841 research outputs found
The Association Between the Long-Term Change in Directly Measured Cardiorespiratory Fitness and Mortality Risk
Introduction: There is a strong inverse association between cardiorespiratory fitness (CRF) and mortality outcomes. This relationship has predominantly been assessed cross-sectionally, however low CRF is a modifiable risk factor, thus assessing this association using a single baseline measure may be sub-optimal. Purpose: To examine the association of the long-term change in CRF, measured using cardiopulmonary exercise testing (CPX) with all-cause and disease-specific mortality.
Methods: Participants included 833 apparently healthy men and women (42.9±10.8 years) who underwent two maximal CPXs, the second CPX being â„ 1 year following the baseline assessment. Participants were followed for 17.7 ± 11.8 years for allcause, cardiovascular disease (CVD), and cancer mortality. Cox-proportional hazard models were performed to determine the association between the change in CRF, computed as visit 1 (V1) peak oxygen consumption (VO2peak (ml·kg-1·min-1)) â visit 2 (V2) VO2peak, and mortality outcomes.
Results: During follow-up, 172 participants died. Overall, the change in CPX-derived CRF was inversely related to all-cause, CVD, and cancer mortality (p\u3c0.05). Each 1 ml·kg-1·min-1 increase was associated with a 10.8, 14.7, and 15.9% reductions in allcause, CVD, and cancer mortality, respectively. The inverse relationship between CRF and all-cause mortality remained significant (p\u3c0.05) when men and women were examined independently, after adjusting for years since first CPX, baseline VO2peak, and age.
Conclusion: Long-term changes in CRF were inversely related to mortality outcomes, and mortality was better predicted by CRF measured at subsequent examination than baseline CRF. These findings support the recent American Heart Association scientific statement advocating CRF as a clinical vital sign that should be assessed routinely in clinical practice, as well as support regular participation in physical activity to maintain adequate CRF levels across the lifespan
Atomistic Theory of Coherent Spin Transfer between Molecularly Bridged Quantum Dots
Time-resolved Faradary rotation experiments have demonstrated coherent
transfer of electron spin between CdSe colloidal quantum dots coupled by
conjugated molecules. We employ here a Green's function approach, using
semi-empirical tight-binding to treat the nanocrystal Hamiltonian and Extended
Huckel theory to treat the linking molecule Hamiltonian, to obtain the coherent
transfer probabilities from atomistic calculations, without the introduction of
any new parameters. Calculations on 1,4-dithiolbenzene and
1,4-dithiolcyclohexane linked nanocrystals agree qualitatively with experiment
and provide support for a previous transfer Hamiltonian model. We find a
striking dependence on the transfer probabilities as a function of nanocrystal
surface site attachment and linking molecule conformation. Additionally, we
predict quantum interference effects in the coherent transfer probabilities for
2,7-dithiolnaphthalene and 2,6-dithiolnaphthalene linking molecules. We suggest
possible experiments based on these results that would test the coherent,
through-molecule transfer mechanism.Comment: 12 pages, 9 figures. Submitted Phys. Rev.
The Association between the Change in Directly Measured Cardiorespiratory Fitness across Time and Mortality Risk
Background: The relationship between cardiorespiratory fitness (CRF) and mortality risk has typically been assessed using a single measurement, though some evidence suggests the change in CRF over time influences risk. This evidence is predominantly based on studies using estimated CRF (CRFe). The strength of this relationship using change in directly measured CRF over time in apparently healthy men and women is not well understood.
Purpose: To examine the association of change in CRF over time, measured using cardiopulmonary exercise testing (CPX), with all-cause and disease-specific mortality and to compare baseline and subsequent CRF measurements as predictors of all-cause mortality.
Methods: Participants included 833 apparently healthy men and women (42.9âŻÂ±âŻ10.8âŻyears) who underwent two maximal CPXs, the second CPX being â„1âŻyear following the baseline assessment (mean 8.6âŻyears, range 1.0 to 40.3âŻyears). Participants were followed for up to 17.7 (SD 11.8)âŻyears for all-cause-, cardiovascular disease- (CVD), and cancer mortality. Cox-proportional hazard models were performed to determine the association between the change in CRF, computed as visit 1 (CPX1) peak oxygen consumption (VO2peak [mL·kgâ1·minâ1]) â visit 2 (CPX2) VO2peak, and mortality outcomes. A Wald-Chi square test of equality was used to compare the strength of CPX1 to CPX2 VO2peak in predicting mortality.
Results: During follow-up, 172 participants died. Overall, the change in CPX-CRF was inversely related to all-cause, CVD, and cancer mortality (pâŻ\u3câŻ0.05). Each 1âŻmL·kgâ1·minâ1 increase was associated with a ~11, 15, and 16% (all pâŻ\u3câŻ0.001) reduction in all-cause, CVD, and cancer mortality, respectively. The inverse relationship between CRF and all-cause mortality was significant (pâŻ\u3câŻ0.05) when men and women were examined independently, after adjusting for years since first CPX, baseline VO2peak, and age. Further, the Wald Chi-square test of equality found CPX2 VO2peak to be a significantly stronger predictor of all-cause mortality than CPX1 VO2peak (pâŻ\u3câŻ0.05).
Conclusion: The change in CRF over time was inversely related to mortality outcomes, and mortality was better predicted by CRF measured at subsequent test than CPX1 CRF. These findings emphasize the importance of adopting lifestyle behaviors that promote CRF, as well as support the need for routine assessment of CRF in clinical practice to better assess risk
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Phototransformation of polycyclic aromatic hydrocarbons into stable, mutagenic components
This report compares the mutagenicity of photochemical products produced by exposure of the polycyclic aromatic hydrocarbons benzo(a)pyrene and 9,10-dimethylanthracene or the aromatic amines 2-aminofluorene, 2-aminoanthracene and 2-aminonaphthalene to sunlight or to ultraviolet light (UVA). 2-Aminofluorene, giving the most active products, was further investigated with respect to the mechanism of photoactivation and the chemical identity of the photochemical products. Screening of HPLC resolved photochemical products demonstrated that the majority of the mutagenicity was localized to one peak - which co-chromatographed with 2-nitrofluorene
Scalability of quantum computation with addressable optical lattices
We make a detailed analysis of error mechanisms, gate fidelity, and
scalability of proposals for quantum computation with neutral atoms in
addressable (large lattice constant) optical lattices. We have identified
possible limits to the size of quantum computations, arising in 3D optical
lattices from current limitations on the ability to perform single qubit gates
in parallel and in 2D lattices from constraints on laser power. Our results
suggest that 3D arrays as large as 100 x 100 x 100 sites (i.e.,
qubits) may be achievable, provided two-qubit gates can be performed with
sufficiently high precision and degree of parallelizability. Parallelizability
of long range interaction-based two-qubit gates is qualitatively compared to
that of collisional gates. Different methods of performing single qubit gates
are compared, and a lower bound of is determined on the
error rate for the error mechanisms affecting Cs in a blue-detuned
lattice with Raman transition-based single qubit gates, given reasonable limits
on experimental parameters.Comment: 17 pages, 5 figures. Accepted for publication in Physical Review
LINVIEW: Incremental View Maintenance for Complex Analytical Queries
Many analytics tasks and machine learning problems can be naturally expressed
by iterative linear algebra programs. In this paper, we study the incremental
view maintenance problem for such complex analytical queries. We develop a
framework, called LINVIEW, for capturing deltas of linear algebra programs and
understanding their computational cost. Linear algebra operations tend to cause
an avalanche effect where even very local changes to the input matrices spread
out and infect all of the intermediate results and the final view, causing
incremental view maintenance to lose its performance benefit over
re-evaluation. We develop techniques based on matrix factorizations to contain
such epidemics of change. As a consequence, our techniques make incremental
view maintenance of linear algebra practical and usually substantially cheaper
than re-evaluation. We show, both analytically and experimentally, the
usefulness of these techniques when applied to standard analytics tasks. Our
evaluation demonstrates the efficiency of LINVIEW in generating parallel
incremental programs that outperform re-evaluation techniques by more than an
order of magnitude.Comment: 14 pages, SIGMO
Cardiorespiratory Fitness and Mortality in Healthy Men and Women
Background There is a well-established inverse relationship between cardiorespiratory fitness (CRF) and mortality. However, this relationship has almost exclusively been studied using estimated CRF. Objectives This study aimed to assess the association of directly measured CRF, obtained using cardiopulmonary exercise (CPX) testing with all-cause, cardiovascular disease (CVD), and cancer mortality in apparently healthy men and women. Methods Participants included 4,137 self-referred apparently healthy adults (2,326 men, 1,811 women; mean age: 42.8 ± 12.2 years) who underwent CPX testing to determine baseline CRF. Participants were followed for 24.2 ± 11.7 years (1.1 to 49.3 years) for mortality. Cox-proportional hazard models were performed to determine the relationship of CRF (ml·kg-1·min-1) and CRF level (low, moderate, and high) with mortality outcomes. Results During follow-up, 727 participants died (524 men, 203 women). CPX-derived CRF was inversely related to all-cause, CVD, and cancer mortality. Low CRF was associated with higher risk for all-cause (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.20 to 3.50), CVD (HR: 2.27; 95% CI: 1.20 to 3.49), and cancer (HR: 2.07; 95% CI: 1.18 to 3.36) mortality compared with high CRF. Further, each metabolic equivalent increment increase in CRF was associated with a 11.6%, 16.1%, and 14.0% reductions in all-cause, CVD, and cancer mortality, respectively. Conclusions Given the prognostic ability of CPX-derived CRF for all-cause and disease-specific mortality outcomes, its use should be highly considered for apparently healthy populations as it may help to improve the efficacy of the individualized patient risk assessment and guide clinical decisions
Effects of harvest season on carcass characteristics of lambs in the Intermountain West
Objective: The objectives of this study were to survey characteristics including hot carcass weight (HCW), 12th rib fat thickness (RFT), body-wall thickness (BWT), longissimus muscle area (LMA), USDA yield grade (USDA YG), percentage closely trimmed retail cuts (RC), and calculated yield grade (Calc YG) of lamb carcasses in the Intermountain West to determine the effects of season of slaughter and interrelationships among carcass characteristics.
Materials and Methods: Lamb carcass characteristics were evaluated in 2 commercial Intermountain West processing plants over one year (n = 10,027). Carcasses were evaluated by season: spring (DecemberâApril, n = 2,322) and summer (MayâAugust, n = 7,705).
Results and Discussion: Carcasses of lambs slaughtered in the spring had 3.4 kg heavier HCW (P = 0.04) than those slaughtered in the summer. Subcutaneous fat (RFT; P = 0.06) and Calc YG (P = 0.09) tended to be greater in the spring than summer. Correlation coefficients and models of fit with a linear covariate of HCW indicated negative relationship between HCW and RC and positive relationship with all other carcass traits (P \u3c 0.001). Overall, graded lamb carcasses exceeded commercial processing plant preferred HCW (38.6 kg) by 5% (mean = 40.5 kg) and industry acceptable RFT (6 mm) by 25% (mean = 8.03 mm). Furthermore, 70% of lamb carcasses exceed 6 mm RFT.
Implications and Applications: Season of slaughter contributed to differences in HCW and USDA YG but no other carcass characteristics. Still, carcass data surveyed from the largest lamb-producing region of the United States suggests that the degree of fatness exceeds industry preferences. Although abattoirs mitigate adverse effects of excessive fat through trimming and diverse market outlets, industry-wide efforts that agree on acceptable standards of trimness are needed. Transparent dialog across industry segments should be prioritized in addition to consistent integration of value-based pricing to reduce the proportion of excessively finished lambs
Whistler mode startup in the Michigan Mirror Machine
Results of investigations of whistler mode ECRH plasma startup in the Michigan Mirror Machine are presented. Electronâvelocityâdistribution and plasmaâspatialâdistribution time evolution are characterized by measurements from axially and radially moveable Langmuir probes, an endloss current detector, an electron cyclotron emission radiometer, a foilâfiltered Xâray detector, and a diamagnetic loop at the mirror midplane. Measurements of the buildup of both electron density and perpendicular pressure (nkTâ) are compared to predictions from various numerical models. Both modeling and data suggest the creation of a highly anisotropic electron velocity distribution function with a ââsloshing electronââ axial density profile.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87352/2/204_1.pd
Quantum dynamics of local phase differences between reservoirs of driven interacting bosons separated by simple aperture arrays
We present a derivation of the effective action for the relative phase of
driven, aperture-coupled reservoirs of weakly-interacting condensed bosons from
a (3+1)-D microscopic model with local U(1) gauge symmetry. We show that
inclusion of local chemical potential and driving velocity fields as a gauge
field allows derivation of the hydrodynamic equations of motion for the driven
macroscopic phase differences across simple aperture arrays. For a single
aperture, the current-phase equation for driven flow contains sinusoidal,
linear, and current-bias contributions. We compute the renormalization group
(RG) beta function of the periodic potential in the effective action for small
tunneling amplitudes and use this to analyze the temperature dependence of the
low-energy current-phase relation, with application to the transition from
linear to sinusoidal current-phase behavior observed in experiments by
Hoskinson et al. \cite{packard} for liquid He driven through nanoaperture
arrays. Extension of the microscopic theory to a two-aperture array shows that
interference between the microscopic tunneling contributions for individual
apertures leads to an effective coupling between apertures which amplifies the
Josephson oscillations in the array. The resulting multi-aperture current-phase
equations are found to be equivalent to a set of equations for coupled pendula,
with microscopically derived couplings.Comment: 16 pages, 5 figures v2: typos corrected, RG phase diagram correcte
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