Evaluation of Reorientation Techniques and Distractors for Walking in Large Virtual Environments

Virtual Environments (VEs) that use a real-walking locomotion interface have typically been restricted in size to the area of the tracked lab space. Techniques proposed to lift this size constraint, enabling real walking in VEs that are larger than the tracked lab space, all require reorientation techniques (ROTs) in the worst-case situation–when a user is close to walking out of the tracked space. We propose a new ROT using visual and audial distractors–objects in the VE that the user focuses on while the VE rotates–and compare our method to current ROTs through three user studies. ROTs using distractors were preferred and ranked more natural by users. Users were also less aware of the rotating VE when ROTs with distractors were used. Our findings also suggest that improving visual realism and adding sound increased a user's feeling of presence

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Inhibited coarsening of a sprayformed and extruded hypereutectic aluminium-silicon alloy in the semi-solid state

The microstructural evolution of a sprayformed and extruded hypereutectic aluminium-30% silicon-5% copper-2% magnesium alloy heated into the semi-solid state has been investigated. Liquid is formed initially by a quaternary eutectic reaction and then by a ternary melt reaction. These reactions occur relatively quickly. However, the binary Al-Si eutectic melt reaction takes a significant time – around several hours depending on the temperature. The coarsening rate constants (K) for the growth of the silicon particles are approximately 3 to 4 orders of magnitude lower than those for the majority of metal sprayformed alloys. This may be associated with difficulties in addition or removal of atoms from the low index silicon facets. Where growth does occur, agglomeration of silicon particles may play a large role, especially at higher liquid contents. Electron backscatter diffraction (EBSD) gives evidence of agglomeration, and furthermore shows that high angle silicon-silicon boundaries are not wetted with liquid