Employer engagement within 14-19 diploma development

In 2005, the UK government announced the development of a suite of employer-designed diplomas for 14-19 year olds linked to different industrial and commercial sectors. This article will reflect on some of the achievements and challenges of this major employer engagement initiative by drawing on three pieces of research: a review of Diploma development and two employer consultation studies belonging to the latest phase of Diploma development - the Diplomas in Humanities and Social Sciences and Languages and International Communications. The article suggests that meeting the needs of employers in qualification design is problematic as employers are a heterogeneous group bringing a range of different views, ideas and contributions to the process. Furthermore, the article points to a possible mismatch between policymakers' expectations from employers at the macro level, and what in fact happens at the local, micro level owing to personal and economic circumstances, companies' demands and the economic climate

Twenty Things: Archives and Development in Collaboration

Special collections librarians and archivists are committed to caring for their unique collections and making them accessible to users. Library development staff are equally dedicated to the library and its collections and services. Both may play roles in fostering relationships with donors and bringing in donations—but how and when do they need to really work together, and to do so effectively? Kim Fill, Assistant Director of Development and Donor Relations, and Caroline White, Archives and Manuscript Librarian, both at UMass Amherst Libraries, have been colleagues for nearly seven years, and even they aren’t entirely sure what each other does. With a light touch and a serious intent, each will share five things they want the other to know about what they do and five questions they have for the other department. Such issues as collecting policies and goals, what makes a collection “valuable,” working with “small” donors for big returns, balancing the goals and directives of your library with those of central advancement, taking the long view, and more will be covered, with time for attendees to share their own comments and questions. *NOTE: We are open to partnering with another library team on this session

Family mealtimes and eating psychopathology : the role of anxiety and depression among adolescent girls and boys

Characteristics of family mealtimes are associated with disordered eating behaviours. However, little is known about the relationships between characteristics of family mealtimes and disordered eating attitudes, or how symptoms of anxiety or depression may contribute to these relationships. This study therefore aimed to examine differences between adolescent girls and boys in the relationship between family mealtime characteristics and eating psychopathology, and to explore the influence of anxiety and depression on this relationship. Adolescents (N=535; 286 girls and 249 boys) aged 14-18 years completed self-report measures of family mealtime characteristics, eating psychopathology, anxiety and depression. Reports of more frequent family mealtimes, a more positive mealtime atmosphere and a high level of priority placed on mealtimes were all associated with significantly lower levels of eating-disordered attitudes among girls only. For boys, all four mealtime measures (higher mealtime frequency, more positive mealtime atmosphere, greater priority of mealtimes and higher levels of mealtime structure) were associated with lower levels of depression. Among girls, several of the family mealtime and eating psychopathology relationships were partially or fully mediated by either anxiety or depression. While these findings require longitudinal replication, family mealtimes are likely to be important in promoting psychological well-being among both girls and boys. Families should be encouraged to think beyond the frequency of mealtimes and to foster a positive mealtime environment which may help to promote adolescent psychological well being, and might even protect young females against the development of eating psychopathology

Effect of ambient temperature during acute aerobic exercise on short-term appetite, energy intake, and plasma acylated ghrelin in recreationally active males

Ambient temperature during exercise may affect energy intake regulation. Compared with a temperate (20 °C) environment, 1 h of running followed by 6 h of rest tended to decrease energy intake from 2 ad libitum meals in a hot (30 °C) environment but increase energy intake in a cool (10 °C) environment (p = 0.08). Core temperature changes did not appear to mediate this trend; whether acylated ghrelin is involved is unclear. Further research is warranted to clarify these findings

Eating disorder examination questionnaire : factor structure for adolescent girls and boys

Objective: To examine the factor structure of the EDE-Q among a sample of adolescents. Method: A community-based sample of 917 adolescents (522 girls and 395 boys) aged 14-18 years completed the EDE-Q version 6.0 as part of a larger study. Participants were randomly assigned to one of two subsamples to enable separate analyses. Results: A confirmatory factor analysis on the original four factor model of the EDE-Q produced an inadmissible model with a poor fit. Exploratory factor analysis using principal axis factoring produced an alternative three factor model of the EDE-Q among adolescents. The Shape and Weight Concerns, Restriction and Preoccupation and Eating Concern subscales accounted for 65% of the total variance. Subscale and global scores were significantly higher for girls than for boys. A high proportion of both girls (53.6%) and boys (30.5%) reported participating in at least one key eating disordered behaviour during the previous 28 days. Discussion: The results of this study present three new subscales (Shape and Weight Concerns, Restriction and Preoccupation and Eating Concern) which are suggested for use in future research which uses the EDE-Q with community samples of adolescents

Mathematical Models for a New Era of Malaria Eradication

Maciej Boni and colleagues discuss a new model exploring how a switch in antimalarial drug use to artemisinin-based combination therapies will affect malaria prevalence and incidence in endemic regions

Cenozoic evolution of the eastern Black Sea: a test of depth-dependent stretching models

Subsidence analysis of the eastern Black Sea basin suggests that the stratigraphy of this deep, extensional basin can be explained by a predominantly pure-shear stretching history. A strain-rate inversion method that assumes pure-shear extension obtains good fits between observed and predicted stratigraphy. A relatively pure-shear strain distribution is also obtained when a strain-rate inversion algorithm is applied that allows extension to vary with depth without assuming its existence or form. The timing of opening of the eastern Black Sea, which occupied a back-arc position during the closure of the Tethys Ocean, has also been a subject of intense debate; competing theories called for basin opening during the Jurassic, Cretaceous or Paleocene/Eocene. Our work suggests that extension likely continued into the early Cenozoic, in agreement with stratigraphic relationships onshore and with estimates for the timing of arc magmatism. Further basin deepening also appears to have occurred in the last 20 myr. This anomalous subsidence event is focused in the northern part of the basin and reaches its peak at 15–10 Ma. We suggest that this comparatively localized shortening is associated with the northward movement of the Arabian plate. We also explore the effects of paleowater depth and elastic thickness on the results. These parameters are controversial, particularly for deep-water basins and margins, but their estimation is a necessary step in any analysis of the tectonic subsidence record stored in stratigraphy. <br/

Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis

Mcl-1 is a member of the Bcl2-related protein family that is a critical mediator of cell survival. Exposure of cells to stress causes inhibition of Mcl-1 mRNA translation and rapid destruction of Mcl-1 protein by proteasomal degradation mediated by a phosphodegron created by glycogen synthase kinase 3 (GSK3) phosphorylation of Mcl-1. Here we demonstrate that prior phosphorylation of Mcl-1 by the c-Jun N-terminal protein kinase (JNK) is essential for Mcl-1 phosphorylation by GSK3. Stress-induced Mcl-1 degradation therefore requires the coordinated activity of JNK and GSK3. Together, these data establish that Mcl-1 functions as a site of signal integration between the proapoptotic activity of JNK and the prosurvival activity of the AKT pathway that inhibits GSK3

Properties of Healthcare Teaming Networks as a Function of Network Construction Algorithms

Network models of healthcare systems can be used to examine how providers collaborate, communicate, refer patients to each other. Most healthcare service network models have been constructed from patient claims data, using billing claims to link patients with providers. The data sets can be quite large, making standard methods for network construction computationally challenging and thus requiring the use of alternate construction algorithms. While these alternate methods have seen increasing use in generating healthcare networks, there is little to no literature comparing the differences in the structural properties of the generated networks. To address this issue, we compared the properties of healthcare networks constructed using different algorithms and the 2013 Medicare Part B outpatient claims data. Three different algorithms were compared: binning, sliding frame, and trace-route. Unipartite networks linking either providers or healthcare organizations by shared patients were built using each method. We found that each algorithm produced networks with substantially different topological properties. Provider networks adhered to a power law, and organization networks to a power law with exponential cutoff. Censoring networks to exclude edges with less than 11 shared patients, a common de-identification practice for healthcare network data, markedly reduced edge numbers and greatly altered measures of vertex prominence such as the betweenness centrality. We identified patterns in the distance patients travel between network providers, and most strikingly between providers in the Northeast United States and Florida. We conclude that the choice of network construction algorithm is critical for healthcare network analysis, and discuss the implications for selecting the algorithm best suited to the type of analysis to be performed.Comment: With links to comprehensive, high resolution figures and networks via figshare.co

Let the sun shine in: effects of ultraviolet radiation on invasive pneumococcal disease risk in Philadelphia, Pennsylvania

BACKGROUND: Streptococcus pneumoniae is a common cause of community acquired pneumonia and bacteremia. Excess wintertime mortality related to pneumonia has been noted for over a century, but the seasonality of invasive pneumococcal disease (IPD) has been described relatively recently and is poorly understood. Improved understanding of environmental influence on disease seasonality has taken on new urgency due to global climate change. METHODS: We evaluated 602 cases of IPD reported in Philadelphia County, Pennsylvania, from 2002 to 2007. Poisson regression models incorporating seasonal smoothers were used to identify associations between weekly weather patterns and case counts. Associations between acute (dayto- day) environmental fluctuations and IPD occurrence were evaluated using a case-crossover approach. Effect modification across age and sex strata was explored, and meta-regression models were created using stratum-specific estimates for effect. RESULTS: IPD incidence was greatest in the wintertime, and spectral decomposition revealed a peak at 51.0 weeks, consistent with annual periodicity. After adjustment for seasonality, yearly increases in reporting, and temperature, weekly incidence was found to be associated with clear-sky UV index (IRR per unit increase in index: 0.70 [95% CI 0.54-0.91]). The effect of UV index was highest among young strata and decreased with age. At shorter time scales, only an association with increases in ambient sulphur oxides was linked to disease risk (OR for highest tertile of exposure 0.75, 95% CI 0.60 to 0.93). CONCLUSION: We confirmed the wintertime predominance of IPD in a major urban center. The major predictor of IPD in Philadelphia is extended periods of low UV radiation, which may explain observed wintertime seasonality. The mechanism of action of diminished light exposure on disease occurrence may be due to direct effects on pathogen survival or host immune function via altered 1,25-(OH)2-vitamin-D metabolism. These findings may suggest less diminution in future IPD risk with climate change than would be expected if wintertime seasonality was driven by temperature