Renal Stone Risk During Space Flight: Assessment and Countermeasure Validation

NASA has focused its future on exploration class missions including the goal of returning to the moon and landing on Mars. With these objectives, humans will experience an extended exposure to the harsh environment of microgravity and the associated negative effects on all the physiological systems of the body. Exposure to microgravity affects human physiology and results in changes to the urinary chemical composition during and after space flight. These changes are associated with an increased risk of renal stone formation. The development of a renal stone would have health consequences for the crewmember and negatively impact the success of the mission. As of January 2007, 15 known symptomatic medical events consistent with urinary calculi have been experienced by 13 U.S. astronauts and Russian cosmonauts. Previous results from both MIR and Shuttle missions have demonstrated an increased risk for renal stone formation. These data have shown decreased urine volume, urinary pH and citrate levels and increased urinary calcium. Citrate, an important urinary inhibitor of calcium-containing renal stones binds with calcium in the urine, thereby reducing the amount of calcium available to form calcium oxalate stones. Urinary citrate also prevents calcium oxalate crystals from aggregating into larger crystals and into renal stones. In addition, citrate makes the urine less acidic which inhibits the development of uric acid stones. Potassium citrate supplementation has been successfully used to treat patients who have formed renal stones. The evaluation of potassium citrate as a countermeasure has been performed during the ISS Expeditions 3-6, 8, 11-13 and is currently in progress during the ISS Expedition 14 mission. Together with the assessment of stone risk and the evaluation of a countermeasure, this investigation provides an educational opportunity to all crewmembers. Individual urinary biochemical profiles are generated and the risk of stone formation is estimated. Increasing fluid intake is recommended to all crewmembers. These results can be used to lower the risk for stone formation through lifestyle, diet changes or therapeutic administration to minimize the risk for stone development. With human presence in microgravity a continuing presence and exploration class missions being planned, maintaining the health and welfare of all crewmembers is critical to the exploration of space

Mapping Planetary Volcanic Deposits: Identifying Vents and Distingushing between Effects of Eruption Conditions and Local Lava Storage and Release on Flow Field Morphology

Terrestrial geologic mapping techniques are regularly used for "photogeologic" mapping of other planets, but these approaches are complicated by the diverse type, areal coverage, and spatial resolution of available data sets. When available, spatially-limited in-situ human and/or robotic surface observations can sometimes introduce a level of detail that is difficult to integrate with regional or global interpretations. To assess best practices for utilizing observations acquired from orbit and on the surface, our team conducted a comparative study of geologic mapping and interpretation techniques. We compared maps generated for the same area in the San Francisco Volcanic Field (SFVF) in northern Arizona using 1) data collected for reconnaissance before and during the 2010 Desert Research And Technology Studies campaign, and 2) during a traditional, terrestrial field geology study. The operations, related results, and direct mapping comparisons are discussed in companion LPSC abstracts [1-3]. Here we present new geologic interpretations for a volcanic cone and related lava flows as derived from all approaches involved in this study. Mapping results indicate a need for caution when interpreting past eruption conditions on other planetary surfaces from orbital data alone

Comparing and Reconciling Traditional Field and Photogeologic Mapping Techniques: Lessons from the San Francisco Volcanic Field, Arizona

Cartographic products and - specifically - geologic maps provide critical assistance for establishing physical and temporal frameworks of planetary surfaces. The technical methods that result in the creation of geologic maps vary depending on how observations are made as well as the overall intent of the final products [1-3]. These methods tend to follow a common linear work flow, including the identification and delineation of spatially and temporally discrete materials (units), the documentation of their primary (emplacement) and secondary (erosional) characteristics, analysis of the relative and absolute age relationships between these materials, and the collation of observations and interpretations into an objective map product. The "objectivity" of a map is critical cross comparison with overlapping maps and topical studies as well as its relevance to scientific posterity. However, the "accuracy" and "correctness" of a geologic map is very subject to debate. This can be evidenced by comparison of existing geologic maps at various scales, particularly those compiled through field- and remote-based mapped efforts. Our study focuses on comparing the fidelity of (1) "Apollo-style" geologic investigations, where typically non-geologist crew members follow static traverse routes established through pre-mission planning, and (2) "traditional" field-based investigations, where geologists are given free rein to observe without preplanned routes. This abstract summarizes the regional geology wherein our study was conducted, presents the geologic map created from traditional field mapping techniques, and offers basic insights into how geologic maps created from different tactics can be reconciled in support of exploratory missions. Additional abstracts [4-6] from this study discuss various exploration and science results of these efforts

Sports mega-events – three sites of contemporary political contestation

This article discusses the contemporary politics of sports mega-events, involving the Olympic Games and Fédération Internationale de Football Association (FIFA) Men’s Football World Cup Finals as well as other lower ‘order’ sports megas, taking two main forms: the promotional and the protest. There is a politics in, and a politics of, sports mega-events. The former focuses on the internal politics of the organizing bodies, such as the International Olympic Committee and FIFA. This form of politics has been written about elsewhere, and hence, there is no detailed discussion in this article about it. Instead this article offers a brief discussion of the range and number of sports mega-events since 2000, an assessment of the contemporary politics of sports mega-events, a focus on three main sites of political contestation – rights, legacy and labour, and finally, it offers conclusions about research into the politics of sports mega-events

Mapping Planetary Volcanic Deposits: Identifying Vents and Distinguishing between Effects of Eruption Conditions and Local Storage and Release on Flow Field Morphology

Terrestrial geologic mapping techniques are regularly used for "photogeologic" mapping of other planets, but these approaches are complicated by the diverse type, areal coverage, and spatial resolution of available data sets. When available, spatially-limited in-situ human and/or robotic surface observations can sometimes introduce a level of detail that is difficult to integrate with regional or global interpretations. To assess best practices for utilizing observations acquired from orbit and on the surface, our team conducted a comparative study of geologic mapping and interpretation techniques. We compared maps generated for the same area in the San Francisco Volcanic Field (SFVF) in northern Arizona using 1) data collected for reconnaissance before and during the 2010 Desert Research And Technology Studies campaign, and 2) during a traditional, terrestrial field geology study. The operations, related results, and direct mapping comparisons are discussed in companion LPSC abstracts. Here we present new geologic interpretations for a volcanic cone and related lava flows as derived from all approaches involved in this study. Mapping results indicate a need for caution when interpreting past eruption conditions on other planetary surfaces from orbital data alone

Cardiac and Vascular Responses to Thigh Cuffs and Respiratory Maneuvers on Crewmembers of the International Space Station

The transition to microgravity eliminates the hydrostatic gradients in the vascular system. The resulting fluid redistribution commonly manifests as facial edema, engorgement of the external neck veins, and a decrease in leg diameter. This experiment examined the responses to modified Valsalva and Mueller maneuvers measured by cardiac and vascular ultrasound (ECHO) in a baseline steady state and during preload reduction introduced with thigh occlusion cuffs used as a counter-measure device (Braslet cuffs) measured by cardiac and vascular ultrasound examinations. Methods: Nine International Space Station crewmember subjects (Expeditions 16 - 20) were examined in 15 experiment sessions 101 +/- 46.days after launch (mean +/- SD; 33 - 185). Twenty Seven cardiac and vascular parameters were obtained with/without respiratory maneuvers before and after tightening of the Braslet cuffs. Results: Non-physicians performed diagnostic-quality cardiac and vascular ultrasound examinations using remote guidance. Three of 27 combinations of maneuvers and Braslet or Braslet alone were identified as being significant changed when compared to baseline. Eleven of 81 differences between combinations of Mueller, Valsalva or baseline were significant and related to cardiac preload reduction or increase in lower extremity venous volume. Conclusions: Acute application of Braslet occlusion cuffs causes lower extremity fluid sequestration and exerts commensurate measurable effects on cardiac performance in microgravity. Ultrasound techniques to measure the hemodynamic effects of thigh cuffs in combination with respiratory maneuvers may serve as an invaluable tool in determining the volume status of the cardiac patient at the 'microgravity bedside'

Designs Studies of Low-Aspect Ratio Quasi-Omnigenous Stellarators

Significant progress has been made in the development of new modest-size compact stellarator devices that could test optimization principles for the design of a more attractive reactor. These are 3 and 4 field period low-aspect-ratio quasi-omnigenous (QO) stellarators based on an optimization method that targets improved confinement, stability, ease of coil design, low-aspect-ratio, and low bootstrap current

Substitutional Reality System: A Novel Experimental Platform for Experiencing Alternative Reality

We have developed a novel experimental platform, referred to as a substitutional reality (SR) system, for studying the conviction of the perception of live reality and related metacognitive functions. The SR system was designed to manipulate people's reality by allowing them to experience live scenes (in which they were physically present) and recorded scenes (which were recorded and edited in advance) in an alternating manner without noticing a reality gap. All of the naïve participants (n = 21) successfully believed that they had experienced live scenes when recorded scenes had been presented. Additional psychophysical experiments suggest the depth of visual objects does not affect the perceptual discriminability between scenes, and the scene switch during head movement enhance substitutional performance. The SR system, with its reality manipulation, is a novel and affordable method for studying metacognitive functions and psychiatric disorders