Can cosmic strangelets reach the earth?

The mechanism for the propagation of strangelets with low baryon number through the atmosphere of the Earth has been explored. It has been shown that under suitable initial conditions, such strangelets may indeed reach depths near mountain altitudes with mass numbers and charges close to the observed values in cosmic ray experiments.Comment: RevTeX text, with 3 encoded eps figures. To appear in Physical Review Letter

Modified Hagedorn formula including temperature fluctuation - Estimation of temperatures at RHIC experiments -

We have systematically estimated the possible temperatures obtained from an analysis of recent data on $p_t$ distributions observed at RHIC experiments. Using the fact that observed $p_t$ distributions cannot be described by the original Hagedorn formula in the whole range of transverse momenta (in particular above 6 GeV/c), we propose a modified Hagedorn formula including temperature fluctuation. We show that by using it we can fit $p_t$ distributions in the whole range and can estimate consistently the relevant temperatures, including their fluctuations.Comment: Some misprints corrected, references updated. To be published in Eur. Phys. J. C (2006

Scale-free download network for publications

The scale-free power-law behavior of the statistics of the download frequency of publications has been, for the first time, reported. The data of the download frequency of publications are taken from a well-constructed web page in the field of economic physics (http://www.unifr.ch/econophysics/). The Zipf-law analysis and the Tsallis entropy method were used to fit the download frequency. It was found that the power-law exponent of rank-ordered frequency distribution is $\gamma \sim 0.38 \pm 0.04$ which is consistent with the power-law exponent $\alpha \sim 3.37 \pm 0.45$ for the cumulated frequency distributions. Preferential attachment model of Barabasi and Albert network has been used to explain the download network.Comment: 3 pages, 2 figure

Nonextensive thermal sources of cosmic rays?

The energy spectrum of cosmic rays (CR) exhibits power-like behavior with a very characteristic "knee" structure. We consider a possibility that such a spectrum could be generated by some specific nonstatistical temperature fluctuations in the source of CR with the "knee" structure reflecting an abrupt change of the pattern of such fluctuations. This would result in a generalized nonextensive statistical model for the production of CR. The possible physical mechanisms leading to these effects are discussed together with the resulting chemical composition of the CR, which follows the experimentally observed abundance of nuclei.Comment: 16 pages, 3 figures, rewritten and updated version, to be published in Centr. Eur. J. Phy

Shaping the Phase of a Single Photon

While the phase of a coherent light field can be precisely known, the phase of the individual photons that create this field, considered individually, cannot. Phase changes within single-photon wave packets, however, have observable effects. In fact, actively controlling the phase of individual photons has been identified as a powerful resource for quantum communication protocols. Here we demonstrate the arbitrary phase control of a single photon. The phase modulation is applied without affecting the photon's amplitude profile and is verified via a two-photon quantum interference measurement, which can result in the fermionic spatial behaviour of photon pairs. Combined with previously demonstrated control of a single photon's amplitude, frequency, and polarisation, the fully deterministic phase shaping presented here allows for the complete control of single-photon wave packets.Comment: 4 pages, 4 figure

The Reliability of Parafoveal Cone Density Measurements

Background Adaptive optics scanning light ophthalmoscopy (AOSLO) enables direct visualisation of the cone mosaic, with metrics such as cone density and cell spacing used to assess the integrity or health of the mosaic. Here we examined the interobserver and inter-instrument reliability of cone density measurements. Methods For the interobserver reliability study, 30 subjects with no vision-limiting pathology were imaged. Three image sequences were acquired at a single parafoveal location and aligned to ensure that the three images were from the same retinal location. Ten observers used a semiautomated algorithm to identify the cones in each image, and this was repeated three times for each image. To assess inter-instrument reliability, 20 subjects were imaged at eight parafoveal locations on one AOSLO, followed by the same set of locations on the second AOSLO. A single observer manually aligned the pairs of images and used the semiautomated algorithm to identify the cones in each image. Results Based on a factorial study design model and a variance components model, the interobserver study\u27s largest contribution to variability was the subject (95.72%) while the observer\u27s contribution was only 1.03%. For the inter-instrument study, an average cone density intraclass correlation coefficient (ICC) of between 0.931 and 0.975 was calculated. Conclusions With the AOSLOs used here, reliable cone density measurements can be obtained between observers and between instruments. Additional work is needed to determine how these results vary with differences in image quality

Some forgotten features of the Bose Einstein Correlations

Notwithstanding the visible maturity of the subject of Bose-Einstein Correlations (BEC), as witnessed nowadays, we would like to bring to ones attention two points, which apparently did not received attention they deserve: the problem of the choice of the form of $C_2(Q)$ correlation function when effects of partial coherence of the hadronizing source are to be included and the feasibility to model effects of Bose-Einstein statistics, in particular the BEC, by direct numerical simulations.Comment: Talk delivered by G.Wilk at the International Workshop {\it Relativistic Nuclear Physics: from Nuclotron to LHC energies}, Kiev, June 18-22, 2007, Ukraine; misprints correcte

A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study

The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 Framingham Heart Study participants to identify single-nucleotide polymorphisms (SNPs) associated with the FEV1/FVC ratio, analyzed as a percent of the predicted value. Identified SNPs were examined in an independent set of 835 Family Heart Study participants enriched for airflow obstruction. Four SNPs in tight linkage disequilibrium on chromosome 4q31 were associated with the percent predicted FEV1/FVC ratio with p-values of genome-wide significance in the Framingham sample (best p-value = 3.6e-09). One of the four chromosome 4q31 SNPs (rs13147758; p-value 2.3e-08 in Framingham) was genotyped in the Family Heart Study and produced evidence of association with the same phenotype, percent predicted FEV1/FVC (p-value = 2.0e-04). The effect estimates for association in the Framingham and Family Heart studies were in the same direction, with the minor allele (G) associated with higher FEV1/FVC ratio levels. Results from the Family Heart Study demonstrated that the association extended to FEV1 and dichotomous airflow obstruction phenotypes, particularly among smokers. The SNP rs13147758 was associated with the percent predicted FEV1/FVC ratio in independent samples from the Framingham and Family Heart Studies producing a combined p-value of 8.3e-11, and this region of chromosome 4 around 145.68 megabases was associated with COPD in three additional populations reported in the accompanying manuscript. The associated SNPs do not lie within a gene transcript but are near the hedgehog-interacting protein (HHIP) gene and several expressed sequence tags cloned from fetal lung. Though it is unclear what gene or regulatory effect explains the association, the region warrants further investigation

Can Centauros or Chirons be the first observations of evaporating mini black holes?

We argue that the signals expected from the evaporation of mini black holes - predicted in TeV-scale gravity models with large extra dimensions, and possibly produced in ultra high energy collisions in the atmosphere - are quite similar to the characteristics of the Centauro events, an old mystery of cosmic-ray physics.Comment: 14 pages, LaTeX, one Table, uses rotate.sty and rotcapt.sty. References added, typos corrected, footnotes moved into the tex

The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro

Tumour necrosis factor-α (TNF-α) has been implicated as an important inflammatory mediator. In vitro, TNF-α is reported to activate human polymorphonuclear neutrophils (PMN), inducing responses such as phagocytic activity, degranulation and oxidative metabolism. Biological responses to TNF-α are initiated by its binding to specific cell surface receptors, and various studies have shown that the major TNF receptor species on PMN is the 75 kDa receptor. To verify the suggestion that the receptor binding domain includes the region close to the N-terminus of the TNF-α molecule, four TNF-α derivatives termed muteins were constructed, using a synthetic cDNA fragment substituting the N-terminal 3–7 selected hydrophilic or hydrophobic amino acids in the original TNF-α genomic DNA. Binding of muteins to PMN was assessed using monoclonal antibodies recognizing either the 55 kDa (p55) or the 75 kDa (p75) TNF receptor subtypes. Blocking by muteins of anti-p75 antibody binding to PMN was as expected from their N-terminal amino acid composition and hydrophilic properties. Hydrophilic muteins competed well with anti-TNF receptor antibodies for binding to the p75 receptor. In contrast, hydrophobic muteins were unable to block anti-p75 binding. Similarly, degranulation, chemiluminescence or enhancement of the PMN response to specific stimuli by the muteins correlated with the hydrophilic properties of the muteins. The significance of these observations in relation to the molecular structure of TNF-α is discussed