Renforcer la prévention des maladies et la promotion de la santé dans l'entreprise: évaluation des besoins et de l'intérêt des collaborateurs pour le renforcement de la politique sanitaire développée par l'entreprise Nestlé sur son site de Vevey-Bergère

L'IUMSP a été chargé de mesurer l'état de santé subjectif et les modes de vie des employées de l'entreprise Nestlé, d'estimer la fréquence à laquelle ils sont exposés à certains facteurs de risque dans le contexte de leur activité professionnelle et de leur vie privée, de mettre en évidence l'existence de facteurs protecteurs, d'évaluer leurs pratiques en matière de consultation médicale et de déterminer leur volonté de participer à des actions de prévention. Notamment comparées aux informations fournies par l'Enquête suisse sur la santé, les données rassemblées pourront servir à construire des actions de prévention des maladies chroniques et dégénératives ou de promotion de la santé. Un questionnaire "Etat de santé, modes de vie" figure en annexe de ce document (en français & anglais). [Table des matières] 1. Méthodes. 1.1. Faisabilité de l'étude et élaboration du questionnaire. 1.2. Récolte des données. 1.3. Comparaison avec la population suisse. 2. Résultats : population, état de santé, état de santé subjectif, bien-être psychique, plaintes, malaises plus ou moins diffus (maux de tête, de dos, problèmes intestinaux), sommeil, état de santé "objectif", taille, poids, indice de masse corporelle, troubles visuels, troubles auditifs, cholestérol, hypertension, consommation de médicaments, maladies diagnostiquées et traitées, maladies et accidents professionnels, suivi médical et prévention, prise en charge par un médecin traitant - date et motif de la dernière consultation, prise en charge par un gynécologue - date de la dernière consultation, examens de dépistage, modes de vie, exercice physique, alimentation, alcool, tabac, produits stupéfiants, comportement sexuel, environnement professionnel, satisfaction au travail, motifs d'insatisfaction, nuisances perçues, impact des déplacements professionnels, pression (stress), prévention, dépistage et éducation à la santé dans le contexte de l'entreprise. 3. Recommandations. 4. Questionnaire. 5. Construction de l'indice de bien-être psychique

Tobacco use and attitudes towards a smoke-free policy : survey in the World Health Organization in Geneva

La consommation de tabac est la première cause de mortalité dans les pays occidentaux. Plusieurs études scientifiques ont également montré l'impact du tabagisme passif sur la santé. L'Organisation mondiale de la santé (OMS) a récemment identifié le contrôle du tabagisme (actif et passif) comme l'une de ses priorités pour les prochaines décennies. Ce contrôle peut être réalisé dans le cadre d'environnements professionnels sans fumée et de l'aide aux fumeurs souhaitant arrêter de fumer. Le lieu de travail devrait donc être aménagé afin de protéger les non-fumeurs de la fumée d'autrui. Une telle stratégie permet de réduire la consommation de cigarettes et fait progresser les fumeurs dans leur désaccoutumance au tabac. En 1999, le groupe "Tobacco free initiative" de l'OMS a mandaté l'Unité de prévention, (unité commune à l'Institut universitaire de médecine sociale et préventive et à la Policlinique médicale universitaire de Lausanne) de réaliser une enquête chez les employés de l'OMS. Les objectifs de cette enquête étaient les suivants : décrire la perception des employés et leurs connaissances en termes de contrôle du tabagisme ; déterminer leur exposition au tabagisme passif; connaître leur attitude envers une organisation totalement "smoke free" ; évaluer l'intérêt des fumeurs à bénéficier d'une aide à la désaccoutumance dans le cadre de leur activité professionnelle. [P. 4]]]> Health Policy ; Health Promotion ; Smoking ; Tobacco Smoke Pollution ; World Health Organization eng https://serval.unil.ch/resource/serval:BIB_D5D9E0FEA957.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D5D9E0FEA9577 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D5D9E0FEA9577 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_D5D9FE1D5924 2022-05-07T01:27:53Z openaire documents <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_D5D9FE1D5924 Firewalls Prevent Systemic Dissemination of Vectors Derived from Human Adenovirus Type 5 and Suppress Production of Transgene-Encoded Antigen in a Murine Model of Oral Vaccination. info:doi:10.3389/fcimb.2018.00006 info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2018.00006 info:eu-repo/semantics/altIdentifier/pmid/29423380 Revaud, J. Unterfinger, Y. Rol, N. Suleman, M. Shaw, J. Galea, S. Gavard, F. Lacour, S.A. Coulpier, M. Versillé, N. Havenga, M. Klonjkowski, B. Zanella, G. Biacchesi, S. Cordonnier, N. Corthésy, B. Ben Arous, J. Richardson, J.P. info:eu-repo/semantics/article article 2018 Frontiers in cellular and infection microbiology, vol. 8, pp. 6 info:eu-repo/semantics/altIdentifier/eissn/2235-2988 urn:issn:2235-2988 <![CDATA[To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastric administration of vectors encoding firefly luciferase or a model antigen, detectable levels of transgene-encoded protein or mRNA were confined to the intestine, and restricted to delimited anatomical zones. Expression of luciferase in the form of multiple small bioluminescent foci in the distal ileum, cecum, and proximal colon suggested multiple crossing points. Many foci were unassociated with visible Peyer's patches, implying that transduced cells lay in proximity to villous rather than follicle-associated epithelium, as supported by detection of transgene-encoded antigen in villous epithelial cells. Transgene-encoded mRNA but not protein was readily detected in Peyer's patches, suggesting that post-transcriptional regulation of viral gene expression might limit expression of transgene-encoded antigen in this tissue. To characterize the pathways by which the vector crossed the intestinal epithelium and encountered sentinel cells, a fluorescent-labeled vector was administered to mice by the intragastric route or inoculated into ligated intestinal loops comprising a Peyer's patch. The vector adhered selectively to microfold cells in the follicle-associated epithelium, and, after translocation to the subepithelial dome region, was captured by phagocytes that expressed CD11c and lysozyme. In conclusion, although a large number of crossing events took place throughout the intestine within and without Peyer's patches, multiple firewalls prevented systemic dissemination of vector and suppressed production of transgene-encoded protein in Peyer's patches

The effect of non-medical factors on variations in the performance of colonoscopy among different health care settings

Background: Previous studies in the literature have shown significant variations in colonoscopy performance, even when medical factors are taken into account. This study aimed to examine the role of non-medical factors (i.e. embodied in health care system design) as possible contributors to variations in colonoscopy performance. Methods: We used patient data from a multicenter observational study conducted between 2000 and 2002 in 21 centers across 11 western countries. Variability was captured through two performance outcomes (diagnostic yield and colonoscopy withdrawal time), jointly studied as dependent variables using a multilevel two-equation system. Results: Results showed that open-access systems and high-volume colonoscopy centers were independently associated with a higher likelihood of detecting significant lesions and higher withdrawal durations. Fee for service (FFS) payment was associated with shorter withdrawal durations, and had an indirect negative impact on the diagnostic yield. Teaching centers exhibited lower detection rates and higher withdrawal times. Conclusions: Our results suggest that gate-keeping colonoscopy is likely to miss patients with significant lesions and that developing specialized colonoscopy units is important to improve performance. Results also suggest that FFS may result in a lower quality of care in colonoscopy practice and highlight that longer withdrawal times do not necessarily mean higher quality in teaching-centers.Medical Practice Variation (MPV), performance, non-medical factors, panel two-equation linear-probit model, colonoscopy

Comparison of Serum Lipoprotein(a) Distribution and its Correlates among Black and White Populations

Bovet P (Clinical Epidemiology Unit, Institute of Social and Preventive Medicine, University of Lausanne, Bugnon 17, CH-1005 Lausanne, Switzerland), Rickenbach M, Wietlisbach V, Riesen W, Shamlaye C, Darioli R and Burnand B. Comparison of lipoprotein(a) distribution and its correlates among black and white populations. International Journal of Epidemiology 1994; 23: 20-27. Background Epidemiological data on serum lipoprotein(a) (Lp(a)), a presumably strong risk factor for coronary artery disease in White populations, has mostly been derived, in Black populations, from small samples. This study compares the distribution and the determinants of serum Lp(a) in Blacks and in Whites using large representative samples and the same methods in both populations. Methods The distribution and the correlates of serum Lp(a) were investigated in population-based samples of 701 Blacks in the Seychelles and 634 Whites in Switzerland, aged 25-64 years. Serum Lp(a) was quantified using a commercial immunoradiometric assay. Results The distribution of serum Lp(a) was similarly skewed in both ethnic groups, but median Lp(a) concentration was about two fold higher in Blacks (210 mg/l) compared to Whites (100 mg/l). The proportions of individuals with elevated serum Lp(a) >300 mg/l) was about 50% higher in Blacks (37.5%) than in Whites (25.2%). In both ethnic groups, serum Lp(a) was found to correlate with total cholesterol, LDL-cholesterol and apoprotein B but not with HDL-cholesterol, alcohol intake, smoking, and body mass index. The variance in serum Lp(a) concentration explained by any combination of these factors was smaller than 5.3% in the two populations. Conclusions The measured factors did not explain the higher levels of serum Lp(a) found in Blacks compared to Whites. These findings are consistent with the hypothesis that genetic factors account for much of the variation of serum Lp(a) in both population

Gastroenterologists overestimate the appropriateness of colonoscopies they perform: an international observational study

BACKGROUND AND STUDY AIM: Little is known about how gastroenterologists perceive the appropriateness of colonoscopies they perform. The objective of this study was to compare the appropriateness and necessity of colonoscopies as assessed by an expert panel and by the gastroenterologists performing the colonoscopies. METHODS: This observational study included 21 centers in 11 countries. Patients referred for colonoscopy were consecutively included. Appropriateness and necessity of colonoscopies were independently rated on a 9-point scale by the gastroenterologists performing them and by an expert panel using a validated method (RAND). The differences between the ratings from the two groups were examined. Results: 6004 patients were included in the study. Comparisons of ratings were possible for 5381 (89.6 %) patients. The gastroenterologists' mean appropriateness rating was 7.2 +/- 1.7, and the panel's mean appropriateness rating was 5.4 +/- 2.3 ( P &lt; 0.001). The percentages of indications rated inappropriate, uncertain, appropriate, and necessary were 4.1 %, 23.8 %, 14.2 %, and 58.0 % for the gastroenterologists and 27.2 %, 26.7 %, 25.0 %, and 21.1 % for the panel, respectively. Agreement between the two groups' ratings was poor (28.8 %, kappa = 0.11). Differences between the two groups' ratings decreased with increasing patient age, decreasing health status, and decreasing expertise level of the referring physician. However, the gastroenterologists produced consistently higher ratings. CONCLUSIONS: Compared with an expert panel, gastroenterologists tend to overestimate the appropriateness of colonoscopies they perform. Except for well-delineated reasons, participating gastroenterologists weighed patient characteristics differently from the panel when judging appropriateness. Ways to increase the prospective use of appropriateness criteria in order to improve appropriateness and reduce overuse of colonoscopies should be examined further. [Authors]]]> Colonoscopy ; Gastroenterology oai:serval.unil.ch:BIB_6852 2022-05-07T01:19:36Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_6852 Prospective randomized comparison of imipenem-cilastatin and piperacillin-tazobactam in nosocomial pneumonia or peritonitis. Jaccard, C Troillet, N Harbarth, S Zanetti, G Aymon, D Schneider, R Chioléro, R Ricou, B Romand, J Huber, O Ambrosetti, P Praz, G Lew, D Bille, J Glauser, MP Cometta, A info:eu-repo/semantics/article article 1998 Antimicrob Agents Chemother, vol. 42, pp. 2966-72 oai:serval.unil.ch:BIB_6852615BE8BB 2022-05-07T01:19:36Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_6852615BE8BB Smoked cannabis and doping control: looking for the wrong target analyte? Brenneisen, R. Meyer, P. Chtioui, H. Saugy, M. Schweizer, C. Kamber, M. info:eu-repo/semantics/conferenceObject inproceedings 2009-08 Annales de toxicologie analytique, vol. 21, pp. S25 Goullé, Jean-Pierre (ed.) info:eu-repo/semantics/altIdentifier/isbn/0768-598X <![CDATA[Introduction: Since 2004, cannabis is prohibited by the World Anti-Doping Agency (WADA) for all sports in competition. In the years since then, about half of all positive doping cases in Switzerland have been related to cannabis consumption. In most cases, the athletes plausibly claim to have consumed cannabis several days or even weeks before competition and only for recreational purposes not related to competition. In doping analysis, the target analyte in urine samples is 11-nor-delta-9-tetrahydrocannabinol- 9-carboxylic acid (THC-COOH), the reporting threshold for laboratories is 15 ng/mL. However, the wide detection window of this long-term THC metabolite in urine does not allow a conclusion concerning the time of consumption or the impact on the physical performance. Aim: The purpose of the present pharmacokinetic study on volunteers was to evaluate target analytes with shorter urinary excretion time. Subsequently, urines from athletes tested positive for cannabis should be reanalyzed including these analytes. Methods: In an one-session clinical trial (approved by IRB, Swissmedic, and Federal Office of Public Health), 12 healthy, male volunteers (age 26 ± 3 yrs, BMI 24 ± 2 kg/m2) with cannabis experience (&gt; once/month) smoked a Cannabis cigarette standardized to 70 mg THC/cigarette (Bedrobinol® 7%, Dutch Office for Medicinal Cannabis) following a paced-puffing procedure. Plasma and urine was collected up to 8 h and 11 days, respectively. Total THC, 11-hydroxy-THC (THC-OH), and THC-COOH were determined after enzymatic hydrolyzation followed by SPE and GC/MS-SIM. The limit of quantitation (LOQ) for all analytes was 0.1 ng/mL. Visual analog scales (VAS) and vital functions were used for monitoring psychological and somatic side-effects at every timepoint of specimen collection (up to 480 min). Results: Eight puffs delivered a mean THC dose of 45 mg. Mean plasma levels of total THC, THC-OH and THC-COOH were measured in the range of 0.1-20.9, 0.1-1.8, and 1.8-7.5 ng/mL, respectively. Peak concentrations were observed at 5, 10, and 90 min. Mean urine levels were measured in the range of 0.1-0.7, 0.10-6.2, and 0.1-13.4 ng/mL, respectively. The detection windows were 2-8, 2-96, and 2-120 h. No or only mild effects were observed, such as dry mouth, sedation, and tachycardia. Besides high to very high THC-COOH levels (0-978 ng/mL), THC (0.1-24 ng/mL) and THC-OH (1-234 ng/mL) were found in 90 and 96% of the cannabis-positive urines from athletes. Conclusion: Instead of or in addition to THC-COOH, the pharmacologically active THC and THC-OH should be the target analytes for doping urine analysis. This would allow the estimation of more recent Cannabis consumption, probably influencing performance during competition. Keywords: cannabis, doping, clinical trial, plasma and urine levels, athlete's sample

Current sedation and monitoring practice for colonoscopy: an international observational study (EPAGE)

BACKGROUND AND STUDY AIMS: Sedation and monitoring practice during colonoscopy varies between centers and over time. Knowledge of current practice is needed to ensure quality of care and help focus future research. The objective of this study was to examine sedation and monitoring practice in endoscopy centers internationally. PATIENTS AND METHODS: This observational study included consecutive patients referred for colonoscopy at 21 centers in 11 countries. Endoscopists reported sedation and monitoring practice, using a standard questionnaire for each patient. RESULTS: 6004 patients were included in this study, of whom 53 % received conscious/moderate sedation during colonoscopy, 30 % received deep sedation, and 17 % received no sedation. Sedation agents most commonly used were midazolam (47 %) and opioids (33 %). Pulse oximetry was done during colonoscopy in 77 % of patients, blood pressure monitoring in 34 %, and electrocardiography in 24 %. Pulse oximetry was most commonly used for moderately sedated patients, while blood pressure monitoring and electrocardiography were used predominantly for deeply sedated patients. Sedation and monitoring use ranged from 0 % to 100 % between centers. Oxygen desaturation (&lt;/= 85 %) occurred in 5 % of patients, of whom 80 % were moderately sedated. On average, three staff members were involved in procedures. An anesthesiologist was present during 27 % of colonoscopies, and during 85 % of colonoscopies using deep sedation. CONCLUSIONS: Internationally, sedation and monitoring practice during colonoscopy varied widely. Moderate sedation was the most common sedation method used and electronic monitoring was used in three-quarters of patients. Deep sedation tended to be more resource-intensive, implying a greater use of staff and monitoring. [Authors]]]> Colonoscopy ; Conscious Sedation ; Hypnotics and Sedatives ; Monitoring, Physiologic ; Physician's Practice Patterns oai:serval.unil.ch:BIB_254F2604090A 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_254F2604090A Simulating fully-integrated hydrological dynamics in complex Alpine headwaters info:doi:10.31223/X5RG7Q info:eu-repo/semantics/altIdentifier/doi/10.31223/X5RG7Q https://doi.org/10.31223/X5RG7Q James, Thornton René, Therrien Grégoire, Mariéthoz Niklas, Linde Philip, Brunner info:eu-repo/semantics/other misc 2021-02-26 eng oai:serval.unil.ch:BIB_255 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_255 High Pressure Techniques in Chemistry and Physics: Spectroscopic Measurements: NMR. Helm, L Powell, D.H. Merbach, A.E. info:eu-repo/semantics/bookPart incollection 1997 Practical Approach Series, pp. 187-216 oai:serval.unil.ch:BIB_2549 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_2549 Paul Tillich et l'histoire de l'art. Reymond, B info:eu-repo/semantics/article article 1997 RThPh, pp. 67-74 oai:serval.unil.ch:BIB_25490 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_25490 Actualité de la Convention européenne des droits de l'homme, mai 2002 - octobre 2002. Flauss, JF info:eu-repo/semantics/article article 2002 Actualité juridique de droit administratif, vol. 20, pp. 1277-1286 oai:serval.unil.ch:BIB_25491 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_25491 Le statut pénal du Président de la République et la Convention européenne des droits de l'homme. Flauss, JF info:eu-repo/semantics/article article 2002 Les Petites Affiches, vol. 261, pp. 4-10 oai:serval.unil.ch:BIB_25492 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_25492 Du droit international comparé de droits de l'homme dans la jurisprudence de la Cour européenne des droits de l'homme. Flauss, JF info:eu-repo/semantics/bookPart incollection 2002 Le rôle du droit comparé dans l'avènement du droit européen, vol. 43, pp. 159-182 Widmer, P. (ed.) oai:serval.unil.ch:BIB_25493 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_25493 Dualisme juridictionnel et Convention européenne des droits de l'homme. Flauss, JF info:eu-repo/semantics/bookPart incollection 2002 Liber amicorum J. Waline, Gouverner, administrer, juger, pp. 523-546 oai:serval.unil.ch:BIB_25494 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_25494 Pathologies infectieuses en réanimation Charbonneau, P Praz, G Glauser, M.P info:eu-repo/semantics/book book 2002 oai:serval.unil.ch:BIB_25495 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_25495 La primauté des droits de l'homme : licéité ou illicéité de l'intervention humanitaire. Flauss, JF info:eu-repo/semantics/bookPart incollection 2002 Le Kosovo et la Communauté internationale - L'histoire, l'actualité et l'avenir. Kosovo and the International Community, pp. 87-102 Tomuschat, C (ed.) oai:serval.unil.ch:BIB_254951546C6B 2022-05-07T01:13:03Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_254951546C6B MR gated subtraction angiography: evaluation of lower extremities info:eu-repo/semantics/altIdentifier/pmid/3961174 Meuli, R. A. Wedeen, V. J. Geller, S. C. Edelman, R. R. Frank, L. R. Brady, T. J. Rosen, B. R. info:eu-repo/semantics/article article 1986-05 Radiology, vol. 159, no. 2, pp. 411-8 info:eu-repo/semantics/altIdentifier/pissn/0033-8419 <![CDATA[We report the first clinical experience with a new method for projective imaging of blood vessels (angiography) using magnetic resonance. Vascular contrast is produced noninvasively by the phase response of moving protons. Diastolic and systolic gated images produce, respectively, flow signal and flow void; the difference image is a map of the pulsatile flow: an arteriogram. Preliminary studies are presented of the lower extremities of one healthy volunteer and four patients (one each with occlusive disease, soft-tissue tumor, arteriovenous malformation, and venous femoral-popliteal graft). Patient data are compared with accompanying conventional arteriograms, and the new method is discussed

The appropriateness of colonoscopy: a multi-center, international, observational study

OBJECTIVE: To examine the appropriateness and necessity of colonoscopy across Europe. DESIGN: Prospective observational study. SETTING: A total of 21 gastrointestinal centers from 11 countries. PARTICIPANTS: Consecutive patients referred for colonoscopy at each center. INTERVENTION: Appropriateness criteria developed by the European Panel on the Appropriateness of Gastrointestinal Endoscopy, using the RAND appropriateness method, were used to assess the appropriateness of colonoscopy. MAIN OUTCOMME MEASURE: Appropriateness of colonoscopy. RESULTS: A total of 5213 of 6004 (86.8%) patients who underwent diagnostic colonoscopy and had an appropriateness rating were included in this study. According to the criteria, 20, 26, 27, or 27% of colonoscopies were judged to be necessary, appropriate, uncertain, or inappropriate, respectively. Older patients and those with a major illness were more likely to have an appropriate or necessary indication for colonoscopy as compared to healthy patients or patients who were 45-54 years old. As compared to screening patients, patients who underwent colonoscopy for iron-deficiency anemia [OR: 30.84, 95% CI: 19.79-48.06] or change in bowel habits [OR: 3.69, 95% CI: 2.74-4.96] were more likely to have an appropriate or necessary indication, whereas patients who underwent colonoscopy for abdominal pain [OR: 0.64, 95% CI: 0.49-0.83] or chronic diarrhea [OR: 0.54, 95% CI: 0.40-0.75] were less likely to have an appropriate or necessary indication. CONCLUSIONS: This study identified significant proportions of inappropriate colonoscopies. Prospective use of the criteria by physicians referring for or performing colonoscopies may improve appropriateness and quality of care, especially in younger patients and in patients with nonspecific symptoms

The CoLaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome

<p>Abstract</p> <p>Background</p> <p>Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess the prevalence of cardiovascular risk factors (CVRFs) in the Caucasian population of Lausanne, Switzerland, we conducted a population-based study (Colaus Study). A secondary aim of the CoLaus study will be to determine new genetic determinants associated with CVRFs.</p> <p>Methods</p> <p>Single-center, cross-sectional study including a random sample of 6,188 extensively phenotyped Caucasian subjects (3,251 women and 2,937 men) aged 35 to 75 years living in Lausanne, and genotyped using the 500 K Affymetrix chip technology.</p> <p>Results</p> <p>Obesity (body mass index ≥ 30 kg/m²), smoking, hypertension (blood pressure ≥ 140/90 mmHg and/or treatment), dyslipidemia (high LDL-cholesterol and/or low HDL-cholesterol and/or high triglyceride levels) and diabetes (fasting plasma glucose ≥ 7 mmol/l and/or treatment) were present in 947 (15.7%), 1673 (27.0%), 2268 (36.7%), 2113 (34.2%) and 407 (6.6%) of the participants, respectively, and the prevalence was higher in men than in women. In both genders, the prevalence of obesity, hypertension and diabetes increased with age.</p> <p>Conclusion</p> <p>The prevalence of major CVRFs is high in the Lausanne population in particular in men. We anticipate that given its size, the depth of the phenotypic analysis and the availability of dense genome-wide genetic data, the CoLaus Study will be a unique resource to investigate not only the epidemiology of isolated, or aggregated CVRFs like the metabolic syndrome, but can also serve as a discovery set, as well as replication set, to identify novel genes associated with these conditions.</p