Control room operators’ cue utilization predicts cognitive resource consumption during regular operational tasks

This study was designed to examine whether qualified practitioners' cue utilization is predictive of their sustained attention performance during regular operational tasks. Simulated laboratory studies have demonstrated that cue utilization differentiates cognitive load during process control tasks. However, it was previously unclear whether similar results would be demonstrated with qualified practitioners during familiar operational tasks. Australian distribution network service provider (DNSP) operators were classified with either higher or lower cue utilization based on an assessment of cue utilization within the context of electrical power distribution. During two, 20-min periods of operators' regular workdays, physiological measures of workload were assessed through changes in cerebral oxygenation in the prefrontal cortex compared to baseline, and through eye behavior metrics (fixation rates, saccade amplitude, and fixation dispersion). The results indicated that there were no statistically significant differences in eye behavior metrics, based on levels of cue utilization. However, as hypothesized, during both sessions, operators with higher cue utilization demonstrated smaller increases in cerebral oxygenation in the prefrontal cortex from baseline, compared to operators with lower cue utilization. The results are consistent with the proposition that operators with higher cue utilization experience lower cognitive load during periods of regular activity during their workday, compared to operators with lower cue utilization. Assessments of cue utilization could help identify operators who are better able to sustain attention during regular operational tasks, as well as those who may benefit from cue-based training interventions.Daniel Sturman, Mark W. Wiggins, Jaime C. Auton, Shayne Loft, William S. Helton, Johanna I. Westbrook and Jeffrey Braithwait

PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data from 9 Studies of Blacks and Whites

PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident coronary heart disease and stroke through a meta-analysis of data from 8 observational cohorts and 1 randomized trial of statin therapy. Methods and Results - These 9 studies together included 17 459 blacks with 403 (2.3%) having at least 1 Y142X or C679X variant and 31 306 whites with 955 (3.1%) having at least 1 R46L variant. Unadjusted odds ratios for associations between PCSK9 LOF variants and incident coronary heart disease (851 events in blacks and 2662 events in whites) and stroke (523 events in blacks and 1660 events in whites) were calculated using pooled Mantel-Haenszel estimates with continuity correction factors. Pooling results across studies using fixed-effects inverse-variance-weighted models, PCSK9 LOF variants were associated with 35 mg/dL (95% confidence interval [CI], 32-39) lower LDL-C in blacks and 13 mg/dL (95% CI, 11-16) lower LDL-C in whites. PCSK9 LOF variants were associated with a pooled odds ratio for coronary heart disease of 0.51 (95% CI, 0.28-0.92) in blacks and 0.82 (95% CI, 0.63-1.06) in whites. PCSK9 LOF variants were not associated with incident stroke (odds ratio, 0.84; 95% CI, 0.48-1.47 in blacks and odds ratio, 1.06; 95% CI, 0.80-1.41 in whites). Conclusions - PCSK9 LOF variants were associated with lower LDL-C and coronary heart disease incidence. PCSK9 LOF variants were not associated with stroke risk

Serum magnesium and calcium levels in relation to ischemic stroke : Mendelian randomization study

ObjectiveTo determine whether serum magnesium and calcium concentrations are causally associated with ischemic stroke or any of its subtypes using the mendelian randomization approach.MethodsAnalyses were conducted using summary statistics data for 13 single-nucleotide polymorphisms robustly associated with serum magnesium (n = 6) or serum calcium (n = 7) concentrations. The corresponding data for ischemic stroke were obtained from the MEGASTROKE consortium (34,217 cases and 404,630 noncases).ResultsIn standard mendelian randomization analysis, the odds ratios for each 0.1 mmol/L (about 1 SD) increase in genetically predicted serum magnesium concentrations were 0.78 (95% confidence interval [CI] 0.69-0.89; p = 1.3 7 10-4) for all ischemic stroke, 0.63 (95% CI 0.50-0.80; p = 1.6 7 10-4) for cardioembolic stroke, and 0.60 (95% CI 0.44-0.82; p = 0.001) for large artery stroke; there was no association with small vessel stroke (odds ratio 0.90, 95% CI 0.67-1.20; p = 0.46). Only the association with cardioembolic stroke was robust in sensitivity analyses. There was no association of genetically predicted serum calcium concentrations with all ischemic stroke (per 0.5 mg/dL [about 1 SD] increase in serum calcium: odds ratio 1.03, 95% CI 0.88-1.21) or with any subtype.ConclusionsThis study found that genetically higher serum magnesium concentrations are associated with a reduced risk of cardioembolic stroke but found no significant association of genetically higher serum calcium concentrations with any ischemic stroke subtype

The development and validation of a short-duration sustained visual search task for process control environments

This study was designed to validate a short-duration sustained visual search task for the assessment of sustained attention in process control environments. The task consists of 10 short dynamic scenarios, which require participants (N = 121) to monitor simulated operating power transmission interfaces, and identify system faults. A vigilance decrement was demonstrated throughout the sustained visual search task, as evident in increased response latencies and decreased accuracy over time. Further, changes in response latency throughout the sustained visual search task were positively associated with changes in response latency during a 30-min, low signal probability task, a 45-min low signal probability task, and a 45-min high signal probability task. The findings indicate that the sustained visual search task may be a valid alternative to a longer-duration process control task for experimental studies, and is likely to be of value for assessments of the capacity for sustained attention of operators in process control environments.Daniel Sturman, Mark W.Wiggins, William S.Helton, Jaime C.Auto