Nonminimal state space approach to multivariable ramp metering control of motorway bottlenecks

The paper discusses the automatic control of motorway traffic flows utilising ramp metering, i.e. traffic lights on the on-ramp entrances. A multivariable ramp metering system is developed, based on the nonminimal state space (NMSS) approach to control system design using adaptive proportional-integral-plus, linear quadratic (PIP–LQ) optimal controllers. The controller is evaluated on a nonlinear statistical traffic model (STM) simulation of the Amsterdam motorway ring road near the Coen Tunnel

X-Beam Alignment System

The goal of the project was to design, build, and test an automated machine for Micro-Vu that will align a pair of rails to the necessary precision and affix said rails to Micro-Vu\u27s X-Beam as to reduce manual labor and human error

Low-carbohydrate diets and men's cortisol and testosterone: Systematic review and meta-analysis

Background: Low-carbohydrate diets may have endocrine effects, although individual studies are conflicting. Therefore, a review was conducted on the effects of low- versus high-carbohydrate diets on men's testosterone and cortisol. Methods: The review was registered on PROSPERO (CRD42021255957). The inclusion criteria were: intervention study, healthy adult males, and low-carbohydrate diet: ≤35% carbohydrate. Eight databases were searched from conception to May 2021. Cochrane's risk of bias tool was used for quality assessment. Random-effects, meta-analyses using standardized mean differences and 95% confidence intervals, were performed with Review Manager. Subgroup analyses were conducted for diet duration, protein intake, and exercise duration. Results: Twenty-seven studies were included, with a total of 309 participants. Short-term (<3 weeks), low- versus high-carbohydrate diets moderately increased resting cortisol (0.41 [0.16, 0.66], p < 0.01). Whereas, long-term (≥3 weeks), low-carbohydrate diets had no consistent effect on resting cortisol. Low- versus high-carbohydrate diets resulted in much higher post-exercise cortisol, after long-duration exercise (≥20 min): 0 h (0.78 [0.47, 1.1], p < 0.01), 1 h (0.81 [0.31, 1.31], p < 0.01), and 2 h (0.82 [0.33, 1.3], p < 0.01). Moderate-protein (<35%), low-carbohydrate diets had no consistent effect on resting total testosterone, however high-protein (≥35%), low-carbohydrate diets greatly decreased resting (−1.08 [−1.67, −0.48], p < 0.01) and post-exercise total testosterone (−1.01 [−2, −0.01] p = 0.05). Conclusions: Resting and post-exercise cortisol increase during the first 3 weeks of a low-carbohydrate diet. Afterwards, resting cortisol appears to return to baseline, whilst post-exercise cortisol remains elevated. High-protein diets cause a large decrease in resting total testosterone (∼5.23 nmol/L)

Vascular physiology drives functional brain networks

We present the first evidence for vascular regulation driving fMRI signals in specific functional brain networks. Using concurrent neuronal and vascular stimuli, we collected 30 BOLD fMRI datasets in 10 healthy individuals: a working memory task, flashing checkerboard stimulus, and CO2 inhalation challenge were delivered in concurrent but orthogonal paradigms. The resulting imaging data were averaged together and decomposed using independent component analysis, and three “neuronal networks” were identified as demonstrating maximum temporal correlation with the neuronal stimulus paradigms: Default Mode Network, Task Positive Network, and Visual Network. For each of these, we observed a second network component with high spatial overlap. Using dual regression in the original 30 datasets, we extracted the time-series associated with these network pairs and calculated the percent of variance explained by the neuronal or vascular stimuli using a normalized R2 parameter. In each pairing, one network was dominated by the appropriate neuronal stimulus, and the other was dominated by the vascular stimulus as represented by the end-tidal CO2 time-series recorded in each scan. We acquired a second dataset in 8 of the original participants, where no CO2 challenge was delivered and CO2 levels fluctuated naturally with breathing variations. Although splitting of functional networks was not robust in these data, performing dual regression with the network maps from the original analysis in this new dataset successfully replicated our observations. Thus, in addition to responding to localized metabolic changes, the brain’s vasculature may be regulated in a coordinated manner that mimics (and potentially supports) specific functional brain networks. Multi-modal imaging and advances in fMRI acquisition and analysis could facilitate further study of the dual nature of functional brain networks. It will be critical to understand network-specific vascular function, and the behavior of a coupled vascular-neural network, in future studies of brain pathology

Chauffeur braking

An experienced driver will `feather' the brakes so as to unwind the suspension compliance and stop the vehicle with only just enough torque in the brakes to hold the vehicle stationary on any gradient, or against the residual torque from an automatic transmission’s torque converter. An optimal stopping problem that minimises the total jerk was formulated and solved. This model was extended by including a linear relationship between the brake pressure and the acceleration of the car where the coefficients are estimated by linear regression. Finally, a Kalman filter estimates the state of the car using the tone wheel

The functional connectivity between the nucleus accumbens and the ventromedial prefrontal cortex as an endophenotype for bipolar disorder

Background Alterations in functional connectivity between the nucleus accumbens (NAcc) and frontal cortices have been previously associated with the presence of psychiatric syndromes, among them bipolar disorder. Whether these alterations are a consequence or a risk factor for mental disorders remains unresolved. Methods This study included 35 bipolar participants, 30 of their resilient siblings, and 23 healthy controls to probe functional connectivity at rest between NAcc and the rest of the brain in a cross-sectional design. BOLD time series at rest from NAcc were used as seed-region in a woxel-wise correlational analysis. The strength of the correlations found were compared across groups after Fisher’s Z transformation. Results Our results showed increased functional connectivity between NAcc and a ventromedial prefrontal cortex (vmPFC) - comprising mainly the subgenual anterior cingulate - in patients compared to controls. Participants at increased genetic risk but yet resilient – i.e. unaffected siblings - showed functional connectivity values midway between the former two groups. Conclusions Our results are indicative of the potential for the connectivity between NAcc and the vmPFC to represent an endophenotype for bipolar disorder

Arterial CO2 fluctuations modulate neuronal rhythmicity: Implications for MEG and fMRI studies of resting-state networks

A fast emerging technique for studying human resting state networks (RSNs) is based on spontaneous temporal fluctuations in neuronal oscillatory power, as measured by magnetoencephalography. However, it has been demonstrated recently that this power is sensitive to modulations in arterial CO2 concentration. Arterial CO2 can be modulated by natural fluctuations in breathing pattern, as might typically occur during the acquisition of an RSN experiment. Here, we demonstrate for the first time the fine-scale dependence of neuronal oscillatory power on arterial CO2 concentration, showing that reductions in alpha, beta, and gamma power are observed with even very mild levels of hypercapnia (increased arterial CO2). We use a graded hypercapnia paradigm and participant feedback to rule out a sensory cause, suggesting a predominantly physiological origin. Furthermore, we demonstrate that natural fluctuations in arterial CO2, without administration of inspired CO2, are of a sufficient level to influence neuronal oscillatory power significantly in the delta-, alpha-, beta-, and gamma-frequency bands. A more thorough understanding of the relationship between physiological factors and cortical rhythmicity is required. In light of these findings, existing results, paradigms, and analysis techniques for the study of resting-state brain data should be revisited

Frame Indifferent Formulation of Maxwell's Elastic Fluid and the Rational Continuum Mechanics of the Electromagnetic Field

We show that the linearized equations of the incompressible elastic medium admit a `Maxwell form' in which the shear component of the stress vector plays the role of the electric field, and the vorticity plays the role of the magnetic field. Conversely, the set of dynamic Maxwell equations are strict mathematical corollaries from the governing equations of the incompressible elastic medium. This suggests that the nature of `electromagnetic field' may actually be related to an elastic continuous medium. The analogy is complete if the medium is assumed to behave as fluid in shear motions, while it may still behave as elastic solid under compressional motions. Then the governing equations of the elastic fluid are re-derived in the Eulerian frame by replacing the partial time derivatives by the properly invariant (frame indifferent) time rates. The `Maxwell from' of the frame indifferent formulation gives the frame indifferent system that is to replace the Maxwell system. This new system comprises terms already present in the classical Maxwell equations, alongside terms that are the progenitors of the Biot--Savart, Oersted--Ampere's, and Lorentz--force laws. Thus a frame indifferent (truly covariant) formulation of electromagnetism is achieved from a single postulate that the electromagnetic field is a kind of elastic (partly liquid partly solid) continuum.Comment: accepte

Southern Ocean biogenic blooms freezing-in Oligocene colder climates

AbstractCrossing a key atmospheric CO2 threshold triggered a fundamental global climate reorganisation ~34 million years ago (Ma) establishing permanent Antarctic ice sheets. Curiously, a more dramatic CO2 decline (~800–400 ppm by the Early Oligocene(~27 Ma)), postdates initial ice sheet expansion but the mechanisms driving this later, rapid drop in atmospheric carbon during the early Oligocene remains elusive and controversial. Here we use marine seismic reflection and borehole data to reveal an unprecedented accumulation of early Oligocene strata (up to 2.2 km thick over 1500 × 500 km) with a major biogenic component in the Australian Southern Ocean. High-resolution ocean simulations demonstrate that a tectonically-driven, one-off reorganisation of ocean currents, caused a unique period where current instability coincided with high nutrient input from the Antarctic continent. This unrepeated and short-lived environment favoured extreme bioproductivity and enhanced sediment burial. The size and rapid accumulation of this sediment package potentially holds ~1.067 × 1015 kg of the ‘missing carbon’ sequestered during the decline from an Eocene high CO2-world to a mid-Oligocene medium CO2-world, highlighting the exceptional role of the Southern Ocean in modulating long-term climate.</jats:p

Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI

Cerebral Autoregulation (CA), defined as the ability of the cerebral vasculature to maintain stable levels of blood flow despite changes in systemic blood pressure, is a critical factor in neurophysiological health. Magnetic resonance imaging (MRI) is a powerful technique for investigating cerebrovascular function, offering high spatial resolution and wide fields of view (FOV), yet it is relatively underutilized as a tool for assessment of CA. The aim of this study was to demonstrate the potential of using MRI to measure changes in cerebrovascular resistance in response to lower body negative pressure (LBNP). A Pulsed Arterial Spin Labeling (PASL) approach with short inversion times (TI) was used to estimate cerebral arterial blood volume (CBVa) in eight healthy subjects at baseline and -40mmHg LBNP. We estimated group mean CBVa values of 3.13±1.00 and 2.70±0.38 for baseline and lbnp respectively, which were the result of a differential change in CBVa during -40 mmHg LBNP that was dependent on baseline CBVa. These data suggest that the PASL CBVa estimates are sensitive to the complex cerebrovascular response that occurs during the moderate orthostatic challenge delivered by LBNP, which we speculatively propose may involve differential changes in vascular tone within different segments of the arterial vasculature. These novel data provide invaluable insight into the mechanisms that regulate perfusion of the brain, and establishes the use of MRI as a tool for studying CA in more detail