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Rapid Response of an Academic Surgical Department to the COVID-19 Pandemic: Implications for Patients, Surgeons, and the Community.
BackgroundAs the coronavirus disease 2019 (COVID-19) pandemic continues to spread, swift actions and preparation are critical for ensuring the best outcomes for patients and providers. We aim to describe our hospital and Department of Surgery's experience in preparing for the COVID-19 pandemic and caring for surgical patients during this unprecedented time.Study designThis is a descriptive study outlining the strategy of a single academic health system for addressing the following 4 critical issues facing surgical departments during the COVID-19 pandemic: developing a cohesive leadership team and system for frequent communication throughout the department; ensuring adequate hospital capacity to care for an anticipated influx of COVID-19 patients; safeguarding supplies of blood products and personal protective equipment to protect patients and providers; and preparing for an unstable workforce due to illness and competing personal priorities, such as childcare.ResultsThrough collaborative efforts within the Department of Surgery and hospital, we provided concise and regular communication, reduced operating room volume by 80%, secured a 4-week supply of personal protective equipment, and created reduced staffing protocols with back-up staffing plans.ConclusionsBy developing an enabling infrastructure, a department can nimbly respond to crises like COVID-19 by promoting trust among colleagues and emphasizing an unwavering commitment to excellent patient care. Sharing principles and practical applications of these changes is important to optimize responses across the country and the world
Zeno Dynamics of von Neumann Algebras
The dynamical quantum Zeno effect is studied in the context of von Neumann
algebras. We identify a localized subalgebra on which the Zeno dynamics acts by
automorphisms. The Zeno dynamics coincides with the modular dynamics of that
subalgebra, if an additional assumption is satisfied. This relates the modular
operator of that subalgebra to the modular operator of the original algebra by
a variant of the Kato-Lie-Trotter product formula.Comment: Revised version; further typos corrected; 9 pages, AMSLaTe
Electric dipole rovibrational transitions in HD molecule
The rovibrational electric dipole transitions in the ground electronic state
of the HD molecule are studied. A simple, yet rigorous formula is derived for
the transition rates in terms of the electric dipole moment function ,
which is calculated in a wide range of . Our numerical results for
transition rates are in moderate agreement with experiments and previous
calculations, but are at least an order of magnitude more accurate.Comment: 7 pages, 1 figur
Classical simulation of noninteracting-fermion quantum circuits
We show that a class of quantum computations that was recently shown to be
efficiently simulatable on a classical computer by Valiant corresponds to a
physical model of noninteracting fermions in one dimension. We give an
alternative proof of his result using the language of fermions and extend the
result to noninteracting fermions with arbitrary pairwise interactions, where
gates can be conditioned on outcomes of complete von Neumann measurements in
the computational basis on other fermionic modes in the circuit. This last
result is in remarkable contrast with the case of noninteracting bosons where
universal quantum computation can be achieved by allowing gates to be
conditioned on classical bits (quant-ph/0006088).Comment: 26 pages, 1 figure, uses wick.sty; references added to recent results
by E. Knil
Improvement in efficiency of the electrocatalytic reduction of hydrogen peroxide by prussian blue produced from the [Fe(CN)5(mpz)]2â complex
Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior (CAPES)Hydrogen peroxide is one of the most important molecules in chemical signaling in living organisms. Because of this, its sensing is indispensable for the diagnosis of many diseases. Among the materials used for the detection and quantification of H2O2, Prussian Blue (PB) has been highlighted due to its performance. Therefore, the search for alternatives or the improvement of PB performance is a challenge. In this context, our motivation was to evaluate how the ligand N-methylpyrazinium affects the structure and reactivity of Prussian Blue films produced from [Fe(CN)(5)(mpz)](2-) (PB-mpz). Based on the results, it was possible to conclude that the ligand is coordinated to the complex inside the PB framework and consequently contributes to the generation of a noncrystalline structure. The ions contained in buffer solutions can react with Prussian Blue by binding to Fe3+ and breaking the structure. In addition, a PB-mpz film in HCl/KCl showed higher sensitivity towards H2O2 than a PB film.Hydrogen peroxide is one of the most important molecules in chemical signaling in living organisms. Because of this, its sensing is indispensable for the diagnosis of many diseases. Among the materials used for the detection and quantification of H2O2, Pr20171319791988CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTĂFICO E TECNOLĂGICO - CNPQFUNDAĂĂO DE AMPARO Ă PESQUISA DO ESTADO DE SĂO PAULO - FAPESPCOORDENAĂĂO DE APERFEIĂOAMENTO DE PESSOAL DE NĂVEL SUPERIOR - CAPESConselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior (CAPES)459923/2014â52013/22127â2sem informaçãoThe authors acknowledge the financial support of the Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq) (grant no. 459923/2014â5), the Fundo de Apoio ao Ensino, Ă Pesquisa e Ă ExtensĂŁo â Universidade Estadual de Campinas (FAEPEXâUNICAMP
Spectral Properties of delta-Plutonium: Sensitivity to 5f Occupancy
By combining the local density approximation (LDA) with dynamical mean field
theory (DMFT), we report a systematic analysis of the spectral properties of
-plutonium with varying occupancy. The LDA Hamiltonian is
extracted from a tight-binding (TB) fit to full-potential linearized augmented
plane-wave (FP-LAPW) calculations. The DMFT equations are solved by the exact
quantum Monte Carlo (QMC) method and the Hubbard-I approximation. We have shown
for the first time the strong sensitivity of the spectral properties to the
occupancy, which suggests using this occupancy as a fitting parameter in
addition to the Hubbard . By comparing with PES data, we conclude that the
``open shell'' configuration gives the best agreement, resolving the
controversy over ``open shell'' versus ``close shell'' atomic
configurations in -Pu.Comment: 6 pages, 2 embedded color figures, to appear in Physical Review
Relativistic calculation of the triton binding energy and its implications
First results for the triton binding energy obtained from the relativistic
spectator or Gross equation are reported. The Dirac structure of the nucleons
is taken into account. Numerical results are presented for a family of
realistic OBE models with off-shell scalar couplings. It is shown that these
off-shell couplings improve both the fits to the two-body data and the
predictions for the binding energy.Comment: 5 pages, RevTeX 3.0, 1 figure (uses epsfig.sty
The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation
ABSTRACTCoordination between different cytoskeletal systems is crucial for many cell biological functions, including cell migration and mitosis, and also plays an important role during tissue morphogenesis. Proteins of the class of cytoskeletal crosslinkers, or cytolinkers, have the ability to interact with more than one cytoskeletal system at a time and are prime candidates to mediate any coordination. One such class comprises the Gas2-like proteins, combining a conserved calponin-homology-type actin-binding domain and a Gas2 domain predicted to bind microtubules (MTs). This domain combination is also found in spectraplakins, huge cytolinkers that play important roles in many tissues in both invertebrates and vertebrates. Here, we dissect the ability of the single Drosophila Gas2-like protein Pigs to interact with both actin and MT cytoskeletons, both in vitro and in vivo, and illustrate complex regulatory interactions that determine the localisation of Pigs to and its effects on the cytoskeleton.Summary: Detailed analysis of the ability of the Drosophila cytolinker protein Pigs to modulate its cytoskeleton-interacting functions (+TIP tracking, microtubule shaft binding, actin binding and actinâmicrotubule crosslinking)
Non-Abelian Monopole and Dyon Solutions in a Modified Einstein-Yang-Mills-Higgs System
We have studied a modified Yang-Mills-Higgs system coupled to Einstein
gravity. The modification of the Einstein-Hilbert action involves a direct
coupling of the Higgs field to the scalar curvature. In this modified system we
are able to write a Bogomol'nyi type condition in curved space and demonstrate
that the positive static energy functional is bounded from below. We then
investigate non-Abelian sperically symmetric static solutions in a similar
fashion to the `t Hooft-Polyakov monopole. After reviewing previously studied
monopole solutions of this type, we extend the formalism to included electric
charge and we present dyon solutions.Comment: 18 pages LaTeX, 7 eps-figure
Release of copper-amended particles from micronized copper-pressure-treated wood during mechanical abrasion
Background: We investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for lung cells. The data were compared with particles released after abrasion of untreated, water (0% MCA)-pressure-treated, chromated copper (CC)-pressure-treated wood, and varnished wood. Size, morphology, and composition of the released particles were analyzed. Results: Our results indicate that the abrasion of MCA-pressure-treated wood does not cause an additional release of nanoparticles from the unreacted copper (Cu) carbonate nanoparticles from of the MCA formulation. However, a small amount of released Cu was detected in the nanosized fraction of wood dust, which could penetrate the deep lungs. The acute cytotoxicity studies were performed on a human lung epithelial cell line and human macrophages derived from a monocytic cell line. These cell types are likely to encounter the released wood particles after inhalation. Conclusions: Our findings indicate that under the experimental conditions chosen, MCA does not pose a specific additional nano-risk, i.e. there is no additional release of nanoparticles and no specific nano-toxicity for lung epithelial cells and macrophages
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