Wanderl[o]st: Lost Identities and Losing Place in the New World (Dis)Order

Through the investigation of works by contemporary Spanish and Spanish-American writers--Roberto Bolaño, Abilio Estévez, Lucía Etxebarria, Ray Loriga, and Antonio José Ponte--this project explores subjects that get lost due to shifts toward totalizing economic and/or political systems. Through close textual analysis, it examines who these lost subjects are, why they get lost, and what the ramifications of being lost are for their respective societies and the world at large. The time period that the plots of these works cover (1968 to present) is one marked by socio-economic shifts, responsible for spurring the alienation of the subjects of these texts. In Chile, Pinochet's coup shattered ideals for a new generation; in Cuba, the collapse of the Soviet Union left the island isolated; while in Spain, Spaniards come to grips with the disturbing memories of schism provoked by the Civil War and isolation induced by the dictatorship of Francisco Franco

Line graphs as social networks

The line graphs are clustered and assortative. They share these topological features with some social networks. We argue that this similarity reveals the cliquey character of the social networks. In the model proposed here, a social network is the line graph of an initial network of families, communities, interest groups, school classes and small companies. These groups play the role of nodes, and individuals are represented by links between these nodes. The picture is supported by the data on the LiveJournal network of about 8 x 10^6 people. In particular, sharp maxima of the observed data of the degree dependence of the clustering coefficient C(k) are associated with cliques in the social network.Comment: 11 pages, 4 figure

VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis

Clinical sequencing efforts are rapidly identifying sarcoma gene fusions that lack functional validation. An example is the fusion of transcriptional coactivators, VGLL2-NCOA2, found in infantile rhabdomyosarcoma. To delineate VGLL2-NCOA2 tumorigenic mechanisms and identify therapeutic vulnerabilities, we implement a cross-species comparative oncology approach with zebrafish, mouse allograft, and patient samples. We find that VGLL2-NCOA2 is sufficient to generate mesenchymal tumors that display features of immature skeletal muscle and recapitulate the human disease. A subset of VGLL2-NCOA2 zebrafish tumors transcriptionally cluster with embryonic somitogenesis and identify VGLL2-NCOA2 developmental programs, including a RAS family GTPase, ARF6. In VGLL2-NCOA2 zebrafish, mouse, and patient tumors, ARF6 is highly expressed. ARF6 knockout suppresses VGLL2-NCOA2 oncogenic activity in cell culture, and, more broadly, ARF6 is overexpressed in adult and pediatric sarcomas. Our data indicate that VGLL2-NCOA2 is an oncogene that leverages developmental programs for tumorigenesis and that reactivation or persistence of ARF6 could represent a therapeutic opportunity

Restored Agricultural Wetlands in central Iowa: Habitat Quality and Amphibian Response

Amphibians are declining throughout the United States and worldwide due, partly, to habitat loss. Conservation practices on the landscape restore wetlands to denitrify tile drainage effluent and restore ecosystem services. Understanding how water quality, hydroperiod, predation, and disease affect amphibians in restored wetlands is central to maintaining healthy amphibian populations in the region. We examined the quality of amphibian habitat in restored wetlands relative to reference wetlands by comparing species richness, developmental stress, and adult leopard frog (Lithobates pipiens) survival probabilities to a suite of environmental metrics. Although measured habitat variables differed between restored and reference wetlands, differences appeared to have sub-lethal rather than lethal effects on resident amphibian populations. There were few differences in amphibian species richness and no difference in estimated survival probabilities between wetland types. Restored wetlands had more nitrate and alkaline pH, longer hydroperiods, and were deeper, whereas reference wetlands had more amphibian chytrid fungus zoospores in water samples and resident amphibians exhibited increased developmental stress. Restored and reference wetlands are both important components of the landscape in central Iowa and maintaining a complex of fish-free wetlands with a variety of hydroperiods will likely contribute to the persistence of amphibians in this landscape