The Association Between Child Abuse and Attempted Suicide in Hong Kong

Children are the cornerstone of the community as well as the future of society. Child abuse and suicide among the young population is a serious and prevalent problem. Through a number of survey studies undertaken in other countries including Canada, United States, and Australia, researchers demonstrated that child abuse was related to suicidal behavior. However, this association had not been examined in Hong Kong. However, the number of hospital admissions for child abuse in Hong Kong had increased from 15.6 to 61.9 per 100,000 between 1995 and 2015 and 3.7% of child abuse cases had previously recorded suicide attempts. This study aimed to identify the association between child abuse and suicide attempts compared with influenza infection using electronic hospital admission records. From January 1, 1995 to July 31, 2016, patients with admission age \u3c 18 years with the diagnosis of child abuse or influenza infection were included in this study (n = 54,256). The study also retrieved data on suicide attempt hospital admissions after the first hospital admission from the database. The study results demonstrate that the adjusted hazard ratio indicated that at any given point of time, child abuse subjects had 4.79 times higher risk (95% CI 3.88 to 5.92) of attempting suicide compared with influenza infected subjects. The hazard ratio for sexual abuse and physical abuse compared with the influenza infected group was 6.48 (95% CI 4.56 to 9.19) and 4.83 (95% CI 3.67 to 6.34). Study results indicated that there was a significant association between child abuse and suicide attempts in Hong Kong. If confirmed, the study results may inform policy and interventions to reduce child abuse and consequently child suicide attempts

Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions.

BackgroundOsteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles. OPN undergoes extensive post-translational modifications, including polymerization and proteolytic fragmentation, which alters its biologic activity. Recent studies suggest that OPN may contribute to the pathogenesis of asthma.MethodologyTo determine whether secreted OPN (sOPN) is polymerized in human airways and whether it is qualitatively different in asthma, we used immunoblotting to examine sOPN in bronchoalveolar lavage (BAL) fluid samples from 12 healthy and 21 asthmatic subjects (and in sputum samples from 27 healthy and 21 asthmatic subjects). All asthmatic subjects had mild to moderate asthma and abstained from corticosteroids during the study. Furthermore, we examined the relationship between airway sOPN and cellular inflammation.Principal findingsWe found that sOPN in BAL fluid and sputum exists in polymeric, monomeric, and cleaved forms, with most of it in polymeric form. Compared to healthy subjects, asthmatic subjects had proportionately less polymeric sOPN and more monomeric and cleaved sOPN. Polymeric sOPN in BAL fluid was associated with increased alveolar macrophage counts in airways in all subjects.ConclusionsThese results suggest that sOPN in human airways (1) undergoes extensive post-translational modification by polymerization and proteolytic fragmentation, (2) is more fragmented and less polymerized in subjects with mild to moderate asthma, and (3) may contribute to recruitment or survival of alveolar macrophages

Dynamic buffer tuning: an ambience-intelligent way for digital ecosystem success

Ambient intelligence is an important element for the success of digital ecosystems which usually are made up of many collaborating distributed nodes. The operations of these nodes affect one another as chain reactions. When one node had failed, it could bring down the whole ecosystem. Dynamic buffer tuning is an ambience-intelligent mechanism because it has the ability to sense the ambient changes and then makes necessary proactive changes on the fly to avoid buffer overflow. As a result the end-to-end communication channel is more dependable, leading to shorter response time and happier clients. Therefore, dynamic buffer tuning should be generally beneficial to digital ecosystem system performance. In this paper we demonstrate this point by using the FLC (Fuzzy Logic Controller) dynamic buffer tuner to quicken the pervasive medical consultation response of the TCM (Traditional Chinese Medicine) Pervasive Digital HealthCare System as an example

Scanning tunnelling miscroscopy/spectroscopy and X-ray absorption spectroscopy studies of Co adatoms and anoislands on highly oriented pyrolytic graphite

In this paper, the scanning tunneling microscopy, scanning tunneling spectroscopy and X-ray absorption spectroscopy of cobalt adatoms and nanoislands were studied on a highly oriented pyrolytic graphite. Local electronic structure were observed by STS.\ud \u

Singapore's Venture into the Gulf: Undiscovered Treasure or Empty Pot?

Singapore: a country synonymous with business efficiency, strict laws and a reputation that belies its miniscule size. Its state-enterprise network and attempts at grafting “Singapore-styled†investment enclaves onto foreign locales often receive attention from the international community. These stateengineered projects are premised on the exportability of Singapore’s state credibility, systemic and operational efficiencies as well as the technological competencies of Singapore companies, to locations where these attributes are less distinct. This paper, as part of our series on this topic, revisits the city-state’s determined efforts to encapsulate economic space for Singapore-based firms, enabling them to expand beyond the region. This paper however, focuses specifically on the gambits of Singapore’s government-linked companies (GLCs) in the Gulf region (GCC countries). Our research shows with purely commercial purposes as the priority, political objectives (and the attendant advantages and complications) tend to take a back seat; that, following from this, the ostensible strategic advantages present in Singapore-styled management and methodology remain uncertain; and that socio-political intricacies in new environments often stymie efforts to import competencies and business practices wholesale

Growth mechanism and interface magnetic properties of Co nanostructures on graphite

We investigated structural, electronic, and magnetic properties of Co adsorbed on highly oriented pyrolytic graphite (HOPG). Distribution and atomic sites of 3d transition-metal Co nanoislands and adatoms on HOPG were experimentally investigated by scanning tunneling microscopy with atomic resolution. In the very low thickness regime (0.6 A° ), a strong nucleation mechanism and a preferred Co nanoisland diameter of ∼3.4 nm have been observed. Co adatoms were found to preferentially occupy β sites of the HOPG surface graphene layer and the atoms aggregated by further occupation of either α or overbond sites. This is in contrast to predictions based on density functional theory, which indicates that the hollow sites are the most energetically stable sites for Co adsorption. The presence of surface hydrocarbon contamination on graphite might be one possible cause of the observed active nucleation and stabilized nanoisland diameter of Co. The formation of Co carbide was evidenced by x-ray absorption spectroscopy. More importantly, the Co magnetic spin moment at the interface of Fe-capped ferromagnetic Co nanostructures and graphite, as determined by x-ray magnetic circular dichroism and sum-rule analysis, was found to be only 63% of the bulk value, implying a magnetically defective spin contact for carbon spintronics applications

Using Latent Class Analyses to Examine Health Disparities among Young Children in Socially Disadvantaged Families during the COVID-19 Pandemic

Rising income inequality is strongly linked to health disparities, particularly in regions where uneven distribution of wealth and income has long been a concern. Despite emerging evidence of COVID-19-related health inequalities for adults, limited evidence is available for children and their parents. This study aimed to explore subtypes of families of preschoolers living in the disadvantaged neighborhoods of Hong Kong based on patterns of family hardship and to compare their patterns of parenting behavior, lifestyle practices, and wellbeing during the COVID-19 pandemic. Data were collected from 1338 preschoolers and their parents during March to June 2020. Latent class analysis was performed based on 11 socioeconomic and disease indicators. Multivariate logistic regressions were used to examine associations between identified classes and variables of interest during the COVID-19 pandemic. Four classes of family hardship were identified. Class 1 (45.7%) had the lowest disease and financial burden. Class 2 (14.0%) had the highest financial burden. Class 3 (5.9%) had the highest disease burden. Class 4 (34.5%) had low family income but did not receive government welfare assistance. Class 1 (low hardship) had lower risks of child maltreatment and adjustment problems than Class 2 (poverty) and Class 3 (poor health). However, children in Class 1 (low hardship) had higher odds of suffering psychological aggression and poorer physical wellbeing than those in Class 4 (low income), even after adjusting for child age and gender. The findings emphasize the need to adopt flexible intervention strategies in the time of large disease outbreak to address diverse problems and concerns among socially disadvantaged families

Evidence of individual differences in the long-term social, psychological, and cognitive consequences of child maltreatment

Background: The prevalence and consequences of child maltreatment are alarming, but evidence from studies with long follow-up intervals are limited. This study examined the long-term consequences of child maltreatment in relation to age of onset and follow-up interval. / Methods: The exposed group comprised 63 individuals (aged 13–34 years) with a first-time diagnosis of child maltreatment between 2001 and 2010, whereas the unexposed group comprised 63 individuals who were matched upon gender, age of onset, follow-up period, and poverty status at the index hospital admission but had no medical records of maltreatment in Hong Kong. The participants completed a set of questionnaires on executive functions and mental health and provided blood samples for measurement of IL-6 and IL-10 levels during a health assessment session. / Results: Compared with the unexposed group, the exposed group reported poorer maternal care during childhood (β = −4.64, p < 0.001) and had lower family support (β = −2.97, p = 0.010) and higher inflammatory responses (IL-6: β = 0.15, p = 0.001; IL-10: β = 0.11, p = 0.011) at follow-up. Additionally, the associations of childhood maltreatment exposure with family support and maternal care differed by age of onset and the length of time since exposure. / Conclusions: This matched cohort study highlights childhood maltreatment as a risk factor for systemic inflammation and an indicator of suboptimal social environment, both of which could persist over a long period of time