Small-Scale structure in the Galactic ISM: Implications for Galaxy Cluster Studies

Observations of extragalactic objects need to be corrected for Galactic absorption and this is often accomplished by using the measured 21 cm HI column. However, within the beam of the radio telescope there are variations in the HI column that can have important effects in interpreting absorption line studies and X-ray spectra at the softest energies. We examine the HI and DIRBE/IRAS data for lines of sight out of the Galaxy, which show evidence for HI variations in of up to a factor of three in 1 degree fields. Column density enhancements would preferentially absorb soft X-rays in spatially extended objects and we find evidence for this effect in the ROSAT PSPC observations of two bright clusters of galaxies, Abell 119 and Abell 2142. For clusters of galaxies, the failure to include column density fluctuations will lead to systematically incorrect fits to the X-ray data in the sense that there will appear to be a very soft X-ray excess. This may be one cause of the soft X-ray excess in clusters, since the magnitude of the effect is comparable to the observed values.Comment: 16 pages, 9 figures, to appear in the Astrophysical Journal, vol. 597 (1 Nov 2003

Understanding Seafood Consumption and Healthy Living Practices Report 2010

This report documents the findings of a small cross-sectional survey conducted from November 6 - 9th 2010. The survey was administered to 48 people via random interception at the Melbourne Exhibition Centre. Respondents were asked to complete demographic information, consumption and perception of seafood to other proteins (chicken, pork, lamb and beef), what types of seafood consumed in the past week and the preparation methods used. Respondents were also asked whether they participated in physical activities and what barriers they had to recreational fishing. Although the sample size was small, this study provided validation to the survey instrument used. Reliability will now be assessed and the survey modified accordingly for use in a larger study to be conducted through CESSH. The study has also provided some direction for further work within a community based model of behaviour change communication

Examination of an Anecdotal “October Disappearance” of Northern Bobwhite in the Rolling Plains of Texas Through Demographic Data

Landowners and wildlife managers in the Rolling Plains ecological region of Texas, USA often report encountering northern bobwhite (Colinus virginianus; hereafter, bobwhite) in summer but observe what they perceive as a decrease in quail by early to mid-fall. As most bobwhite research in the Rolling Plains is focused on either breeding season or overwinter survival and movement, researchers rarely record demographic data during this late summer and early fall period. We examined weekly survival probabilities of bobwhite (n = 244) across 7 sites in the western Rolling Plains Ecoregion from August to late November in 2016, 2017, 2019, and 2020. Bobwhites were captured and equipped with very high frequency (VHF) transmitters and tracked 1–5 times/week. We used Akaike’s Information Criterion adjusted for small sample sizes (AICc) to evaluate a suite of candidate models comparing survival among and between years and survival between individual weeks to determine whether an unreported population decrease occurred during the study years. Our comparison of weekly survival probabilities considered survival to be different if 95% confidence intervals did not overlap. Our best supported model held survival constant among years and allowed survival to vary week by week. All other models received little support (ΔAICc \u3e 14.0). Examination of weekly survival probabilities failed to support a demographically driven hypothesis for decreased bobwhite observations from August to November. Though there was an observed decrease of weekly survival in the fourth week of September, it was not different than 16 of the 17 other weeks. We conclude that, for the years we measured, there was no support for a mass die-off hypothesis. Factors outside survival (e.g., a change in bobwhite behavior) may be driving the difference in detectability between late summer and late fall in the Rolling Plains of Texas

An evaluation of the performance of the Dynamiker® Fungus (1-3)-β-D-Glucan Assay to 2 assist in the diagnosis of Pneumocystis pneumonia

Invasive fungal disease (IFD) can be caused by a range of pathogens. Conventional diagnosis has the capacity to detect most causes of IFD, but poor performance limits impact. The introduction of non-culture diagnostics, including the detection of (1-3)-β-D-Glucan (BDG), has shown promising performance for the detection of IFD in variety of clinical settings. Recently, the Dynamiker® Fungus (1-3)-β-D-Glucan assay (D-BDG) was released as an IFD diagnostic test. This article describes an evaluation of the D-BDG assay for the diagnosis of invasive aspergillosis (IA), invasive candidiasis (IC) and Pneumocystis pneumonia (PCP) across several high-risk patient cohorts and provides comparative data with the Associates of Cape Cod Fungitell® and BioRad Platelia™ Aspergillus Ag (GM) assays. There were 163 serum samples from 121 patients tested, from 21 probable IA cases, 28 proven IC cases, six probable PCP cases, one probable IFD case, 14 possible IFD cases and 64 control patients. For proven/probable IFD the mean BDG concentration was 209pg/ml, significantly greater than the control population (73pg/ml; P: <.0001). The sensitivity, specificity, and diagnostic odds ratio for proven/probable IFD was 81.4%, 78.1%, and 15.5, respectively. Significant BDG false positivity (9/13) was associated post abdominal surgery. D-BDG showed fair and good agreement with the Fungitell®, and GM assays, respectively. In conclusion, the D-BDG provides a useful adjunct test to aid the diagnosis of IFD, with technical flexibility that will assist laboratories processing low sample numbers. Further, large scale, prospective evaluation is required to confirm the clinical validity and determine clinical utility

Community intervention to increase seafood consumption (CIISC)

In summary, this report describes a whole of community intervention aimed at increasing consumption of seafood. The health benefits of seafood were reviewed and a suit of communication materials developed including: primary and secondary education models. vocational eductaion materials, resources for general practitioners and point of sale materials. Evaluation of project outcomes revealed an increase in seafood consumption during and one month after the intervention period

eB4CAST: An Evidence-Based Tool to Promote Dissemination and Implementation in Community-Based, Public Health Research

eB4CAST, evidence-Based forecast C-capture, A-assemble, S-sustain, T-timelessness (eB4CAST), framework was developed from existing dissemination and implementation (D & I) constructs as a dissemination tool to promote community-based program usability and future application in targeted populations. eB4CAST captures and transforms research findings into a dissemination report that shows program need and impact to endorse program continuation and expansion. This is achieved through direct and indirect data collection of community factors and program impact that can showcase the need for program sustainability and potential for future dissemination sites. Testimonials, individual feedback, and program process and outcomes contribute to the direct data while data collected from census, county, and state databases and reports allow for indirect information to be captured and analyzed. Capturing data in the two levels allow eB4CAST to forecast program need and highlight program impact through a footprint. eB4CAST framework for dissemination tool creation is organized into four sections: Capture, Assemble, Sustainability, and Timelessness. Capture encompasses the collection of indirect and direct data related to intervention goals. Assemble is the compilation of the data into a visually appealing and easily understood media. Sustainability encourages the use of dissemination tools to provide forecast of program need and footprint of program impact back to community participants, program leaders, and key stakeholders to endorse program sustainability. Lastly, timelessness encourages cyclic movement through these constructs to continue program monitoring and data sharing to ensure timeless program evaluation and conformation to change in needs. The eB4CAST framework provides a systematic method to capture justification of program need and impact of community-based research that can be modified to fit diverse public health interventions providing a necessary D & I tool

Brain abscess and stroke in children and adults with hereditary hemorrhagic telangiectasia: Analysis of a large national claims database

BACKGROUND AND OBJECTIVES: Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease associated with pathogenic variants in transforming growth factor-β signaling pathway-related genes, resulting in abnormal vascular development in various organs. Brain arteriovenous malformations (AVMs) may lead to intracranial hemorrhage, and brain abscess or ischemic stroke may result from right to left shunting via pulmonary AVMs. We aimed to investigate the risk for these severe complications in both adults and children with HHT. METHODS: We conducted a case-control study among participants aged 1-64 years in the MarketScan Commercial (2006-2019) and Multistate Medicaid Databases (2011-2019). We identified cases with HHT using RESULTS: A total of 5,796 patients with HHT, of whom 588 were children (age younger than 16 years), were matched with 57,960 controls. There was an increased incidence of brain abscesses in HHT cases compared with controls, with an RR of 35.6 (95% CI 15.4-82.5). No brain abscesses were recorded in children aged 15 years or younger. Hemorrhagic strokes/subarachnoid hemorrhages were more common in HHT cases, with an RR of 4.01 (95% CI 2.8-5.7) in adults and 60.2 (95% CI 7.2-500.4) in children. Ischemic strokes were also more common in cases, with an RR of 3.7 (95% CI, 3.0-4.5) in adults and 70.4 (95% CI 8.7-572.3) in children. DISCUSSION: We observed a much higher incidence of severe CNS vascular complications in patients with HHT, particularly in children. Although a higher incidence of brain abscesses was noted in adult patients with HHT, no brain abscesses were recorded in children, a result that may be considered when surveillance recommendations for this population are revisited

Radio observations of the planetary nebula around the OH/IR Star OH354.88-0.54 (V1018 Sco)

We present radio observations of the unique, recently formed, planetary nebula (PN) associated with a very long-period OH/IR variable star V1018 Sco that is unequivocally still in its asymptoticgiant branch phase. Two regions within the optical nebula are clearly detected in nonthermal radio continuum emission, with radio spectral indices comparable to those seen in colliding-wind Wolf-Rayet binaries. We suggest that these represent shocked interactions between the hot, fast stellar wind and the cold nebular shell that represents the PN's slow wind moving away from the central star. This same interface produces both synchrotron radio continuum and the optical PN emission. The fast wind is neither spherical in geometry nor aligned withany obvious optical or radio axis. We also report the detection of transient H2O maser emission in this nebula.Comment: 11 pages, LaTeX (mn2e.cls), incl. 9 PostScript (ps or eps) figures and 2 tables. Accepted by MNRA

Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer

BACKGROUND: Long intergenic non-coding RNAs (lncRNAs) represent an emerging and under-studied class of transcripts that play a significant role in human cancers. Due to the tissue- and cancer-specific expression patterns observed for many lncRNAs it is believed that they could serve as ideal diagnostic biomarkers. However, until each tumor type is examined more closely, many of these lncRNAs will remain elusive. RESULTS: Here we characterize the lncRNA landscape in lung cancer using publicly available transcriptome sequencing data from a cohort of 567 adenocarcinoma and squamous cell carcinoma tumors. Through this compendium we identify over 3,000 unannotated intergenic transcripts representing novel lncRNAs. Through comparison of both adenocarcinoma and squamous cell carcinomas with matched controls we discover 111 differentially expressed lncRNAs, which we term lung cancer-associated lncRNAs (LCALs). A pan-cancer analysis of 324 additional tumor and adjacent normal pairs enable us to identify a subset of lncRNAs that display enriched expression specific to lung cancer as well as a subset that appear to be broadly deregulated across human cancers. Integration of exome sequencing data reveals that expression levels of many LCALs have significant associations with the mutational status of key oncogenes in lung cancer. Functional validation, using both knockdown and overexpression, shows that the most differentially expressed lncRNA, LCAL1, plays a role in cellular proliferation. CONCLUSIONS: Our systematic characterization of publicly available transcriptome data provides the foundation for future efforts to understand the role of LCALs, develop novel biomarkers, and improve knowledge of lung tumor biology. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-014-0429-8) contains supplementary material, which is available to authorized users