Effect of polymer properties and adherend surfaces on adhesion

The surface properties associated with good adhesive joints were evaluated in terms of application of adhesive bonding in aerospace technology. The physical and chemical nature was determined of Ti and Al adherend surfaces after various surface treatments, and the effects on fracture surfaces of high temperature aging, and variations in amide, anhydride, and solvent during polymer synthesis. The effects were characterized of (1) high temperature during shear strength testing, (2) fiber-reinforced composites as adherends, (3) acid/base nature of adherends, (4) aluminum powder adhesive filler, and (5) bonding pressure

Reactivation of the mitosis-promoting factor in postmitotic cardiomyocytes

Cardiomyocytes cease to divide shortly after birth and an irreversible cell cycle arrest is evident accompanied by the downregulation of cyclin-dependent kinase activities. To get a better understanding of the cardiac cell cycle and its regulation, the effect of functional recovery of the mitosis-promoting factor (MPF) consisting of cyclin B1 and the cyclin-dependent kinase Cdc2 was assessed in primary cultures of postmitotic ventricular adult rat cardiomyocytes ( ARC). Gene transfer into ARC was achieved using the adenovirus-enhanced transferrinfection system that was characterized by the absence of cytotoxic events. Simultaneous ectopic expression of wild-type versions of cyclin B1 and Cdc2 was sufficient to induce MPF activity. Reestablished MPF resulted in a mitotic phenotype, marked by an abnormal condensation of the nuclei, histone H3 phosphorylation and variable degree of decay of the contractile apparatus. Although a complete cell division was not observed, the results provided conclusive evidence that cell cycle-related events in postmitotic cardiomyocytes could be triggered by genetic intervention downstream of the G1/S checkpoint. This will be of importance to design novel strategies to overcome the proliferation arrest in adult cardiomyocytes

Infinite Infrared Regularization and a State Space for the Heisenberg Algebra

We present a method for the construction of a Krein space completion for spaces of test functions, equipped with an indefinite inner product induced by a kernel which is more singular than a distribution of finite order. This generalizes a regularization method for infrared singularities in quantum field theory, introduced by G. Morchio and F. Strocchi, to the case of singularites of infinite order. We give conditions for the possibility of this procedure in terms of local differential operators and the Gelfand- Shilov test function spaces, as well as an abstract sufficient condition. As a model case we construct a maximally positive definite state space for the Heisenberg algebra in the presence of an infinite infrared singularity.Comment: 18 pages, typos corrected, journal-ref added, reference adde

Contrasting Regulation of Catecholamine Neurotransmission in the Behaving Brain: Pharmacological Insights from an Electrochemical Perspective

Catecholamine neurotransmission plays a key role in regulating a variety of behavioral and physiologic processes, and its dysregulation is implicated in both neurodegenerative and neuropsychiatric disorders. Over the last four decades, in vivo electrochemistry has enabled the discovery of contrasting catecholamine regulation in the brain. These rapid and spatially resolved measurements have been conducted in brain slices, and in anesthetized and freely behaving animals. In this review, we describe the methods enabling in vivo measurements of dopamine and norepinephrine, and subsequent findings regarding their release and regulation in intact animals. We thereafter discuss key studies in awake animals, demonstrating that these catecholamines are not only differentially regulated, but are released in opposition of each other during appetitive and aversive stimuli

A fundamental approach to the sticking of insect residues to aircraft wings

A proposed testing scheme is described for obtaining data on the effects of surface roughness and surface energy on insect adhesion. The road test apparatus is discussed as well as surface preparation techniques. Uncoated and polymer coated metal substrates were analyzed by SEM/ESCA/IRS before and following collision with insects. Critical surface tensions of unexposed Nyebar and poly sulfone coatings were 10 and 33 dynes/cm, respectively, as determined from contact angles. A total of 95% of insect residues collected belong to order Diptera. Significantly less insect debris was detected on the coated plates as compared to the uncoated plates. Minimal contamination at the 5 nm level of both coated and uncoated plates occurs even after hours of exposure to road conditions as determined by ESCA analysis. The presence of nitrogen detected by ESCA on exposed plates is unequivocal evidence for insect residues left on plates

Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal

Dysregulated catecholamine signaling has long been implicated in drug abuse. Although much is known about adaptations following chronic drug administration, little work has investigated how a single drug exposure paired with withdrawal influences catecholamine signaling in vivo. We used fast-scan cyclic voltammetry in freely moving rats to measure real-time catecholamine overflow during acute morphine exposure and naloxone-precipitated withdrawal in two regions associated with the addiction cycle: the dopamine-dense nucleus accumbens (NAc) and norepinephrine-rich ventral bed nucleus of the stria terminalis (vBNST). We compared dopamine transients in the NAc with norepinephrine concentration changes in the vBNST, and correlated release with specific withdrawal-related behaviors. Morphine increased dopamine transients in the NAc, but did not elicit norepinephrine responses in the vBNST. Conversely, dopamine output was decreased during withdrawal, while norepinephrine was released in the vBNST during specific withdrawal symptoms. Both norepinephrine and withdrawal symptoms could be elicited in the absence of morphine by administering naloxone with an α2 antagonist. The data support reciprocal roles for dopamine and norepinephrine signaling during drug exposure and withdrawal. The data also support the allostasis model and show that negative-reinforcement may begin working after a single exposure/withdrawal episode

An investigation of adhesive/adherend and fiber/matrix interactions. Part B: SEM/ESCA analysis of fracture surfaces

Adhesion was studied with emphasis on the characterization of surface oxide layers, the analysis of fracture surfaces, and the interaction of matrices and fibers. A number of surface features of the fractured lap shear samples were noted in the SEM photomicrographs including the beta phase alloy of the Ti 6-4 adherend, the imprint of the adherend on the adhesive failure surface, increased void density for high temperature samples, and the alumina filler particles. Interfacial failure of some of the fractured lap shear samples is invariably characterized by the appearance of an ESCA oxygen photopeak at 530.3 eV assigned to the surface oxide layer of Ti 6-4 adherend. The effect of grit blasting on carbon fiber composites is evident in the SEM analysis. A high surface fluorine concentration on the composite surface is reduced some ten fold by grit blasting

The structure of the quantum mechanical state space and induced superselection rules

The role of superselection rules for the derivation of classical probability within quantum mechanics is investigated and examples of superselection rules induced by the environment are discussed.Comment: 11 pages, Standard Latex 2.0

Interacting Vector-Spinor and Nilpotent Supersymmetry

We formulate an interacting theory of a vector-spinor field that gauges anticommuting spinor charges \{Q_\alpha{}^I, Q_\beta{}^J \} = 0 in arbitrary space-time dimensions. The field content of the system is (\psi_\mu{}^{\alpha I}, \chi^{\alpha I J}, A_\mu{}^I), where \psi_\mu{}^{\alpha I} is a vector-spinor in the adjoint representation of an arbitrary gauge group, and A_\mu{}^I is its gauge field, while \chi^{\alpha I J} is an extra spinor with antisymmetric adjoint indices I J. Amazingly, the consistency of the vector-spinor field equation is maintained, despite its non-trivial interactions.Comment: 10 pages, no figure

Desarrollo de máquinas-herramienta y sistemas de manufactura asistidos por computador

Aborda tres tópicos fundamentales: el uso de computadores en el proceso manufacturero; los criterios para pasar de la manufactura y uso de máquinas herramientas manuales, al uso de máquinas controladas numéricamente por computador; una revisión a los requerimientos para implementar un programa de modernización.It addresses three fundamental topics: the use of computers in the manufacturing process; the criteria for moving from the manufacture and use of manual machine tools to the use of numerically controlled machines by computer; a review of the requirements to implement a modernization program.Definiciones -- Sistemas de control de máquinas -- Sistemas de programación -- CAD/CAM -- Características del control numérico vs. máquinas manuales -- Automatización de máquinas tradicionales -- El papel de los computadores en la manufactura -- Diseño de manufactura de máquinas-herramienta NC -- Criterios de actualización.naRetoma los aspectos más relevantes del documento con el mismo título presentado por el autor durante el seminario organizado por SENA, FEDEMETAL y COLCIENCIAS,en abril de 1988: "Situación Actual de la incorporación de nuevas tecnologías en la industria metalúrgica y de bienes de capital".36 página