12,550 research outputs found
Launch vehicle wind and turbulence response by nonstationary statistical methods
Nonstationary adjoint algorithm for determining launch vehicle flight loads due to winds and turbulenc
The Convective Urca Process with Implicit Two-Dimensional Hydrodynamics
Consideration of the role of the convective flux in the thermodymics of the
convective Urca neutrino loss process in degenerate, convective, quasi-static,
carbon-burning cores shows that the convective Urca process slows down the
convective current around the Urca-shell, but, unlike the "thermal" Urca
process, does not reduce the entropy or temperature for a given convective
volume. Here we demonstrate these effects with two-dimensional numerical
hydrodynamical calculations. These two-dimensional implicit hydrodynamics
calculations invoke an artificial speeding up of the nuclear and weak rates.
They should thus be regarded as indicative, but still qualitative. We find
that, compared to a case with no Urca-active nuclei, the case with Urca effects
leads to a higher entropy in the convective core because the energy released by
nuclear burning is confined to a smaller volume by the effective boundary at
the Urca shell. All else being equal, this will tend to accelerate the
progression to dynamical runaway. We discuss the open issues regarding the
impact of the convective Urca process on the evolution to the "smoldering
phase" and then to dynamical runaway.Comment: 22 pages, 11 figures, accepted for publication in the Astrophysical
Journa
Phase field modeling of electrochemistry II: Kinetics
The kinetic behavior of a phase field model of electrochemistry is explored
for advancing (electrodeposition) and receding (electrodissolution) conditions
in one dimension. We described the equilibrium behavior of this model in [J. E.
Guyer, W. J. Boettinger, J.A. Warren, and G. B. McFadden, ``Phase field
modeling of electrochemistry I: Equilibrium'', cond-mat/0308173]. We examine
the relationship between the parameters of the phase field method and the more
typical parameters of electrochemistry. We demonstrate ohmic conduction in the
electrode and ionic conduction in the electrolyte. We find that, despite making
simple, linear dynamic postulates, we obtain the nonlinear relationship between
current and overpotential predicted by the classical ``Butler-Volmer'' equation
and observed in electrochemical experiments. The charge distribution in the
interfacial double layer changes with the passage of current and, at
sufficiently high currents, we find that the diffusion limited deposition of a
more noble cation leads to alloy deposition with less noble species.Comment: v3: To be published in Phys. Rev. E v2: Attempt to work around
turnpage bug. Replaced color Fig. 4a with grayscale 13 pages, 7 figures in 10
files, REVTeX 4, SIunits.sty, follows cond-mat/030817
Corticosterone Regulates Both Naturally Occurring and CocaineâInduced Dopamine Signaling by Selectively Decreasing Dopamine Uptake
Stressful and aversive events promote maladaptive rewardâseeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to produce a synergistic effect on reward circuitry. This effect is also observed when the stress hormone corticosterone is administered directly into the nucleus accumbens (NAc), indicating that glucocorticoids act locally in dopamine terminal regions to enhance cocaine\u27s effects on dopamine signaling. However, prior studies in behaving animals have not provided mechanistic insight. Using fastâscan cyclic voltammetry, we examined the effect of systemic corticosterone on spontaneous dopamine release events (transients) in the NAc core and shell in behaving rats. A physiologically relevant systemic injection of corticosterone (2 mg/kg i.p.) induced an increase in dopamine transient amplitude and duration (both voltammetric measures sensitive to decreases in dopamine clearance), but had no effect on the frequency of transient release events. This effect was compounded by cocaine (2.5 mg/kg i.p.). However, a second experiment indicated that the same injection of corticosterone had no detectable effect on the dopaminergic encoding of a palatable natural reward (saccharin). Taken together, these results suggest that corticosterone interferes with naturally occurring dopamine uptake locally, and this effect is a critical determinant of dopamine concentration specifically in situations in which the dopamine transporter is pharmacologically blocked by cocaine
Understanding light quanta: First quantization of the free electromagnetic field
The quantization of the electromagnetic field in vacuum is presented without
reference to lagrangean quantum field theory. The equal time commutators of the
fields are calculated from basic principles. A physical discussion of the
commutators suggest that the electromagnetic fields are macroscopic emergent
properties of more fundamental physical system: the photons
Uncertainty Relation Revisited from Quantum Estimation Theory
By invoking quantum estimation theory we formulate bounds of errors in
quantum measurement for arbitrary quantum states and observables in a
finite-dimensional Hilbert space. We prove that the measurement errors of two
observables satisfy Heisenberg's uncertainty relation, find the attainable
bound, and provide a strategy to achieve it.Comment: manuscript including 4 pages and 2 figure
Social inclusion: Context, theory and practice
This paper reviews the literature on social inclusion in Australia and provides an overview of the current situation regarding university/community engagement. Social inclusion is a contested term in both academic and policy literature entailing a range of interpretations. The paper will argue that there is a spectrum of ideological positions underlying theory, policy and practice. The broad theoretical construct put forward regards social inclusion in relation to areas (who is to be included?) and degrees (ideologies) of inclusion. Possible areas of inclusion are socioâeconomic status, culture (including indigenous cultures), linguistic group, religion, geography (rural and remote/isolated), gender, sexual orientation, age (including youth and old age), physical and mental health/ability, and status with regard to unemployment, homelessness and incarceration. Degree of inclusion comprises a nested threefold schema incorporating a spectrum of ideologies involvingâfrom narrowest to most encompassingâthe neoliberal focus on access and economic factors, the social justice focus on community participation and the human potential focus on personal and collective empowerment stemming from positive psychology and critical/transformative pedagogies. Contemporary Australian social inclusion policy is related to UK policy. While policy rhetoric indicates a broad interpretation of social inclusion, concerns are raised that a dominant Economicist agenda favours corporate and national economic interests over social and psychological ones. Questions are also raised about the privileging of some areas of inclusion over others and the possibility that reductive interpretations of social inclusion are forms of cultural assimilation. Social inclusion in practice is addressed both in relation to degrees of inclusion and through case studies. The paper provides an overview of examples of social inclusion interventions, including a review of two initiatives of RMIT University and Victoria University focussing on industry/community partnerships. The paper concludes with some challenges and issues for further research on social inclusion including a proposed in-depth survey and consideration of literature on integrative phenomena such as ecological sustainability, and contextualisation of social inclusion within broader movements of global socioâcultural change
Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking
Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood. Studies suggest that stress may âset the stageâ for relapse by increasing the sensitivity of brain reward circuits to drug-associated stimuli. We examined the effects of stress and corticosterone on behavioral and neurochemical responses of rats to a cocaine prime after cocaine self-administration and extinction. Exposure of rats to acute electric footshock stress did not by itself reinstate drug-seeking behavior but potentiated reinstatement in response to a subthreshold dose of cocaine. This effect of stress was not observed in adrenalectomized animals, and was reproduced in nonstressed animals by administration of corticosterone at a dose that reproduced stress-induced plasma levels. Pretreatment with the glucocorticoid receptor antagonist RU38486 did not block the corticosterone effect. Corticosterone potentiated cocaine-induced increases in extracellular dopamine in the nucleus accumbens (NAc), and pharmacological blockade of NAc dopamine receptors blocked corticosterone-induced potentiation of reinstatement. Intra-accumbens administration of corticosterone reproduced the behavioral effects of stress and systemic corticosterone. Corticosterone treatment acutely decreased NAc dopamine clearance measured by fast-scan cyclic voltammetry, suggesting that inhibition of uptake2-mediated dopamine clearance may underlie corticosterone effects. Consistent with this hypothesis, intra-accumbens administration of the uptake2 inhibitor normetanephrine potentiated cocaine-induced reinstatement. Expression of organic cation transporter 3, a corticosterone-sensitive uptake2 transporter, was detected on NAc neurons. These findings reveal a novel mechanism by which stress hormones can rapidly regulate dopamine signaling and contribute to the impact of stress on drug intake
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