Adverse Childhood Experiences and Acute Coronary Syndrome in Adulthood

Research studies demonstrate that exposure to adverse childhood experiences (ACEs) lead to physical and mental health consequences in adulthood, including cardiovascular disease (Dong, Giles, Felitti et al, 2004; Felitti, Anda, Nordenberg, et al, 1998). One potential mechanism linking ACEs to cardiovascular disease is impaired social competence necessary for successful relationships and adequate social support. In the current study, the impact of ACEs on social support and subsequent incidence of acute coronary syndrome (ACS) was examined in a cohort of 6,596 older Seventh-day Adventists. After controlling for sociodemographic, lifestyle, and psychological factors, ACE exposure predicted increased risk of ACS by 31% for males only. Similarly, exposure to 3 or more ACEs resulted in a more than 3-fold increased risk of ACS for males compared to no ACEs. While ACE exposure had positive associations with negative social support and negative spouse/partner support, there were no associations with social integration. Social integration and support measures did not mediate the ACE-ACS relationship; even in supplementary analyses combining cardiac-related mortality and ACS. However, several gender and poverty moderation effects emerged. Church attendance decreased the risk of ACS in females in poverty, after controls and ACE exposure. Among females in poverty, negative social support and negative spouse support increased the risk of ACS incidence after controls and ACE exposure. Among males not in poverty, suppression effects were found, suggesting that having low negative support and negative spouse/partner support decreased the risk of ACS incidence as well as combined ACS and cardiac-mortality. Although non-significant, suppression patterns for poverty subgroups revealed that any increase in negative support or spouse/partner support, leads to increase in ACS incidence and combined ACS and cardiac mortality. Together, the findings highlight the long-term impact of ACEs on cardiac health, and the importance of considering non-traditional risk factors (such social support and church attendance), as critical pathways that can lead to cardiac health outcomes. Further examination of religiousness and emotion regulation pathways should follow to further elucidate on the mechanisms that underlie the ACE-ACS relationship

Forensic capabilities for service-oriented architectures

This report describes a framework to provide on-line forensic capabilities to service oriented architecture via Forensic Web Services (FWS) and runtime execution monitoring. The FWS is a new type of web services to be used by other web services (of an independent agency) to securely maintain transactional records of interest between other web services. The framework uses runtime execution monitoring to search the transactional log for interesting (or suspicious) service invocation sequences to recreate non-repudiable evidence of transactional history for use in a court of law.Contract Number: N6600107WR00222Approved for public release; distribution is unlimited

Large-Eddy Simulation of Flow over Two-Dimensional Obstacles: High Drag States and Mixing

A three-dimensional large-eddy simulation (LES) model was used to examine how stratified flow interacts with bottom obstacles in the coastal ocean. Bottom terrain representing a 2D ridge was modeled using a finite-volume approach with ridge height (4.5 m) and width (~30 m) and water depth (~45 m) appropriate for coastal regions. Temperature and salinity profiles representative of coastal conditions giving constant buoyancy frequency were applied with flow velocities between 0.16 and 0.4 m s⁻¹. Simulations using a free-slip lower boundary yielded flow responses ranging from transition flows with relatively high internal wave pressure drag to supercritical flow with relatively small internal wave drag. Cases with high wave drag exhibited strong lee-wave systems with wavelength of ~100 m and regions of turbulent overturning. Application of bottom drag caused a 5–10-m-thick bottom boundary layer to form, which greatly reduced the strength of lee-wave systems in the transition cases. A final simulation with bottom drag, but with a much larger obstacle height (16 m) and width (~400 m), produced a stronger lee-wave response, indicating that large obstacle flow is not influenced as much by bottom roughness. Flow characteristics for the larger obstacle were more similar to hydraulic flow, with lee waves that are relatively short in comparison with the obstacle width. The relatively strong effect of bottom roughness on the small obstacle wave drag suggests that small-scale bottom variations may be ignored in internal wave drag parameterizations. However, the more significant wave drag from larger-scale obstacles must still be considered and may be responsible for mixing and momentum transfer at distances far from the obstacle source

A cognitive approach to user perception of multimedia quality: An empirical investigation

Whilst multimedia technology has been one of the main contributing factors behind the Web's success, delivery of personalized multimedia content has been a desire seldom achieved in practice. Moreover, the perspective adopted is rarely viewed from a cognitive styles standpoint, notwithstanding the fact that they have significant effects on users’ preferences with respect to the presentation of multimedia content. Indeed, research has thus far neglected to examine the effect of cognitive styles on users’ subjective perceptions of multimedia quality. This paper aims to examine the relationships between users’ cognitive styles, the multimedia quality of service delivered by the underlying network, and users’ quality of perception (understood as both enjoyment and informational assimilation) associated with the viewed multimedia content. Results from the empirical study reported here show that all users, regardless of cognitive style, have higher levels of understanding of informational content in multimedia video clips (represented in our study by excerpts from television programmes) with weak dynamism, but that they enjoy moderately dynamic clips most. Additionally, multimedia content was found to significantly influence users’ levels of understanding and enjoyment. Surprisingly, our study highlighted the fact that Bimodal users prefer to draw on visual sources for informational purposes, and that the presence of text in multimedia clips has a detrimental effect on the knowledge acquisition of all three cognitive style groups

The growth of the oceanic boundary layer during the COARE intensive observational period: Large Eddy simulation results

A principal goal of the Tropical Ocean Global Atmosphere (TOGA) Coupled Ocean-Atmosphere Response Experiment (COARE) is to gain an understanding of the processes that control mixing in the upper 100 m of the western tropical Pacific warm pool. The warm pool is an important heat reservoir for the global ocean and is responsible for many of the observed climatic changes associated with El Nino/Southern Oscillation (ENSO) events. This water mass is highly sensitive to mixed-layer processes that are controlled by surface heat, salinity, and momentum fluxes. During most of the year, these fluxes are dominated by solar heating and occasional squalls that freshen the top of the mixed layer and force shallow mixing of about 10-20 m. From November to April, the usual weather pattern is frequently altered by westerly wind bursts that are forced by tropical cyclones and intraseasonal oscillations. These wind bursts generate a strong eastward surface current and can force mixing as deep as 100 m over a period of days. Observations from the intensive observation period (IOP) in COARE indicate that mixed-layer deepening is accompanied by strong turbulence dissipation at the mixed layer base. A short westerly wind burst occurred during the first leg of TOGA-COARE, and lasted about 4-5 days. During this period, the maximum winds were about 10 m s{sup -1}, and the resulting eastward surface flow was about 0.5 m s{sup -1}. The strength of this event was somewhat weaker than a typical westerly wind burst, but the mixed-layer structure and growth are similar to the more vigorous wind bursts discussed

Latent cluster analysis of ALS phenotypes identifies prognostically differing groups

BACKGROUND Amyotrophic lateral sclerosis (ALS) is a degenerative disease predominantly affecting motor neurons and manifesting as several different phenotypes. Whether these phenotypes correspond to different underlying disease processes is unknown. We used latent cluster analysis to identify groupings of clinical variables in an objective and unbiased way to improve phenotyping for clinical and research purposes. METHODS Latent class cluster analysis was applied to a large database consisting of 1467 records of people with ALS, using discrete variables which can be readily determined at the first clinic appointment. The model was tested for clinical relevance by survival analysis of the phenotypic groupings using the Kaplan-Meier method. RESULTS The best model generated five distinct phenotypic classes that strongly predicted survival (p<0.0001). Eight variables were used for the latent class analysis, but a good estimate of the classification could be obtained using just two variables: site of first symptoms (bulbar or limb) and time from symptom onset to diagnosis (p<0.00001). CONCLUSION The five phenotypic classes identified using latent cluster analysis can predict prognosis. They could be used to stratify patients recruited into clinical trials and generating more homogeneous disease groups for genetic, proteomic and risk factor research

Eco-geographic survey of wild species of Vigna in Sri Lanka

The ceo-geographic survey of plant genetic resources is essential for effective in situ and ex situconservation of plant genetic resources. Results of eco-geographic survey could be used to predictnew areas for survey and to assist in the formulation of collection and conservation priorities. An ecogeographicsurvey was conducted in Sri Lanka during August 2005 to February 2006 in some protectedareas and other target areas of Sri Lanka to locate wild species of Vigna, map their localities, identifythreatened areas and find out suitable locations for in-situ conservation.Habitats and taxonomic characteristics data were recorded. Locations of wild spices of Vigna werenoted by using Global Positioning System (GPS). The distribution of six wild species of Vigna occurringin Sri Lanka is depicted in the maps. GPS data were analyzed by Flora map distribution modelling andprobable localities of Vigna wild species were mapped. Six species of Vigna recorded by the surveyare distributed from 0 MSL to 1630 m MSL. However, V stipulacea, V trilobata and V aridicolawere found only lower latitudes (0 to 130 m MSL) and V dalzilliana and V trinervia are limited tohigher elevation (790m to 1630m MSL). Vigna radiata var. sublobata was found only in one locationDambana in Badulla district. V stipulacea, and V trilobata are mostly found near sea shore and Varidicola is found in inland dry areas. Difference in leaf shape of V trilobata is observed in differentpopulations. The probable areas that were identified using flora map modelling are located in Puttalam,Polonnaruwa, Ampara, Kurunagala and Batticola districts. Surveys in these areas are needed toidentify new populations ofwild Vigna species.

A novel therapeutic effect of mannitol-rich extract from the brown seaweed Sargassum ilicifolium using in vitro and in vivo models

Background: Wound healing is an active, complex, integrated series of cellular, physiological, and biochemical changes initiated by the stimulus of injury in a tissue. The present study was performed to investigate the potential wound healing abilities of Sargassum ilicifolium crude extracts (CE) that were characterized by 1H NMR and FTIR Spectrometric measurements. Materials and methods: Seaweed samples were collected from southern coastal sites of Sri Lanka. To determine the cytotoxicity and proliferation of S. ilicifolium CE were used for the MTT and alamarBlue assays respectively. The scratch and exclusion wound models were used to HaCaT and HDF cells to assess the cell proliferation and migration. RAW 264.7 cells (macrophages) were used to evaluate Nitric Oxide (NO) production and phagocytosis activities. Moreover, Fifteen, 8-week-old, female, New Zealand rabbits were selected and divided into five groups: excision skin wounds (10.40 ± 0.60 mm) were induced in groups I, II, and III. Rabbits in groups I and IV were given S. ilicifolium CE (orally, 100 mg/kg day, two weeks), whereas groups II and V were given equal amounts of distilled water. Wound healing properties were measured and wound tissue samples were collated, formalin-fixed, wax-embedded, stained (Hematoxylin and Eosin; Van Gieson) and examined for the healing process. Results: Anti-inflammatory and wound healing activities were observed in RAW 264.7, HDF and HaCaT cells treated with S. ilicifolium aqueous extracts when compared to the control groups. S. ilicifolium extracts concentration 8 - 4 μg/μL, (P<0.05) had remarkable the highest proliferative and migratory effects on RAW 264.7, HDF and HaCaT cells when compared with the control. RAW 264.7 cell proliferation and/or migration were higher in S. ilicifolium extracts (4 μg/μL, 232.8 ± 10.07%) compared with the control (100 %). Scratch wound healing were remarkably enhanced in 24 h, 48 h (P<0.05) when treated with S. ilicifolium on HaCaT cells. Rabbits treated with the CE of S. ilicifolium showed a significantly increased wound healing activities (P<0.05) within three days with a close wound area of 57.21 ± 0.77 % compared with control group (26.63 ± 1.09 %). Histopathology, aspartate aminotransferase and alanine aminotransferase levels evidenced no toxic effects on seaweed treated groups. Histopathological results also revealed that the healing process was significantly faster in the rabbit groups which were as treated with CE of S. ilicifolium orally with the evidence of enhanced early granulation tissue (connective tissue and angiogenesis) and significant epithelization compared to the control. Conclusions: Cell proliferation and migration are significantly faster when treated with S. ilicifolium aqueous extracts. Moreover, there are no toxic effect of S. ilicifolium aqueous extracts on RAW 264.7, HDF and HaCaT cell lines. In this study, it is revealed that S. ilicifolium has potential remedial agent; D-Mannitol for skin wound healing properties that by promote keratinocyte and fibroblast proliferation and migration. These findings show that S. ilicifolium have promising wound healing properties

Mixing to monsoons: Air-sea interactions in the bay of Bengal

More than 1 billion people depend on rainfall from the South Asian monsoon for their livelihoods. Summertime monsoonal precipitation is highly variable on intraseasonal time scales, with alternating "active" and "break" periods. These intraseasonal oscillations in large-scale atmospheric convection and winds are closely tied to 1°C-2°C variations of sea surface temperature in the Bay of Bengal