A constraint on a varying proton--electron mass ratio 1.5 billion years after the Big Bang

A molecular hydrogen absorber at a lookback time of 12.4 billion years, corresponding to 10$\%$ of the age of the universe today, is analyzed to put a constraint on a varying proton--electron mass ratio, $\mu$. A high resolution spectrum of the J1443$+$2724 quasar, which was observed with the Very Large Telescope, is used to create an accurate model of 89 Lyman and Werner band transitions whose relative frequencies are sensitive to $\mu$, yielding a limit on the relative deviation from the current laboratory value of $\Delta\mu/\mu=(-9.5\pm5.4_{\textrm{stat}} \pm 5.3_{\textrm{sys}})\times 10^{-6}$.Comment: Accepted for publication in PRL. Includes supplemental materia

The UVES Large Program for testing fundamental physics - III. Constraints on the fine-structure constant from 3 telescopes

Large statistical samples of quasar spectra have previously indicated possible cosmological variations in the fine-structure constant, $\alpha$. A smaller sample of higher signal-to-noise ratio spectra, with dedicated calibration, would allow a detailed test of this evidence. Towards that end, we observed equatorial quasar HS 1549$+$1919 with three telescopes: the Very Large Telescope, Keck and, for the first time in such analyses, Subaru. By directly comparing these spectra to each other, and by `supercalibrating' them using asteroid and iodine-cell tests, we detected and removed long-range distortions of the quasar spectra's wavelength scales which would have caused significant systematic errors in our $\alpha$ measurements. For each telescope we measure the relative deviation in $\alpha$ from the current laboratory value, $\Delta\alpha/\alpha$, in 3 absorption systems at redshifts $z_{\mathrm{abs}}=1.143$, 1.342, and 1.802. The nine measurements of $\Delta\alpha/\alpha$ are all consistent with zero at the 2-$\sigma$ level, with 1-$\sigma$ statistical (systematic) uncertainties 5.6--24 (1.8--7.0) parts per million (ppm). They are also consistent with each other at the 1-$\sigma$ level, allowing us to form a combined value for each telescope and, finally, a single value for this line of sight: $\Delta\alpha/\alpha=-5.4 \pm 3.3_{\mathrm{stat}} \pm 1.5_{\mathrm{sys}}$ ppm, consistent with both zero and previous, large samples. We also average all Large Programme results measuring $\Delta\alpha/\alpha=-0.6 \pm 1.9_{\mathrm{stat}} \pm 0.9_{\mathrm{sys}}$ ppm. Our results demonstrate the robustness and reliability at the 3 ppm level afforded by supercalibration techniques and direct comparison of spectra from different telescopes.Comment: 24 pages, 11 figures, 9 table

Is it possible to increase the sustainability of arable and ruminant agriculture by reducing inputs?

Until recently, agricultural production was optimised almost exclusively for profit but now farming is under pressure to meet environmental targets. A method is presented and applied for optimising the sustainability of agricultural production systems in terms of both economics and the environment. Components of the agricultural production chain are analysed using environmental life-cycle assessment (LCA) and a financial value attributed to the resources consumed and burden imposed on the environment by agriculture, as well as to the products. The sum of the outputs is weighed against the inputs and the system considered sustainable if the value of the outputs exceeds those of the inputs. If this ratio is plotted against the sum of inputs for all levels of input, a diminishing returns curve should result and the optimum level of sustainability is located at the maximum of the curve. Data were taken from standard economic almanacs and from published LCA reports on the extent of consumption and environmental burdens resulting from farming in the UK. Land-use is valued using the concept of ecosystem services. Our analysis suggests that agricultural systems are sustainable at rates of production close to current levels practiced in the UK. Extensification of farming, which is thought to favour non-food ecosystem services, requires more land to produce the same amount of food. The loss of ecosystem services hitherto provided by natural land brought into production is greater than that which can be provided by land now under extensive farming. This loss of ecosystem service is large in comparison to the benefit of a reduction in emission of nutrients and pesticides. However, food production is essential, so the coupling of subsidies that represent a relatively large component of the economic output in EU farming, with measures to reduce pollution are well-aimed. Measures to ensure that as little extra land is brought into production as possible or that marginal land is allowed to revert to nature would seem to be equally well-aimed, even if this required more intensive use of productive areas. We conclude that current arable farming in the EU is sustainable with either realistic prices for products or some degree of subsidy and that productivity per unit area of land and greenhouse gas emission (subsuming primary energy consumption) are the most important pressures on the sustainability of farming

Mannose binding lectin is required for alphavirus-induced arthritis/myositis

Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within the muscle and joints, and prior studies have demonstrated that the host complement system contributes to development of disease. In this study, we have used a mouse model of RRV-induced disease to identify and characterize which complement activation pathways mediate disease progression after infection, and we have identified the mannose binding lectin (MBL) pathway, but not the classical or alternative complement activation pathways, as essential for development of RRV-induced disease. MBL deposition was enhanced in RRV infected muscle tissue from wild type mice and RRV infected MBL deficient mice exhibited reduced disease, tissue damage, and complement deposition compared to wild-type mice. In contrast, mice deficient for key components of the classical or alternative complement activation pathways still developed severe RRV-induced disease. Further characterization of MBL deficient mice demonstrated that similar to C3(-/-) mice, viral replication and inflammatory cell recruitment were equivalent to wild type animals, suggesting that RRV-mediated induction of complement dependent immune pathology is largely MBL dependent. Consistent with these findings, human patients diagnosed with RRV disease had elevated serum MBL levels compared to healthy controls, and MBL levels in the serum and synovial fluid correlated with severity of disease. These findings demonstrate a role for MBL in promoting RRV-induced disease in both mice and humans and suggest that the MBL pathway of complement activation may be an effective target for therapeutic intervention for humans suffering from RRV-induced arthritis and myositis.This work was supported by NIH/NIAMS R01 AR 047190 awarded to MTH

Hubble Space Telescope Images of Stephan's Quintet: Star Cluster Formation in a Compact Group Environment

Analysis of Hubble Space Telescope/Wide Field Planetary Camera 2 images of Stephan's Quintet, Hickson Compact Group 92, yielded 115 candidate star clusters (with V-I < 1.5). Unlike in merger remants, the cluster candidates in Stephan's Quintet are not clustered in the inner regions of the galaxies; they are spread over the debris and surrounding area. Specifically, these sources are located in the long sweeping tail and spiral arms of NGC 7319, in the tidal debris of NGC 7318B/A, and in the intragroup starburst region north of these galaxies. Analysis of the colors of the clusters indicates several distinct epochs of star formation that appear to trace the complex history of dynamical interactions in this compact group.Comment: 24 pages, 21 figures (13 PostScript and 8 JPEG), LaTeX (uses aastexug.sty), accepted for publication in the Astronomical Journal (July 2001). Full-resolution PostScript figures available at http://www.astro.psu.edu/users/gallsc/sq/figs.tar.g

Star cluster survival and compressive tides in Antennae-like mergers

Gravitational tides are widely understood to strip and destroy galactic substructures. In the course of a galaxy merger, however, transient totally compressive tides may develop and prevent star forming regions from dissolving, after they condensed to form clusters of stars. We study the statistics of such compressive modes in an N-body model of the galaxy merger NGC 4038/39 (the Antennae) and show that ~15% of the disc material undergoes compressive tides at pericentre. The spatial distribution of observed young clusters in the overlap and nuclear regions of the Antennae matches surprisingly well the location of compressive tides obtained from simulation data. Furthermore, the statistics of time intervals spent by individual particles embedded in a compressive tide yields a log-normal distribution of characteristic time ~10 Myr, comparable to star cluster formation timescales. We argue that this generic process is operative in galaxy mergers at all redshifts and possibly enhances the formation of star clusters. We show with a model calculation that this process will prevent the dissolution of a star cluster during the formation phase, even for a star formation efficiency as low as ~10%. The transient nature of compressive tides implies that clusters may dissolve rapidly once the tidal field switches to the usual disruptive mode.Comment: 5 pages, 3 figures, accepted for publication in MNRAS Letters. For higher resolution, see http://astro.u-strasbg.fr/~renaud/publi/mnras08.pd

Imaging in Radiation Oncology: A Perspective

This paper reviews the integration of imaging and radiation oncology, and discusses challenges and opportunities for improving the practice of radiation oncology with imaging

Myd88-Dependent Toll-Like Receptor 7 Signaling Mediates Protection from Severe Ross River Virus-Induced Disease in Mice

Arthralgia-associated alphaviruses, including chikungunya virus (CHIKV) and Ross River virus (RRV), pose significant public health threats because of their ability to cause explosive outbreaks of debilitating arthralgia and myalgia in human populations. Although the host inflammatory response is known to contribute to the pathogenesis of alphavirus-induced arthritis and myositis, the role that Toll-like receptors (TLRs), which are major regulators of host antiviral and inflammatory responses, play in the pathogenesis of alphavirus-induced arthritis and myositis has not been extensively studied. Using a mouse model of RRV-induced myositis/arthritis, we found that myeloid differentiation primary response gene 88 (Myd88)-dependent TLR7 signaling is involved in protection from severe RRV-associated disease. Infections of Myd88- and TLR7-deficient mouse strains with RRV revealed that both Myd88 and TLR7 significantly contributed to protection from RRV-induced mortality, and both mouse strains exhibited more severe tissue damage than wild-type (WT) mice following RRV infection. While viral loads were unchanged in either Myd88 or TLR7 knockout mice compared to WT mice at early times postinfection, both Myd88 and TLR7 knockout mice exhibited higher viral loads than WT mice at late times postinfection. Furthermore, while high levels of RRV-specific antibody were produced in TLR7-deficient mice, this antibody had very little neutralizing activity and had lower affinity than WT antibody. Additionally, TLR7- and Myd88-deficient mice showed defects in germinal center activity, suggesting that TLR7-dependent signaling is critical for the development of protective antibody responses against RRV