Community Resilience Through Crisis At El Infiernito, Chiapas, A Fortified Refuge In The Upper Usumacinta Valley

Collapse has been misunderstood to equate with the disappearance of civilizations, but political fragmentation is merely one aspect of the complex processes of social transformation. Other concepts, including resilience are useful to separate the effects of cultural continuity from political disintegration. This study approaches these topics from the level of an archaeological community or hamlet located at the periphery of a dynastic center or state. I present 4 broad arguments: 1) collapse and resilience are evolving processes best understood as different aspects of social transformation, 2) the role of agency in collapse and resilience studies is underappreciated, 3) lower elite and commoner populations play a role in these political dynamics, and 4) the changing relationship between dynastic centers and outlying communities is negotiated over time rather than static. The cultural context of this study is the political transformation at the end of the Classic period (AD 250–900) in the Southern Maya Lowlands that involved, in part, political fragmentation or collapse. The timing of this Classic period (AD 250–900) collapse in the Maya area has been informed by long count calendar dates on the final monuments of dynastic and subsidiary centers. However, archaeologists have noted that the subsequent demographic decline in the Southern Lowlands was a protracted process that operated at diverse rates across different subregions. I address these issues with a middle or community-level approach through settlement survey and the excavation of El Infiernito, a hamlet roughly equidistant from the Classic period dynastic center Piedras Negras and its subsidiary ally La Mar. Crucial to the resilience of the El Infiernito community was the reoccupation of a hilltop first modified during the Protoclassic period (100 BC–AD 350) and the construction and maintenance of defensive features to protect the site, agricultural terraces, and a karst spring. Further strategies involved the construction of C-shaped benches and subdivision of living space, ancestor veneration and other household rituals, accessing shifting trade networks, and controlling access to ritual caves. El Infiernito, therefore, provides a rare glimpse of the transition from the Terminal Classic to Early Postclassic periods in the Upper Usumacinta Basin

The Digital Revolution to Come: Photogrammetry in Archaeological Practice

The three-dimensional (3D) revolution promised to transform archaeological practice. Of the technologies that contribute to the proliferation of 3D data, photogrammetry facilitates the rapid and inexpensive digitization of complex subjects in both field and lab settings. It finds additional use as a tool for public outreach, where it engages audiences ranging from source communities to artifact collectors. But what has photogrammetry’s function been in advancing archaeological analysis? Drawing on our previous work, we review recent applications to understand the role of photogrammetry for contemporary archaeologists. Although photogrammetry is widely used as a visual aid, its analytical potential remains underdeveloped. Considering various scales of inquiry—graduating from objects to landscapes—we address how the technology fits within and expands existing documentation and data visualization routines, while evaluating the opportunity it presents for addressing archaeological questions and problems in innovative ways. We advance an agenda advocating that archaeologists move from proof-of concept papers toward greater integration of photogrammetry with research

Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

BackgroundThe O 6 -methylguanine methyltransferase (MGMT) gene is frequently unmethylated in patients with glioblastoma (GBM), rendering them non-responsive to the standard treatment regime of surgery followed by concurrent radiotherapy (RT) and temozolomide. Here, we investigate the efficacy of adding a PARP inhibitor, veliparib, to radiotherapy to treat MGMT unmethylated GBM.MethodsThe inhibition of PARP with veliparib (ABT-888), a potent and orally bioavailable inhibitor in combination with RT was tested on a panel of patient derived cell lines (PDCLs) and patient-derived xenografts (PDX) models generated from GBM patients with MGMT unmethylated tumors.ResultsThe combination of veliparib and RT inhibited colony formation in the majority of PDCLs tested. The PDCL, RN1 showed significantly reduced levels of the homologous repair protein, Mre11 and a heightened response to PARP inhibition measured by increased apoptosis and decreased colony formation. The oral administration of veliparib (12.5 mg/kg, twice daily for 5 days in a 28-day treatment cycle) in combination with whole brain RT (4 Gy) induced apoptosis (Tunel staining) and decreased cell proliferation (Ki67 staining) in a PDX of MGMT unmethylated GBM. Significantly longer survival times of the PDX treated with the combination treatment were recorded compared to RT only or veliparib only.ConclusionsOur results demonstrate preclinical efficacy of targeting PARP at multiple levels and provide a new approach for the treatment of MGMT unmethylated GBM.<br /

Phylogenetic Relationships among the Colobine Monkeys Revisited: New Insights from Analyses of Complete mt Genomes and 44 Nuclear Non-Coding Markers

Background: Phylogenetic relationships among Asian and African colobine genera have been disputed and are not yet well established. In the present study, we revisit the contentious relationships within the Asian and African Colobinae by analyzing 44 nuclear non-coding genes (.23 kb) and mitochondrial (mt) genome sequences from 14 colobine and 4 noncolobine primates. Principal Findings: The combined nuclear gene and the mt genome as well as the combined nuclear and mt gene analyses yielded different phylogenetic relationships among colobine genera with the exception of a monophyletic ‘odd-nosed’ group consisting of Rhinopithecus, Pygathrix and Nasalis, and a monophyletic African group consisting of Colobus and Piliocolobus. The combined nuclear data analyses supported a sister-grouping between Semnopithecus and Trachypithecus, and between Presbytis and the odd-nosed monkey group, as well as a sister-taxon association of Pygathrix and Rhinopithecus within the odd-nosed monkey group. In contrast, mt genome data analyses revealed that Semnopithecus diverged earliest among the Asian colobines and that the odd-nosed monkey group is sister to a Presbytis and Trachypithecus clade, as well as a close association of Pygathrix with Nasalis. The relationships among these genera inferred from the analyses of combined nuclear and mt genes, however, varied with the tree-building methods used. Another remarkable finding of the present study is that all of our analyses rejected the recently proposed African colobine paraphyl

UAV LiDAR Survey for Archaeological Documentation in Chiapas, Mexico

Airborne laser scanning has proven useful for rapid and extensive documentation of historic cultural landscapes after years of applications mapping natural landscapes and the built environment. The recent integration of unoccupied aerial vehicles (UAVs) with LiDAR systems is potentially transformative and offers complementary data for mapping targeted areas with high precision and systematic study of coupled natural and human systems. We report the results of data capture, analysis, and processing of UAV LiDAR data collected in the Maya Lowlands of Chiapas, Mexico in 2019 for a comparative landscape study. Six areas of archaeological settlement and long-term land-use reflecting a diversity of environments, land cover, and archaeological features were studied. These missions were characterized by areas that were variably forested, rugged, or flat, and included pre-Hispanic settlements and agrarian landscapes. Our study confirms that UAV LiDAR systems have great potential for broader application in high-precision archaeological mapping applications. We also conclude that these studies offer an important opportunity for multi-disciplinary collaboration. UAV LiDAR offers high-precision information that is not only useful for mapping archaeological features, but also provides critical information about long-term land use and landscape change in the context of archaeological resources

UAV LiDAR Survey for Archaeological Documentation in Chiapas, Mexico

Airborne laser scanning has proven useful for rapid and extensive documentation of historic cultural landscapes after years of applications mapping natural landscapes and the built environment. The recent integration of unoccupied aerial vehicles (UAVs) with LiDAR systems is potentially transformative and offers complementary data for mapping targeted areas with high precision and systematic study of coupled natural and human systems. We report the results of data capture, analysis, and processing of UAV LiDAR data collected in the Maya Lowlands of Chiapas, Mexico in 2019 for a comparative landscape study. Six areas of archaeological settlement and long-term land-use reflecting a diversity of environments, land cover, and archaeological features were studied. These missions were characterized by areas that were variably forested, rugged, or flat, and included pre-Hispanic settlements and agrarian landscapes. Our study confirms that UAV LiDAR systems have great potential for broader application in high-precision archaeological mapping applications. We also conclude that these studies offer an important opportunity for multi-disciplinary collaboration. UAV LiDAR offers high-precision information that is not only useful for mapping archaeological features, but also provides critical information about long-term land use and landscape change in the context of archaeological resources

CCDC 191666: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures

CCDC 191665: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures