2,950 research outputs found
Incidence of leafhoppers inhabiting sweet cherry orchards in the Kootenay Valley of British Columbia
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Effect of two spray programs on leafhoppers in cherry orchards in the Kootenay Valley of British Columbia
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Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a dismal prognosis. However, while most patients die within the first year of diagnosis, very rarely, a few patients can survive for >10 years. Better understanding the molecular characteristics of the pancreatic adenocarcinomas from these very-long-term survivors (VLTS) may provide clues for personalized medicine and improve current pancreatic cancer treatment. To extend our previous investigation, we examined the proteomes of individual pancreas tumor tissues from a group of VLTS patients (survival ≥10 years) and short-term survival patients (STS, survival <14 months). With a given analytical sensitivity, the protein profile of each pancreatic tumor tissue was compared to reveal the proteome alterations that may be associated with pancreatic cancer survival. Pathway analysis of the differential proteins identified suggested that MYC, IGF1R and p53 were the top three upstream regulators for the STS-associated proteins, and VEGFA, APOE and TGFβ-1 were the top three upstream regulators for the VLTS-associated proteins. Immunohistochemistry analysis using an independent cohort of 145 PDAC confirmed that the higher abundance of ribosomal protein S8 (RPS8) and prolargin (PRELP) were correlated with STS and VLTS, respectively. Multivariate Cox analysis indicated that 'High-RPS8 and Low-PRELP' was significantly associated with shorter survival time (HR=2.69, 95% CI 1.46-4.92, P=0.001). In addition, galectin-1, a previously identified protein with its abundance aversely associated with pancreatic cancer survival, was further evaluated for its significance in cancer-associated fibroblasts. Knockdown of galectin-1 in pancreatic cancer-associated fibroblasts dramatically reduced cell migration and invasion. The results from our study suggested that PRELP, LGALS1 and RPS8 might be significant prognostic factors, and RPS8 and LGALS1 could be potential therapeutic targets to improve pancreatic cancer survival if further validated
From dispersionless to soliton systems via Weyl-Moyal like deformations
The formalism of quantization deformation is reviewed and the Weyl-Moyal like
deformation is applied to systematic construction of the field and lattice
integrable soliton systems from Poisson algebras of dispersionless systems.Comment: 26 page
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Efficient calculation of two-dimensional periodic and waveguide acoustic Green’s functions
New representations and efficient calculation methods are derived for the problem of propagation from an infinite regularly spaced array of coherent line sources above a homogeneous impedance plane, and for the Green's function for sound propagation in the canyon formed by two infinitely high, parallel rigid or sound soft walls and an impedance ground surface. The infinite sum of source contributions is replaced by a finite sum and the remainder is expressed as a Laplace-type integral. A pole subtraction technique is used to remove poles in the integrand which lie near the path of integration, obtaining a smooth integrand, more suitable for numerical integration, and a specific numerical integration method is proposed. Numerical experiments show highly accurate results across the frequency spectrum for a range of ground surface types. It is expected that the methods proposed will prove useful in boundary element modeling of noise propagation in canyon streets and in ducts, and for problems of scattering by periodic surfaces
The Phase Transition to a Square Vortex Lattice in Type-II Superconductors with Fourfold Anisotropy
We investigate the stability of the square vortex lattice which has been
recently observed in experiments on the borocarbide family of superconductors.
Taking into account the tetragonal symmetry of these systems, we add fourfold
symmetric fourth-derivative terms to the Ginzburg-Landau(GL) free energy. At
these terms may be treated perturbatively to lowest order to locate
the transition from a distorted hexagonal to a square vortex lattice. We also
solve for this phase boundary numerically in the strongly type-II limit,
finding large corrections to the lowest-order perturbative results. We
calculate the relative fourfold anisotropy for field in the plane
to be 4.5% at the temperature, , where the transition occurs at
for field along the axis. This is to be compared to the 3.6%
obtained in the perturbative calculation. Furthermore, we find that the phase
boundary in the phase diagram has positive slope near .Comment: 15 pages including 2 figures, LaTe
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