for by-gone radical aesthetics rather than reaching for new modes of its own. The article not only proposes several new backdrops against which Mitchell’s novel can be read but also conducts the first in-depth appraisal of Mitchell’s formal linguistic replication of Riddley Walker

Σύνθεση ιοντικών υγρών και βαθέων ευτηκτικών διαλυτών και εφαρμογή τους στο διαχωρισμό του αζεοτροπικού μίγματος αιθανόλης/νερού

Productivity in temperate tree crops such as apple has been lifted several-fold by research focusing on optimising a combination of canopy components including light relations, vigour control, tree architecture and crop load. This paper outlines the research behind the Small Tree-High Productivity Initiative (STHPI), which is focused on improving productivity of mango, avocado and macadamia. Preliminary results from work we are undertaking for each of the above canopy components in mango will be outlined. A rootstock screening trial to identify vigour-managing, high-productivity rootstocks is being undertaken, and we present a comparison of the best-performing low-medium vigour rootstock varieties compared with control 'Kensington Pride' (KP) rootstock at 6 months old. Comparisons between 'Keitt', 'NMBP 1243' and 'Calypso' scion cultivars with regard to tree diameter, height and canopy growth at different orchard densities and training systems will also be presented. Preliminary results from an orchard light-relations study indicate that mango yields continued to increase with light interception up to 50%, and reached a maximum of 20-30 t ha at 68% light interception in KP trees approximately 25 years old. In a crop load trial, inflorescence thinning in a 'Calypso' orchard did not significantly reduce yields when up to 90% of inflorescences were removed, but did when 95% of inflorescences were removed, as trees were unable to compensate by adjusting fruit set, size and yield. Inflorescence thinning beyond 80% increased the number of fruit set per panicle, and thinning up to and including 90% of inflorescences increased fruit weight from 340 g to >400 g per fruit. This project is still in its initial stages; however, early indications suggest there may be opportunities to improve early orchard yields through optimising light interception in an orchard's life, potentially through the use of higher densities, and that rootstocks and tree training methods, once identified, may help in the management of vigour. It is also hoped to obtain a better understanding of how crop load influences the balance between vegetative growth, flowering, fruiting, alternate bearing and fruit quality

Stochastic time-dependent current-density functional theory: a functional theory of open quantum systems

The dynamics of a many-body system coupled to an external environment represents a fundamentally important problem. To this class of open quantum systems pertains the study of energy transport and dissipation, dephasing, quantum measurement and quantum information theory, phase transitions driven by dissipative effects, etc. Here, we discuss in detail an extension of time-dependent current-density-functional theory (TDCDFT), we named stochastic TDCDFT [Phys. Rev. Lett. {\bf 98}, 226403 (2007)], that allows the description of such problems from a microscopic point of view. We discuss the assumptions of the theory, its relation to a density matrix formalism, and the limitations of the latter in the present context. In addition, we describe a numerically convenient way to solve the corresponding equations of motion, and apply this theory to the dynamics of a 1D gas of excited bosons confined in a harmonic potential and in contact with an external bath.Comment: 17 pages, 7 figures, RevTex4; few typos corrected, a figure modifie