352 research outputs found
Vacuum polarization of a scalar field in wormhole spacetimes
An analitical approximation of for a scalar field in a static
spherically symmetric wormhole spacetime is obtained. The scalar field is
assumed to be both massive and massless, with an arbitrary coupling to
the scalar curvature, and in a zero temperature vacuum state.Comment: 10 pages, RevTeX, two eps figure
Are Wikis and Weblogs an Appropriate Approach to Foster Collaboration, Reflection and Students’ Motivation?
Reconfigurable microfluidic circuits for isolating and retrieving cells of interest
Microfluidic devices are widely used in many fields of biology, but a key limitation is that cells are typically surrounded by solid walls, making it hard to access those that exhibit a specific phenotype for further study. Here, we provide a general and flexible solution to this problem that exploits the remarkable properties of microfluidic circuits with fluid walls─transparent interfaces between culture media and an immiscible fluorocarbon that are easily pierced with pipets. We provide two proofs of concept in which specific cell subpopulations are isolated and recovered: (i) murine macrophages chemotaxing toward complement component 5a and (ii) bacteria (Pseudomonas aeruginosa) in developing biofilms that migrate toward antibiotics. We build circuits in minutes on standard Petri dishes, add cells, pump in laminar streams so molecular diffusion creates attractant gradients, acquire time-lapse images, and isolate desired subpopulations in real time by building fluid walls around migrating cells with an accuracy of tens of micrometers using 3D printed adaptors that convert conventional microscopes into wall-building machines. Our method allows live cells of interest to be easily extracted from microfluidic devices for downstream analyses
Analytic Solutions of The Wheeler-DeWitt Equation in Spherically Symmetric Space-time
We study the quantum theory of the Einstein-Maxwell action with a
cosmological term in the spherically symmetric space-time, and explored quantum
black hole solutions in Reissner-Nordstrom-de Sitter geometry. We succeeded to
obtain analytic solutions to satisfy both the energy and momentum constraints.Comment: LaTeX file, 15 page
EPR-Bell Nonlocality, Lorentz Invariance, and Bohmian Quantum Theory
We discuss the problem of finding a Lorentz invariant extension of Bohmian
mechanics. Due to the nonlocality of the theory there is (for systems of more
than one particle) no obvious way to achieve such an extension. We present a
model invariant under a certain limit of Lorentz transformations, a limit
retaining the characteristic feature of relativity, the non-existence of
absolute time resp. simultaneity. The analysis of this model exemplifies an
important property of any Bohmian quantum theory: the quantum equilibrium
distribution cannot simultaneously be realized in all
Lorentz frames of reference.Comment: 24 pages, LaTex, 4 figure
Recommended from our members
RESIDUAL STRESS AND DEFORMATION ANALYSIS OF INCONEL 718 ACROSS VARYING OVERHANGS IN LASER POWDER BLOWN DIRECTED ENERGY DEPOSITION
Any metal that is subjected to rapid heat and cooling will undergo the development of
residual stresses. As they experience intense temperature fluctuations, this will consequently alter
the way the material will behave. This issue proves to be of great concern within additive
manufacturing. That said, the presence of temperature fluctuations is more prominent in Directed
energy deposition (DED), whereas other methods of manufacturing are more prominent in the
pre- or post- printing process. This in turn means the deformation, as well as the redistribution of
the residual stresses within pieces, are subject to variance by several process parameters set
during a print. By using the Inconel 718 alloy feedstock in RPMI’s Laser Powder Directed
Energy Deposition (LP-DED) printer, a series of coupons with four different overhang angles
and laser power outputs will determine how these changes thermo-mechanically affect the prints
through the use of FEA simulations and scans.Mechanical Engineerin
Expanding and Collapsing Scalar Field Thin Shell
This paper deals with the dynamics of scalar field thin shell in the
Reissner-Nordstrm geometry. The Israel junction conditions between
Reissner-Nordstrm spacetimes are derived, which lead to the equation
of motion of scalar field shell and Klien-Gordon equation. These equations are
solved numerically by taking scalar field model with the quadratic scalar
potential. It is found that solution represents the expanding and collapsing
scalar field shell. For the better understanding of this problem, we
investigate the case of massless scalar field (by taking the scalar field
potential zero). Also, we evaluate the scalar field potential when is an
explicit function of . We conclude that both massless as well as massive
scalar field shell can expand to infinity at constant rate or collapse to zero
size forming a curvature singularity or bounce under suitable conditions.Comment: 15 pages, 11 figure
Roadmap on Li-ion battery manufacturing research
Growth in the Li-ion battery market continues to accelerate, driven primarily by the increasing need for economic energy storage for electric vehicles. Electrode manufacture by slurry casting is the first main step in cell production but much of the manufacturing optimisation is based on trial and error, know-how and individual expertise. Advancing manufacturing science that underpins Li-ion battery electrode production is critical to adding to the electrode manufacturing value chain. Overcoming the current barriers in electrode manufacturing requires advances in materials, manufacturing technology, in-line process metrology and data analytics, and can enable improvements in cell performance, quality, safety and process sustainability. In this roadmap we explore the research opportunities to improve each stage of the electrode manufacturing process, from materials synthesis through to electrode calendering. We highlight the role of new process technology, such as dry processing, and advanced electrode design supported through electrode level, physics-based modelling. Progress in data driven models of electrode manufacturing processes is also considered. We conclude there is a growing need for innovations in process metrology to aid fundamental understanding and to enable feedback control, an opportunity for electrode design to reduce trial and error, and an urgent imperative to improve the sustainability of manufacture
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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