Analysis of power-saving techniques over a large multi-use cluster with variable workload

Reduction of power consumption for any computer system is now an important issue, although this should be carried out in a manner that is not detrimental to the users of that computer system. We present a number of policies that can be applied to multi-use clusters where computers are shared between interactive users and high-throughput computing. We evaluate policies by trace-driven simulations to determine the effects on power consumed by the high-throughput workload and impact on high-throughput users. We further evaluate these policies for higher workloads by synthetically generating workloads based around the profiled workload observed through our system. We demonstrate that these policies could save 55% of the currently used energy for our high-throughput jobs over our current cluster policies without affecting the high-throughput users’ experience

3D Correlative Imaging of Lithium Ion Concentration in a Vertically Oriented Electrode Microstructure with a Density Gradient

The performance of Li+ ion batteries (LIBs) is hindered by steep Li+ ion concentration gradients in the electrodes. Although thick electrodes (≥300 µm) have the potential for reducing the proportion of inactive components inside LIBs and increasing battery energy density, the Li+ ion concentration gradient problem is exacerbated. Most understanding of Li+ ion diffusion in the electrodes is based on computational modeling because of the low atomic number (Z) of Li. There are few experimental methods to visualize Li+ ion concentration distribution of the electrode within a battery of typical configurations, for example, coin cells with stainless steel casing. Here, for the first time, an interrupted in situ correlative imaging technique is developed, combining novel, full-field X-ray Compton scattering imaging with X-ray computed tomography that allows 3D pixel-by-pixel mapping of both Li+ stoichiometry and electrode microstructure of a LiNi0.8 Mn0.1 Co0.1 O2 cathode to correlate the chemical and physical properties of the electrode inside a working coin cell battery. An electrode microstructure containing vertically oriented pore arrays and a density gradient is fabricated. It is shown how the designed electrode microstructure improves Li+ ion diffusivity, homogenizes Li+ ion concentration through the ultra-thick electrode (1 mm), and improves utilization of electrode active materials

Deconfinement transition and string tensions in SU(4) Yang-Mills Theory

We present results from numerical lattice calculations of SU(4) Yang-Mills theory. This work has two goals: to determine the order of the finite temperature deconfinement transition on an $N_t = 6$ lattice and to study the string tensions between static charges in the irreducible representations of SU(4). Motivated by Pisarski and Tytgat's argument that a second-order SU($\infty$) deconfinement transition would explain some features of the SU(3) and QCD transitions, we confirm older results on a coarser, $N_t = 4$, lattice. We see a clear two-phase coexistence signal, characteristic of a first-order transition, at $8/g^2 = 10.79$ on a $6\times 20^3$ lattice, on which we also compute a latent heat of $\Delta\epsilon\approx 0.6 \epsilon_{SB}$. Computing Polyakov loop correlation functions we calculate the string tension at finite temperature in the confined phase between fundamental charges, $\sigma_1$, between diquark charges, $\sigma_2$, and between adjoint charges $\sigma_4$. We find that $1 < \sigma_2/\sigma_1 < 2$, and our result for the adjoint string tension $\sigma_4$ is consistent with string breaking.Comment: 10 pages with included figures. For version 2: New calculation and discussion of latent heat added; 2 new figures and 1 new table. Typo in abstract corrected for v3. To appear in Physical Review

Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib.

Background: In this retrospective analysis, we explored the prognostic and predictive value of the systemic immune-inflammation index (SII), based on lymphocyte, neutrophil, and platelet counts, at baseline and changes at week 6 during first-line sunitinib in patients with metastatic renal cell cancer (RCC).Results: Patients were stratified into high SII (? 730) and low SII (&lt; 730) groups. SII was associated with objective response, p &lt; 0.0001. The median PFS was 6.3 months (95% CI 5.5–8.9) in patients with SII ? 730 and 18.7 months (95% CI 14.7–22.8) in those with SII &lt; 730, p &lt; 0.0001. The median OS was 43.6 months (95% CI 35.3–52.1) in patients with SII &lt; 730, and 13.5 months (95% CI 9.8–18.5) in those with SII ? 730, p &lt; 0.0001. In multivariate analysis, performance status, IMDC score and SII were able to predict OS (HR = 3.29, HR = 1.71 and HR = 1.79, respectively).Materials and Methods: We included 335 consecutive RCC patients treated with first-line sunitinib. The X-tile 3.6.1 software (Yale University, New Haven, CT) was used for bioinformatic analysis of the data to determine the cutoff value of SII. Progression-free survival (PFS), overall survival (OS) and their 95% confidence interval (95% CI) were estimated by Kaplan-Meier method and compared with logrank test. The impact of SII conversion at week 6 of treatment on PFS and OS was evaluated by Cox regression analyses.Conclusions: The SII and its changes during treatment represent a powerful prognostic indicator of clinical outcome in patients with metastatic RCC

Integrating knowledge on green infrastructure, health and well-being in ageing populations: principles for research and practice

Ageing and urbanisation pose significant challenges for public health and urban planning. Ageing populations are at particular risk from hazards arising from urbanisation processes, some of which are in turn exacerbated by climate change. One approach for mitigating the negative effects of urbanisation on ageing populations is the leveraging of the beneficial effects of urban green infrastructure as a public health intervention in the planning process. We assessed the potential of available theoretical frameworks to provide the context for such leverage. This involved active engagement with academics and practitioners specialising in ageing, green infrastructure and health and well-being through a knowledge-brokering approach. We concluded that an integrated and comprehensive framework on the socio-cultural-ecological determinants of health is lacking. To address this, we present a set of principles for overcoming challenges to knowledge integration when working at the intersection of green infrastructure, ageing, health and well-being. Our findings—and the co-production process used to generate them—have wider significance for trans-disciplinary research into the benefits of the natural environment to human health and well-being as well as other complex and interconnected topics associated with global grand challenges

Advances in chemotherapy and targeted systemic therapies for Urothelial cancer

Systemic chemotherapy for cancer of the urothelial tract is used according to two main strategies. Neoadjuvant or adjuvant treatment combined with surgery and/or radiotherapy is aimed at cure of localised disease whilst treatment for advanced incurable disease allows for improved survival and palliation of symptoms. Cisplatin based combination regimens represent the standard of care in both of these settings and incorporation of gemcitabine has allowed for improvements in tolerability over older drugs. However, despite high objective response rates, impact on survival is modest. Targeted agents are now being incorporated into early phase clinical trials. These exciting new strategies hold promise for improved efficacy but with new challenges regarding toxicity profiles. This review will describe current evidence for the use of systemic chemotherapy for urothelial cancer and the state of the research evidence for use of the newer targeted agents

Human-data interaction in the context of care: Co-designing family civic data interfaces and practices

By storing data about citizens for the purposes of service provision, private and public organizations have disempowered the people they serve, shifting the balance of power toward themselves as data holders. Through three co-production engagements involving families receiving “early help” support from their local authority and support workers involved in supplying this care, we have identified existing data usage practices, explored the impact of those practices upon the supported families, and co-designed new and improved approaches - both technological and practice-based - that are perceived to offer families fairer treatment, greater influence, and to benefit from better decision-making. Our findings show that by applying Human-Data Interaction and giving supported families direct access to see and manipulate their own data, both during and outside of the support engagement, the locus of decision-making could be shifted towards the data subject