Terapi Topikal Clindamycin Dibandingkan Dengan Niacinamide + Zinc Pada Acne Vulgaris

Latar Belakang: Pengobatan antibiotik topical untuk menangani akne vulgaris sudah sering digunakan, salah satunya adalah Clindamycin 1 %. Namun demikian, penggunaan antibiotic ini secara luas diperkirakan memunculkan strain P. Acnes yang resistan terhadap clindamycin. Kombinasi niacinamide dan zinc berfungsi sebagai anti inflamasi, menurunkan produksi sebum, dan mencegah timbulnya bekas luka jerawat. Niacinamide + zinc dapat mengatasi jerawat tanpa menimbulkan resistansi bakteri P. Acnes.Tujuan: Mengetahui perbedaan efektivitas clindamycin dan niacinamide+zinc dalam mengurangi jumlah jerawat.Metode: Jenis penelitian ini adalah experimental dengan rancangan randomized control trial – double blind. Sampel adalah penderita akne derajat mild – moderate yang tercatat sebagai mahasiswa Fakultas Kedokteran UNDIP dengan rentang usia 18 – 25 tahun. Empat puluh orang dibagi menjadi 2 kelompok secara acak untuk mendapat pengobatan clindamycin atau niacinamide + zinc, digunakan 2 kali sehari selama 2 minggu. Evaluasi pengobatan dengan menghitung rata - rata penurunan jumlah lesi pada tiap kelompok. Data pada masing – masing kelompok terapi dianalisis dengan one sample t – test sedangkan untuk mengetahui perbandingan efektivitas antara dua kelompok menggunakan analisis independent t - test.Hasil: Jumlah lesi pada kelompok terapi clindamycin (p= 0,00) dan niacinamide+zinc (p= 0,008) mengalami penurunan yang sangat bermakna (p<0,05). Rerata proporsi kesembuhan pada kelompok clindamycin sebesar 69% sedangkan kelompok niacinamide+zinc sebesar 64,20%. Tidak ada perbedaan efektivitas yang bermakna antara dua kelompok terapi (p= 0,620 ; p > 0,05).Simpulan: Clindamycin topical dan niacinamide+zinc topical sama – sama efektif menurunkan jumlah lesi jerawa

Aktivitas Antioksidan Dan Toksisitas Ekstrak Air Dan Etanol Daun Benalu (Dendrophthoe Pentandra L. Miq) Yang Tumbuh Pada Berbagai Inang

Mistletoes are used traditionally in Indonesiaas medicinal plant, one of this as anticancer. Cancer isone of degenerative diseases could be triggered by toomuch free radicals in the body, whereas antioxidantcould reduced the risk of degenerative diseases.Mistletoes reposted content flavonoids which known have antioxidant activity. Mistletoe potency as drugmaterial should be studied sa the utilization ofmistletoe could be developed. Antioxidant activitytest using "DPPH free radical scavenger" methodand toxicity test using BSLT (Brine Shrimp LethalityTest) method had been conducted on water andethanol extracts of mistletoe Dendropthoe pentandra(L.) Miq.) that grown on various trees (star fruit,mango, cananga, 'duku, sour-sop, kepel, mahkotadewa, and tea). The result showed that ethanol andwater extracte-ofD, petandra on all host plants haveantioxidant activity (IC50 value between 6.4 - 51.8ug/mL). The result of toxicity test showed that ethanolextract of mistletoe on cananga, starfruit, kepel andmahkota dewa host plants have toxicity effect againstA. salina larvae with LCso value below 1000 ug/mL,nevertheless ethanol extract on others host plants andwater extract didn It give toxicity effect against A.salina larvae (LC50 > 1000 ug/mL)

EFFECTS OF BLACK SEEDS EXTRACTS SUPPLEMENTATION ON IFNΓ LEVEL OF MULTIBACILLARY LEPROSY PATIENTS RECEIVING WHO-MDT

Background: Multibacillary leprosy patients exhibit a defective CMI response to M. leprae thereby causing a high bacillary load and lots of skin lesions, making untreated multibacillary patients becoming main reservoir and transmission of M.leprae. Th2 cytokines like IL-4, IL-5 and IL-10 elevated anc becoming characteristic of lepromatous or multibacillar patiens, with low level of Th1 cytokines, including IFN-g. Several studies showed that black seeds enhanced the production of IFN γ , posses potent potentiating effects on the CMI/ stimualtory effect on Th1 cells, while posses suppressor effects on humoral immunity/ inhibitory effect on Th2 cells. The purpose of this study is to know the effects of black seeds extract supplementation on IFN γ level of multibacillary leprosy patients. Methods: this study is experimental research with randomized controlled trial design. A sample of 44 patients was randomized into 2 groups: (i) placebo group, receiving WHO-MDT  and palcebo, (ii) black seed goup, receiving WHO-MDT and black seed extracts. The independent variable was the WHO-MDT plus black seed supplementation (3000 mg), and WHO-MDT plus placebo given  for 2 months . The dependent variable was IFN γ level. Results: Mean level of IFN γ before and after study from black seed groups was significantly different (p<0,0001), and mean delta value of black seed group was significantly superior (p=0,005/ p<0,05) to that of placebo. Conclusion: supplementation with black seeds extracts can enhance IFNγ production of multibacillary leprosy patients. Keywords: MB Leprosy, black seeds extract, Nigella sativa, IFN