213 research outputs found
Quantification of depth of anesthesia by nonlinear time series analysis of brain electrical activity
We investigate several quantifiers of the electroencephalogram (EEG) signal
with respect to their ability to indicate depth of anesthesia. For 17 patients
anesthetized with Sevoflurane, three established measures (two spectral and one
based on the bispectrum), as well as a phase space based nonlinear correlation
index were computed from consecutive EEG epochs. In absence of an independent
way to determine anesthesia depth, the standard was derived from measured blood
plasma concentrations of the anesthetic via a pharmacokinetic/pharmacodynamic
model for the estimated effective brain concentration of Sevoflurane. In most
patients, the highest correlation is observed for the nonlinear correlation
index D*. In contrast to spectral measures, D* is found to decrease
monotonically with increasing (estimated) depth of anesthesia, even when a
"burst-suppression" pattern occurs in the EEG. The findings show the potential
for applications of concepts derived from the theory of nonlinear dynamics,
even if little can be assumed about the process under investigation.Comment: 7 pages, 5 figure
Recommended from our members
Overview of mathematical approaches used to model bacterial chemotaxis II: bacterial populations
We review the application of mathematical modeling to understanding the behavior of populations of chemotactic bacteria. The application of continuum mathematical models, in particular generalized Keller–Segel models, is discussed along with attempts to incorporate the microscale (individual) behavior on the macroscale, modeling the interaction between different species of bacteria, the interaction of bacteria with their environment, and methods used to obtain experimentally verified parameter values. We allude briefly to the role of modeling pattern formation in understanding collective behavior within bacterial populations. Various aspects of each model are discussed and areas for possible future research are postulated
Methods of electroencephalographic signal analysis for detection of small hidden changes
The aim of this study was to select and evaluate methods sensitive to reveal small hidden changes in the electroencephalographic (EEG) signal. Two original methods were considered
Agonistic Interventions into Public Commemorative Art:An Innovative Form of Counter-memorial Practice?
In light of recent controversies around the removal or modification of public commemorative art, such as memorials and monuments, this paper interrogates the value of competing approaches to counter-memorial practice using the framework of agonistic memory. It argues that much counter-memorial practice today, as it relates to historical memory, is dominated by a “cosmopolitan” mode that fails to offer a convincing response to the rise of right-wing populism and its instrumentalization of conflicts over public commemorative art. The article investigates two case studies of counter-memorial interventions that focus on the memory of fascism in Europe today and seeks to identify and assess emergent agonistic practices
Ethylene/1-olefin copolymerization behaviour of vanadium and titanium complexes bearing salen-type ligand
Effects of the timing of tourniquet release in cemented total knee arthroplasty: a systematic review and meta-analysis of randomized controlled trials
Construction of yellow fever virus subgenomic replicons by yeast-based homologous recombination cloning technique
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation
Although oxidative tissue injury often accompanies viral infection, there is little understanding of how it influences virus replication. We show that multiple hepatitis C virus (HCV) genotypes are exquisitely sensitive to oxidative membrane damage, a property distinguishing them from other pathogenic RNA viruses. Lipid peroxidation, regulated in part through sphingosine kinase 2, severely restricts HCV replication in Huh-7 cells and primary human hepatoblasts. Endogenous oxidative membrane damage lowers the 50% effective concentration of direct-acting antivirals, suggesting critical regulation of the conformation of the NS3/4A protease and NS5B polymerase, membrane-bound HCV replicase components. Resistance to lipid peroxidation maps genetically to trans-membrane and membrane-proximal residues within these proteins, and is essential for robust replication in cell culture, as exemplified by the atypical JFH1 strain. Thus, the typical, wild-type HCV replicase is uniquely regulated by lipid peroxidation, providing a novel mechanism for attenuating replication in stressed tissue and possibly facilitating long-term viral persistence
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. / METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). / RESULTS: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. / CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.
Connecting the dots: social network structure, conflict, and group cognitive complexity
- …