39 research outputs found
Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?
Purpose: There is ongoing concern regarding increased toxicity from paclitaxel in elderly patients, particularly of severe neutropenia. Yet, data so far is controversial and this concern is not supported by a clinically relevant age-dependent difference in pharmacokinetics (PK) of paclitaxel. This study assessed whether age is associated with increased risk for paclitaxel-induced neutropenia. Methods: Paclitaxel plasma concentration-time data, pooled from multiple different studies, was combined with available respective neutrophil count data during the first treatment cycle. Paclitaxel pharmacokinetic-pharmacodynamic (PK-PD) d
De wondere wereld van de streektaalgrenzen : lezingen gehouden op de internationale streektaalconferentie
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Impact of Older Age on the Exposure of Paclitaxel: a Population Pharmacokinetic Study
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