2,848 research outputs found
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Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion
The global COVID-19 pandemic has become one of the largest clinical and operational challenges faced by emergency medicine, and our EDs continue to see increased volumes of infected patients, many of whom are not only ill, but acutely aware and fearful of their circumstances and potential mortality. Given this, there may be no more important time to focus on staff-patient communication and expression of compassion.However, many of the techniques usually employed by emergency clinicians to provide comfort to patients and their families are made more challenging or impossible by the current circumstances. Geriatric ED patients, who are at increased risk of severe disease, are particularly vulnerable to the effects of isolation.Despite many challenges, emergency clinicians have at their disposal a myriad of tools that can still be used to express compassion and empathy to their patients. Placing emphasis on using these techniques to maximize humanism in the care of COVID-19 patients during this crisis has the potential to bring improvements to ED patient care well after this pandemic has passed
Reconstructing the massive black hole cosmic history through gravitational waves
The massive black holes we observe in galaxies today are the natural
end-product of a complex evolutionary path, in which black holes seeded in
proto-galaxies at high redshift grow through cosmic history via a sequence of
mergers and accretion episodes. Electromagnetic observations probe a small
subset of the population of massive black holes (namely, those that are active
or those that are very close to us), but planned space-based gravitational-wave
observatories such as the Laser Interferometer Space Antenna (LISA) can measure
the parameters of ``electromagnetically invisible'' massive black holes out to
high redshift. In this paper we introduce a Bayesian framework to analyze the
information that can be gathered from a set of such measurements. Our goal is
to connect a set of massive black hole binary merger observations to the
underlying model of massive black hole formation. In other words, given a set
of observed massive black hole coalescences, we assess what information can be
extracted about the underlying massive black hole population model. For
concreteness we consider ten specific models of massive black hole formation,
chosen to probe four important (and largely unconstrained) aspects of the input
physics used in structure formation simulations: seed formation, metallicity
``feedback'', accretion efficiency and accretion geometry. For the first time
we allow for the possibility of ``model mixing'', by drawing the observed
population from some combination of the ``pure'' models that have been
simulated. A Bayesian analysis allows us to recover a posterior probability
distribution for the ``mixing parameters'' that characterize the fractions of
each model represented in the observed distribution. Our work shows that LISA
has enormous potential to probe the underlying physics of structure formation.Comment: 24 pages, 16 figures, submitted to Phys. Rev.
Probabilistic earthquake locations of induced seismicity in the Groningen region, the Netherlands
The Groningen gas reservoir, situated in the northeast of the Netherlands, is western Europe’s largest producing gas field and has been in production since 1963. The gas production has induced both subsidence and seismicity. Seismicity is detected and located using the Koninklijk Nederlands Meteorologisch Instituut shallow-borehole array for the period 2015–2017, incorporating the back projection techniques of QuakeMigrate and the nonlinear location procedure to constrain earthquake locations and depths. The uncertainties on the estimated depths are estimated taking into account velocity model, changes in station array geometry and uncertainties in the measurement of arrival times of the P and S waves. We show that the depth distribution of seismicity is consistent with nucleation within the reservoir (28 per cent) or in the overburden (60 per cent) within ∼500 m from the top of the reservoir. Earthquakes with hypocentres in the overburden likely originate from overlying Zechstein anhydrite caprock. Based on their depth distribution, it seems like the earthquakes are primarily driven by the elastic strain in the reservoir and overburden, induced by the reservoir compaction. We estimate the probability of earthquakes nucleating beneath the reservoir in the underlying Carboniferous limestone and basement, to be no more than 12 per cent
Oriented Three-Dimensional Magnetic Biskyrmion in MnNiGa Bulk Crystals
A biskyrmion consists of two bound, topologically stable skyrmion spin
textures. These coffee-bean-shaped objects have been observed in real-space in
thin plates using Lorentz transmission electron microscopy (LTEM). From LTEM
imaging alone, it is not clear whether biskyrmions are surface-confined
objects, or, analogously to skyrmions in non-centrosymmetric helimagnets,
three-dimensional tube-like structures in bulk sample. Here, we investigate the
biskyrmion form factor in single- and polycrystalline MnNiGa samples using
small angle neutron scattering (SANS). We find that biskyrmions are not
long-range ordered, not even in single-crystals. Surprisingly all of the
disordered biskyrmions have their in-plane symmetry axis aligned along certain
directions, governed by the magnetocrystalline anisotropy. This anisotropic
nature of biskyrmions may be further exploited to encode information
"Antiscepticism and Easy Justification" - Ch 5 of Seemings and Epistemic Justification
In this chapter I investigate epistemological consequences of the fact that seeming-based justification is elusive, in the sense that the subject can lose this justification simply by reflecting on her seemings. I argue that since seeming-based justification is elusive, the antisceptical bite of phenomenal conservatism is importantly limited. I also contend that since seeming-based justification has this feature, phenomenal conservatism isn’t actually afflicted by easy justification problems
Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast) due to an inability to sense or repair DNA damage by topoisomerase 2 (yTop2). We describe the characterization of LS1, identified in a high throughput screen for small molecules that shorten the replicative lifespan of yeast. LS1 accelerates aging without affecting proliferative growth or viability. Genetic and biochemical criteria reveal LS1 to be a weak Top2 poison. Top2 poisons induce the accumulation of covalent Top2-linked DNA double strand breaks that, if left unrepaired, lead to genome instability and death. LS1 is toxic to cells deficient in homologous recombination, suggesting that the damage it induces is normally mitigated by genome maintenance systems. The essential roles of yTop2 in proliferating cells may come with a fitness trade-off in older cells that are less able to sense or repair yTop2-mediated DNA damage. Consistent with this idea, cells live longer when yTop2 expression levels are reduced. These results identify intrinsic yTop2-mediated DNA damage as a potentially manageable cause of aging
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High-throughput smFRET analysis of freely diffusing nucleic acid molecules and associated proteins
Single-molecule Förster resonance energy transfer (smFRET) is a powerful technique for nanometer-scale studies of single molecules. Solution-based smFRET, in particular, can be used to study equilibrium intra- and intermolecular conformations, binding/unbinding events and conformational changes under biologically relevant conditions without ensemble averaging. However, single-spot smFRET measurements in solution are slow. Here, we detail a high-throughput smFRET approach that extends the traditional single-spot confocal geometry to a multispot one. The excitation spots are optically conjugated to two custom silicon single photon avalanche diode (SPAD) arrays. Two-color excitation is implemented using a periodic acceptor excitation (PAX), allowing distinguishing between singly- and doubly-labeled molecules. We demonstrate the ability of this setup to rapidly and accurately determine FRET efficiencies and population stoichiometries by pooling the data collected independently from the multiple spots. We also show how the high throughput of this approach can be used o increase the temporal resolution of single-molecule FRET population characterization from minutes to seconds. Combined with microfluidics, this high-throughput approach will enable simple real-time kinetic studies as well as powerful molecular screening applications
Influence of the Fermi Surface Morphology on the Magnetic Field-Driven Vortex Lattice Structure Transitions in YBaCuO0, 0.15
We report small-angle neutron scattering measurements of the vortex lattice
(VL) structure in single crystals of the lightly underdoped cuprate
superconductor YBa2Cu3O6.85. At 2 K, and for fields of up to 16 T applied
parallel to the crystal c-axis, we observe a sequence of field-driven and
first-order transitions between different VL structures. By rotating the field
away from the c-axis, we observe each structure transition to shift to either
higher or lower field dependent on whether the field is rotated towards the
[100] or [010] direction. We use this latter observation to argue that the
Fermi surface morphology must play a key role in the mechanisms that drive the
VL structure transitions. Furthermore, we show this interpretation is
compatible with analogous results obtained previously on lightly overdoped
YBa2Cu3O7. In that material, it has long-been suggested that the high field VL
structure transition is driven by the nodal gap anisotropy. In contrast, the
results and discussion presented here bring into question the role, if any, of
a nodal gap anisotropy on the VL structure transitions in both YBa2Cu3O6.85 and
YBa2Cu3O7
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