Are there socioeconomic gradients in stage and grade of breast cancer at diagnosis? Cross sectional analysis of UK cancer registry data

Socioeconomic gradients in uptake of breast cancer screening in the United Kingdom should, intuitively, lead to socioeconomic gradients in disease progression at diagnosis. However, studies have found little evidence of such an effect. Although this could be interpreted as evidence that socioeconomic gradients in uptake of screening do not have clinically important consequences, all of the published studies have used data from before (pre-1988) or during the early stages (1988-95) of implementation of the national breast cancer screening programme. We investigated the relation between socioeconomic position and progression of breast cancer at diagnosis by using recent data from the Northern and Yorkshire Cancer Registry and Information Service (NYCRIS), which is estimated to achieve around 93% ascertainment

Energetics of Domain Walls in the 2D t-J model

Using the density matrix renormalization group, we calculate the energy of a domain wall in the 2D t-J model as a function of the linear hole density \rho_\ell, as well as the interaction energy between walls, for J/t=0.35. Based on these results, we conclude that the ground state always has domain walls for dopings 0 < x < 0.3. For x < 0.125, the system has (1,0) domain walls with \rho_\ell ~ 0.5, while for 0.125 < x < 0.17, the system has a possibly phase-separated mixture of walls with \rho_\ell ~ 0.5 and \rho_\ell =1. For x > 0.17, there are only walls with \rho_\ell =1. For \rho_\ell = 1, diagonal (1,1) domain walls have very nearly the same energy as (1,0) domain walls.Comment: Several minor changes. Four pages, four encapsulated figure

Is Cosmology Solved?

We have fossil evidence from the thermal background radiation that our universe expanded from a considerably hotter denser state. We have a well defined and testable description of the expansion, the relativistic Friedmann-Lemaitre model. Its observational successes are impressive but I think hardly enough for a convincing scientific case. The lists of observational constraints and free hypotheses within the model have similar lengths. The scorecard on the search for concordant measures of the mass density parameter and the cosmological constant shows that the high density Einstein-de Sitter model is challenged, but that we cannot choose between low density models with and without a cosmological constant. That is, the relativistic model is not strongly overconstrained, the usual test of a mature theory. Work in progress will greatly improve the situation and may at last yield a compelling test. If so, and the relativistic model survives, it will close one line of research in cosmology: we will know the outlines of what happened as our universe expanded and cooled from high density. It will not end research: some of us will occupy ourselves with the details of how galaxies and other large-scale structures came to be the way they are, others with the issue of what our universe was doing before it was expanding. The former is being driven by rapid observational advances. The latter is being driven mainly by theory, but there are hints of observational guidance.Comment: 13 pages, 3 figures. To be published in PASP as part of the proceedings of the Smithsonian debate, Is Cosmology Solved

The Formation of Galactic Disks

We study the population of galactic disks expected in current hierarchical clustering models for structure formation. A rotationally supported disk with exponential surface density profile is assumed to form with a mass and angular momentum which are fixed fractions of those of its surrounding dark halo. We assume that haloes respond adiabatically to disk formation, and that only stable disks can correspond to real systems. With these assumptions the predicted population can match both present-day disks and the damped Lyman alpha absorbers in QSO spectra. Good agreement is found provided: (i) the masses of disks are a few percent of those of their haloes; (ii) the specific angular momenta of disks are similar to those of their haloes; (iii) present-day disks were assembled recently (at z<1). In particular, the observed scatter in the size-rotation velocity plane is reproduced, as is the slope and scatter of the Tully-Fisher relation. The zero-point of the TF relation is matched for a stellar mass-to-light ratio of 1 to 2 h in the I-band, consistent with observational values derived from disk dynamics. High redshift disks are predicted to be small and dense, and could plausibly merge together to form the observed population of elliptical galaxies. In many (but not all) currently popular cosmogonies, disks with rotation velocities exceeding 200 km/s can account for a third or more of the observed damped Lyman alpha systems at z=2.5. Half of the lines-of-sight to such systems are predicted to intersect the absorber at r>3kpc/h and about 10% at r>10kpc/h. The cross-section for absorption is strongly weighted towards disks with large angular momentum and so large size for their mass. The galaxy population associated with damped absorbers should thus be biased towards low surface brightness systems.Comment: 47 pages, Latex, aaspp4.sty, 14 figs included, submitted to MNRA

Effect of the W-term for a t-U-W Hubbard ladder

Antiferromagnetic and d_{x2-y2}-pairing correlations appear delicately balanced in the 2D Hubbard model. Whether doping can tip the balance to pairing is unclear and models with additional interaction terms have been studied. In one of these, the square of a local hopping kinetic energy H_W was found to favor pairing. However, such a term can be separated into a number of simpler processes and one would like to know which of these terms are responsible for enhancing the pairing. Here we analyze these processes for a 2-leg Hubbard ladder

Halo assembly bias and its effects on galaxy clustering

The clustering of dark halos depends not only on their mass but also on their assembly history, a dependence we term `assembly bias'. Using a galaxy formation model grafted onto the Millennium Simulation of the LCDM cosmogony, we study how assembly bias affects galaxy clustering. We compare the original simulation to `shuffled' versions where the galaxy populations are randomly swapped among halos of similar mass, thus isolating the effects of correlations between assembly history and environment at fixed mass. Such correlations are ignored in the halo occupation distribution models often used populate dark matter simulations with galaxies, but they are significant in our more realistic simulation. Assembly bias enhances 2-point correlations by 10% for galaxies with M_bJ-5logh brighter than -17, but suppresses them by a similar amount for galaxies brighter than -20. When such samples are split by colour, assembly bias is 5% stronger for red galaxies and 5% weaker for blue ones. Halo central galaxies are differently affected by assembly bias than are galaxies of all types. It almost doubles the correlation amplitude for faint red central galaxies. Shuffling galaxies among halos of fixed formation redshift or concentration in addition to fixed mass produces biases which are not much smaller than when mass alone is fixed. Assembly bias must reflect a correlation of environment with aspects of halo assembly which are not encoded in either of these parameters. It induces effects which could compromise precision measurements of cosmological parameters from large galaxy surveys.Comment: 8 pages, 4 figures, accepted for publication in MNRA

Charge ordering in doped manganese oxides: lattice dynamics and magnetic structure

Based on the Hamiltonian of small polarons with the strong nearest neighbor repulsion, we have investigated the charge ordering phenomena observed in half-doped manganites R_{1/2}A_{1/2}MnO_3. We have explored possible consequences of the charge ordering phase in the half-doped manganites. First, we have studied the renormalization of the sound velocity around $T_{CO}$, considering the acoustic phonons coupled to the electrons participating in the charge ordering. Second, we have found a new antiferromagnetic phase induced by the charge ordering, and discussed its role in connection with the specific CE-type antiferromagnetic structure observed in half-doped manganites.Comment: 5 pages, 2 Postscript figures. To appear in Phys. Rev. B - Rapid Comm. (01Jun97