1,030 research outputs found

    Deconstruction and the Question of Palestine: bearing witness to the undeniable

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    While deconstruction has been taken up widely in the field of Postcolonial Studies, there is very little work done on the relationship between deconstruction and the question of Palestine. This thesis maintains that deconstruction has both something to offer the discourses surrounding the question of Palestine and that deconstruction needs to be opened up to the undeniable if it is to continue to be relevant to contemporary emancipation struggles, specifically here the Palestinian struggle. This is not to say that the Palestinian struggle needs deconstruction, or that deconstruction can provide some magical solution. The aim of this thesis is rather to explore Derrida’s own attitudes towards Israel/Palestine and to ask whether deconstruction is hospitable to the needs of Palestinian self-determination

    Systematic review of antimicrobial drug prescribing in hospitals.

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    Prudent antibiotic prescribing to hospital inpatients has the potential to reduce the incidences of antimicrobial resistance and healthcare-associated infection. We reviewed the literature from January 1980 to November 2003 to identify rigorous evaluations of interventions to improve hospital antibiotic prescribing. We identified 66 studies with interpretable data of which 16 reported 20 microbiological outcomes: Gram negative resistant bacteria (GNRB), 10 studies; Clostridium difficile associated diarrhoea (CDAD), 5 studies; vancomycin resistant enterococci (VRE), 3 studies and methicillin resistant Staphylococcus aureus (MRSA), 2 studies. Four studies provide good evidence that the intervention changed microbial outcomes with low risk of alternative explanations, eight studies provide less convincing evidence and four studies were negative. The strongest and most consistent evidence was for CDAD but we were able to analyse only the immediate impact of interventions because of nonstandardised durations of follow up. The ability to compare results of studies could be substantially improved by standardising methodology and reporting

    An algorithm was developed to assign GRADE levels of evidence to comparisons within systematic reviews

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    Objectives: One recommended use of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach is supporting quality assessment of evidence of comparisons included within a Cochrane overview of reviews. Within our overview, reviewers found that current GRADE guidance was insufficient to make reliable and consistent judgments. To support our ratings, we developed an algorithm to grade quality of evidence using concrete rules. Methods: Using a pragmatic, exploratory approach, we explored the challenges of applying GRADE levels of evidence and developed an algorithm to applying GRADE levels of evidence in a consistent and transparent approach. Our methods involved application of algorithms and formulas to samples of reviews, expert panel discussion, and iterative refinement and revision. Results: The developed algorithm incorporated four key criteria: number of participants, risk of bias of trials, heterogeneity, and methodological quality of the review. A formula for applying GRADE level of evidence from the number of downgrades assigned by the algorithm was agreed. Conclusion: Our algorithm which assigns GRADE levels of evidence using a set of concrete rules was successfully applied within our Cochrane overview. We propose that this methodological approach has implications for assessment of quality of evidence within future evidence syntheses

    Online CBT for individuals with Christian beliefs: a pilot randomised controlled trial ; and Clinical Research Portfolio

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    Objectives: To investigate proof of concept, feasibility and efficacy of an online Cognitive Behavioural Therapy (CBT) intervention, modified to appeal to Christians who may be reluctant to access secular mental health services. Methods: 52 volunteers with Christian beliefs experiencing low mood or anxiety were recruited (median age=46.5, 25% male) to a pilot randomised waiting-list controlled trial of an online Spiritually-integrated CBT resource, with assessments at baseline, 8 weeks and 12 weeks. Primary outcome measures addressed mood, anxiety and general functioning. Results: No significant differences were found between groups on improvement of primary outcome measures, however there were non-significant trends in favour of those who had access to the course compared with waiting list control on all primary outcome measures. Conclusion: Online CBT targeted at religious groups may be an effective and practical means of promoting evidence-based psychological interventions to individuals who may not otherwise access them
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