Production methods and controls in the shoe manufacturing industry.

Typescript. Thesis (S.T.B.)--Boston University Includes bibliographical references

Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia

Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in human myocardial tissue at defined survival times following cardiac arrest and determined alterations in expression following ischaemia. In the normal human heart, GADD34 immunoreactivity was generally intense and present within most cells. GADD34 immunoreactivity was downregulated in tissue displaying ischaemic damage and remained intense in adjacent non-infarcted tissue. Unlike brain, GADD34 was not found to be upregulated in the peri-infarct zone. Cells displaying apoptotic changes were located in regions displaying reduced GADD34 immunoreactivity. In the brain, it is thought that GADD34 supports re-initiation of protein synthesis following ischaemia. Similarly, GADD34 may perform important functions in cardiac tissue in response to ischaemia

Determining Recent Sedimentation Rates of the Lavaca-Navidad River System, Texas

Replacement of wetlands by water and barren flats in the lower alluvial valley and delta of the Lavaca River suggests that relative sea-level rise and possible reductions in sediment supply have rendered the Lavaca-Navidad fluvial-deltaic system incapable of maintaining sufficient elevation to prevent its submergence. The Lavaca-Navidad River System transports a significant load of suspended sediment (Longley, 1992a) and therefore should have the potential for delivering enough sediment to offset subsidence and submergence.Bureau of Economic Geolog

Shoreline Types of the Central Texas Coast: Matagorda to Corpus Christi Areas

The report details how the Bureau of Economic Geology (BEG) classified and mapped the shores of the central Texas coast, offering definitions of each shoreline type and providing examples that demonstrate how the physical attributes of shoreline habitats influence the impact of spilled oil. This information is crucial for the creation of Environmental Sensitivity Index (ESI) maps used in oil spill response and contingency planning. Shorelines were classified according to an ESI scheme established by Research Planning, Inc. (RPI) and the BEG, with rankings ranging from 1 to 10. Examples of each shoreline type are provided, along with explanations of common occurrences of multiple adjacent shoreline types. Mapping of shoreline types was conducted on U.S.G.S. topographic quadrangles (1:24,000) using recent vertical aerial photographs, low-altitude color video surveys from 1997, oblique color slides from 1992, and previous field experience. Ground spot checks were performed in May 1998 to verify the accuracy of the maps. The Matagorda to Corpus Christi region was chosen for the second phase of ESI mapping in Texas due to its diverse shoreline types, dense industrialization, environmentally sensitive wetlands, and significant volume of oil transportation through major shipping channels and the Intracoastal Waterway in the region.Bureau of Economic Geolog

Determining Recent Sedimentation Rates of the Trinity River, Texas

Replacement of wetlands by water and flats in the lower alluvial valley and delta of the Trinity River suggests that relative sea-level rise and reductions in sediment supply have rendered the fluvial-deltaic system incapable of maintaining sufficient elevation to prevent its submergence. The Trinity River transports the greatest load of suspended sediment of all rivers emptying into Texas bays (Longley, 1992a), and therefore, it has the greatest potential for delivering enough sediment to offset subsidence.Bureau of Economic Geolog

Shoreline Types of the Upper Texas Coast: Sabine-Galveston-Freeport-Sargent Areas

The following report describes how the Bureau of Economic Geology (BEG) classified and mapped the shores of the upper Texas coast for the Texas Natural Resources Inventory (NRI) Program, provides definitions of each shoreline type, and presents examples that illustrate how physical attributes of the shoreline habitats control the impact of spilled oil. This information is an integral part of the Environmental Sensitivity Index (ESI) maps used for oil spill response and contingency planning. Shorelines were classified according to an ESI scheme established by Research Planning, Inc. (RPI) and the BEG. The ESI rankings (1-10) are described, examples of each type are illustrated, and the common occurrences of multiple adjacent shoreline types are given. Shoreline types were mapped on U.S.G.S. topographic quadrangles (1:24,000) using recent vertical aerial photographs, low-altitude color video surveys taken in 1992, oblique color slides taken in 1992 and 1994, an overflight in 1994, and previous field experience. All the maps were field checked in June 1994 from the air and some sites were checked on the ground. The Sabine to Sargent region was selected for the initial phase of ESI mapping in Texas because shore types there are diverse, it is densely industrialized, extant wetlands are environmentally sensitive, and a large volume of oil is transported through major shipping channels and the Intracoastal Waterway of the region.Bureau of Economic Geolog

East Texas and Western Louisiana Coastal Erosion Study

The following brief report summarizes the major accomplishments achieved during the first year of study of coastal erosion and wetlands loss along the southeastern Texas coast.Bureau of Economic Geolog

Dietary intakes in adult patients with cystic fibrosis–do they achieve guidelines?

AbstractBackground: Most patients with cystic fibrosis (CF) require a higher energy and protein intake than their healthy peer group. There are few data on dietary intakes of adult patients. The aim of this study was to determine nutritional intakes in an adult population with CF. The impact of nutritional intervention and disease on macronutrient intake was examined. Methods: Retrospective cross-sectional analysis of 94 unweighed food diaries at annual review (1995–2000). Energy and protein intakes were compared to the estimated average requirement (EAR) for energy and reference nutrient intake (RNI) for protein. The effect of diet alone, oral supplements, enteral tube feeding, and cystic fibrosis related diabetes (CFRD), on macronutrient intake was examined and impact of pancreatic sufficency (PS) and lung transplantation. Results: Mean energy and protein intakes approached recommended CF guidelines, but in 72% of assessments these values were not achieved. Mean energy and protein intakes for patients on diet alone and protein intake for those with CFRD failed to meet recommendations. Oral supplementation and enteral tube feeding regimens increased energy and protein intake above recommended levels. No group achieved 40% total energy from fat. Patients receiving enteral tube feeds had the highest mean energy and protein intakes but lowest body mass index (BMI) and lung function. Conclusion: Adequate mean energy and protein intakes in adult patients with CF mask subgroups of patients who fail to meet recommendations ie. diet alone, diabetic. Oral supplementation and enteral tube feeding increase energy and protein intake but fail to achieve an adequate BMI level in subjects with a decreased clinical status. Individual nutritional assessment remains essential

RNA polymerase III transcription is repressed in response to the tumour suppressor ARF

The tumour suppressor protein ARF provides a defence mechanism against hyperproliferative stresses that can result from the aberrant activation of oncogenes. Accordingly, ARF is silenced or deleted in many human cancers. Activation of ARF can arrest growth and cell cycle progression, or trigger apoptosis. A principle mediator of these effects is p53, which ARF stabilizes by binding and inhibiting MDM2. However, ARF has additional targets and remains able to block growth in the absence of p53, albeit less efficiently. For example, ARF can suppress rRNA production in a p53-independent manner. We have found that the synthesis of tRNA by RNA polymerase III is also inhibited in response to ARF. However, in contrast to its effects on rRNA synthesis, ARF is unable to inhibit tRNA gene transcription when p53 is ablated. These results add to the growing list of cellular changes that can be triggered by ARF induction