Monitoring environmental cleanliness on two surgical wards

Ten hand-touch sites were screened weekly on two surgical wards over two consecutive six-month periods. The results were analysed using hygiene standards, which specify 1) an aerobic colony count (ACC) >2.5cfu/cm2, and 2) presence of coagulase-positive staphylococci, as hygiene failures. Sites most often failing the standards were beds and hoist (64%: 33 of 52 weeks), bedside lockers (62%: 32 of 52) and overbed tables (44%: 23 of 52). Methicillin-susceptible/resistant Staphylococcus aureus (MSSA/MRSA) were more often recovered from lockers, overbed tables and beds. Recovery of MSSA/MRSA at any site was significantly associated with an ACC>2.5cfu/cm2 from that site (p=0.001; OR: 3.35 (95% CI 1.79, 6.28)). In addition, total ACC's>2.5cfu/cm2 each week were significantly associated with weekly bed occupancies >95% (p=0.0004; OR: 2.94 (95% CI 1.44, 6.02)). Higher microbial growth levels from hand-touch sites reflect weekly bed occupancies and indicate a risk for both resistant and susceptible S.aureus. These organisms are more likely to be recovered from near-patient sites on the ward

The Sachs-Wolfe Effect: Gauge Independence and a General Expression

In this paper we address two points concerning the Sachs-Wolfe effect: (i) the gauge independence of the observable temperature anisotropy, and (ii) a gauge-invariant expression of the effect considering the most general situation of hydrodynamic perturbations. The first result follows because the gauge transformation of the temperature fluctuation at the observation event only contributes to the isotropic temperature change which, in practice, is absorbed into the definition of the background temperature. Thus, we proceed without fixing the gauge condition, and express the Sachs-Wolfe effect using the gauge-invariant variables.Comment: 5 pages, closer to published versio

Suppression of static stripe formation by next-neighbor hopping

We show from real-space Hartree-Fock calculations within the extended Hubbard model that next-nearest neighbor (t') hopping processes act to suppress the formation of static charge stripes. This result is confirmed by investigating the evolution of charge-inhomogeneous corral and stripe phases with increasing t' of both signs. We propose that large t' values in YBCO prevent static stripe formation, while anomalously small t' in LSCO provides an additional reason for the appearance of static stripes only in these systems.Comment: 4 pages, 5 figure

The Primordial Gravitational Wave Background in String Cosmology

We find the spectrum P(w)dw of the gravitational wave background produced in the early universe in string theory. We work in the framework of String Driven Cosmology, whose scale factors are computed with the low-energy effective string equations as well as selfconsistent solutions of General Relativity with a gas of strings as source. The scale factor evolution is described by an early string driven inflationary stage with an instantaneous transition to a radiation dominated stage and successive matter dominated stage. This is an expanding string cosmology always running on positive proper cosmic time. A careful treatment of the scale factor evolution and involved transitions is made. A full prediction on the power spectrum of gravitational waves without any free-parameters is given. We study and show explicitly the effect of the dilaton field, characteristic to this kind of cosmologies. We compute the spectrum for the same evolution description with three differents approachs. Some features of gravitational wave spectra, as peaks and asymptotic behaviours, are found direct consequences of the dilaton involved and not only of the scale factor evolution. A comparative analysis of different treatments, solutions and compatibility with observational bounds or detection perspectives is made.Comment: LaTeX, 50 pages with 2 figures. Uses epsfig and psfra

CBR Anisotropy from Primordial Gravitational Waves in Two-Component Inflationary Cosmology

We examine stochastic temperature fluctuations of the cosmic background radiation (CBR) arising via the Sachs-Wolfe effect from gravitational wave perturbations produced in the early universe. We consider spatially flat, perturbed FRW models that begin with an inflationary phase, followed by a mixed phase containing both radiation and dust. The scale factor during the mixed phase takes the form $a(\eta)=c_1\eta^2+c_2\eta+c_3$, where $c_i$ are constants. During the mixed phase the universe smoothly transforms from being radiation to dust dominated. We find analytic expressions for the graviton mode function during the mixed phase in terms of spheroidal wave functions. This mode function is used to find an analytic expression for the multipole moments $\langle a_l^2\rangle$ of the two-point angular correlation function $C(\gamma)$ for the CBR anisotropy. The analytic expression for the multipole moments is written in terms of two integrals, which are evaluated numerically. The results are compared to multipoles calculated for models that are {\it completely} dust dominated at last-scattering. We find that the multipoles $\langle a_l^2\rangle$ of the CBR temperature perturbations for $l>10$ are significantly larger for a universe that contains both radiation and dust at last-scattering. We compare our results with recent, similar numerical work and find good agreement. The spheroidal wave functions may have applications to other problems of cosmological interest.Comment: 28 pgs + 6 postscript figures, RevTe

Pairing Correlations in a Generalized Hubbard Model for the Cuprates

Using numerical diagonalization of a 4x4 cluster, we calculate on-site s, extended s and d pairing correlation functions (PCF) in an effective generalized Hubbard model for the cuprates, with nearest-neighbor correlated hopping and next nearest-neighbor hopping t'. The vertex contributions (VC) to the PCF are significantly enhanced, relative to the t-t'-U model. The behavior of the PCF and their VC, and signatures of anomalous flux quantization, indicate superconductivity in the d-wave channel for moderate doping and in the s-wave channel for high doping and small U.Comment: 5 pages, 5 figure

Limits on the gravity wave contribution to microwave anisotropies

We present limits on the fraction of large angle microwave anisotropies which could come from tensor perturbations. We use the COBE results as well as smaller scale CMB observations, measurements of galaxy correlations, abundances of galaxy clusters, and Lyman alpha absorption cloud statistics. Our aim is to provide conservative limits on the tensor-to-scalar ratio for standard inflationary models. For power-law inflation, for example, we find T/S<0.52 at 95% confidence, with a similar constraint for phi^p potentials. However, for models with tensor amplitude unrelated to the scalar spectral index it is still currently possible to have T/S>1.Comment: 23 pages, 7 figures, accepted for publication in Phys. Rev. D. Calculations extended to blue spectral index, Fig. 6 added, discussion of results expande

Conformations of closed DNA

We examine the conformations of a model for a short segment of closed DNA. The molecule is represented as a cylindrically symmetric elastic rod with a constraint corresponding to a specification of the linking number. We obtain analytic expressions leading to the spatial configuration of a family of solutions representing distortions that interpolate between the circular form of DNA and a figure-eight form that represents the onset of interwinding. We are also able to generate knotted loops. We suggest ways to use our approach to produce other configurations relevant to studies of DNA structure. The stability of the distorted configurations is assessed, along with the effects of fluctuations on the free energy of the various configurations.Comment: 39 pages in REVTEX with 14 eps figures. Submitted to Phys. Rev. E. This manuscript updates, expands and revises, to a considerable extent, a previously posted manuscript, entitled "Conformations of Circular DNA," which appeared as cond-mat/970104

HOPX functions as a tumour suppressor in head and neck cancer.

Head and neck squamous cell carcinoma (HNSCC) is generalized term that encompasses a diverse group of cancers that includes tumours of the oral cavity (OSCC), oropharynx (OPSCC) and nasopharynx (NPC). Genetic alterations that are common to all HNSCC types are likely to be important for squamous carcinogenesis. In this study, we have investigated the role of the homeodomain-only homeobox gene, HOPX, in the pathogenesis of HNSCC. We show that HOPX mRNA levels are reduced in OSCC and NPC cell lines and tissues and there is a general reduction of HOPX protein expression in these tumours and OPSCCs. HOPX promoter methylation was observed in a subset of HNSCCs and was associated with a worse overall survival in HPV negative tumours. RNAseq analysis of OSCC cells transfected with HOPX revealed a widespread deregulation of the transcription of genes related to epithelial homeostasis and ectopic over-expression of HOPX in OSCC and NPC cells inhibited cell proliferation, plating efficiency and migration, and enhanced sensitivity to UVA-induced apoptosis. Our results demonstrate that HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis

Evidence against water delivery by impacts within 10 million years of planetesimal formation

The quenched (rapidly-cooled) angrite meteorites, which formed in the inner Solar System, record large-scale planetary mixing in the first few Ma of Solar System history, and therefore, provide a unique opportunity to investigate the role of impacts in terms of water addition to the growing planetesimals. Here we investigate the H isotopic composition and H2O abundance of relict olivine grains that survived impact melting within Asuka (A) 12,209 and compare them with impact melt-produced groundmass fractions using in-situ nanoscale secondary ion mass spectrometry (NanoSIMS). These analyses test if the angrite parent body (APB) acquired a CC-like H isotopic composition before early large-scale impact mixing and/or acquired volatiles by subsequent impact(s). Furthermore, we analyse the H isotopic composition and H2O abundance of later-forming plutonic (NWA 4801), intermediate (NWA 10,463) and dunitic (NWA 8535) angrite meteorites to assess the role of impacts, in terms of volatile delivery, during the first 50 Ma of the inner Solar System history. The H isotopic composition of most quenched angrites appears to be affected by degassing. Consequently, we opt to use the weighted average δD of pyroxenes and olivines in the plutonic angrite, NWA 4801, to estimate the original composition of the APB (-235 ± 113 ‰ 1σ, n = 18), in agreement with recent studies on the hydrogen isotopic signatures of mineral-hosted melt inclusions in D'Orbigny and Sahara 99,555. Additionally, we use the H2O abundances of NWA 4801 pyroxene (7.9 ± 1 µg/g 2σ) and olivine (6.1 ± 0.6 µg/g 2σ) to estimate the lower (85 to 110 µg/g) and upper (519 to 1089 µg/g) limits of the primitive APB mantle H2O content, implying that the APB was one of the most hydrated bodies in the early inner Solar System. The similarity of δD/H2O systematics in the relict olivine grains and groundmass olivine within A 12,209 argues against water delivery through impacts in the early inner Solar System. Overall, the non-carbonaceous reservoir in the inner Solar System appears to retain a single source of water, which isotopically resembles either water ice in carbonaceous chondrite parent bodies or fractionated nebula water