Using monoclonal antibodies to prevent mucosal transmission of epidemic infectious diseases.

Passive immunization with antibodies has been shown to prevent a wide variety of diseases. Recent advances in monoclonal antibody technology are enabling the development of new methods for passive immunization of mucosal surfaces. Human monoclonal antibodies, produced rapidly, inexpensively, and in large quantities, may help prevent respiratory, diarrheal, and sexually transmitted diseases on a public health scale

Ohmic and step noise from a single trapping center hybridized with a Fermi sea

We show that single electron tunneling devices such as the Cooper-pair box or double quantum dot can be sensitive to the zero-point fluctuation of a single trapping center hybridized with a Fermi sea. If the trap energy level is close to the Fermi sea and has line-width \gamma > k_B T, its noise spectrum has an Ohmic Johnson-Nyquist form, whereas for \gamma < k_B T the noise has a Lorentzian form expected from the semiclassical limit. Trap levels above the Fermi level are shown to lead to steps in the noise spectrum that can be used to probe their energetics, allowing the identification of individual trapping centers coupled to the device.Comment: Revised version to appear in Phys. Rev. Let

Restoring native ecosystems in urban Auckland: urban soils, isolation, and weeds as impediments to forest establishment

New Zealand urban environments are currently dominated by exotic plant species. Restoring native vegetation and its associated native biodiversity in these landscapes is desirable for both cultural and ecological reasons. We report on the first four years of an ongoing vegetation restoration experiment in Waitakere City, Auckland, that addresses four challenges to urban restoration: weeds, Anthropic Soils, attraction of frugivorous birds, and patch isolation. Nine commonly planted native species, grouped separately into wind- and bird-dispersed species, were planted across four sites increasingly isolated from native bush patches, using two site preparation methods. By year three, woody weeds >50 cm tall had established with an average density of 1.7 plant m across all sites. This was more than 17 times denser than all established wild native woody seedlings of any height. One of our establishment methods, sparse planting with mulch, resulted in higher native plant survival and faster plant growth. However, after 4 years, the more intensive method, dense planting and ripping of the soil, resulted in a denser canopy and a 2.8-fold reduction in woody weed establishment. The typically urban soils of all sites were highly modified, with substantial variation in compaction, ponding risk, and fertility over distances of 5-15 m. Several, but not all, species were detrimentally affected by soil compaction and ponding. Many bird-dispersed species, both native and non-native, colonised the experiment, although this did not differ between plots with planted wind-dispersed and bird-dispersed species, perhaps due to the small size of these plots. Site colonisation by native species was particularly high at sites ≤ 100 m from existing native vegetation, suggesting that even small patches of native vegetation in urban landscapes will be valuable as seed sources for accelerating native plant establishment at nearby receptive sites © New Zealand Ecological Society

Electrical activation and electron spin coherence of ultra low dose antimony implants in silicon

We implanted ultra low doses (2x10^11 cm-2) of 121Sb ions into isotopically enriched 28Si and find high degrees of electrical activation and low levels of dopant diffusion after rapid thermal annealing. Pulsed Electron Spin Resonance shows that spin echo decay is sensitive to the dopant depths, and the interface quality. At 5.2 K, a spin decoherence time, T2, of 0.3 ms is found for profiles peaking 50 nm below a Si/SiO2 interface, increasing to 0.75 ms when the surface is passivated with hydrogen. These measurements provide benchmark data for the development of devices in which quantum information is encoded in donor electron spins

Electronic structure of superposition states in flux qubits

Flux qubits, small superconducting loops interrupted by Josephson junctions, are successful realizations of quantum coherence for macroscopic variables. Superconductivity in these loops is carried by $\sim 10^6$ -- $10^{10}$ electrons, which has been interpreted as suggesting that coherent superpositions of such current states are macroscopic superpositions analogous to Schr\"odinger's cat. We provide a full microscopic analysis of such qubits, from which the macroscopic quantum description can be derived. This reveals that the number of microscopic constituents participating in superposition states for experimentally accessible flux qubits is surprisingly but not trivially small. The combination of this relatively small size with large differences between macroscopic observables in the two branches is seen to result from the Fermi statistics of the electrons and the large disparity between the values of superfluid and Fermi velocity in these systems.Comment: Minor cosmetic changes. Published version

Autotuning Algorithmic Choice for Input Sensitivity

Empirical autotuning is increasingly being used in many domains to achieve optimized performance in a variety of different execution environments. A daunting challenge faced by such autotuners is input sensitivity, where the best autotuned configuration may vary with different input sets. In this paper, we propose a two level solution that: first, clusters to find input sets that are similar in input feature space; then, uses an evolutionary autotuner to build an optimized program for each of these clusters; and, finally, builds an adaptive overhead aware classifier which assigns each input to a specific input optimized program. Our approach addresses the complex trade-off between using expensive features, to accurately characterize an input, and cheaper features, which can be computed with less overhead. Experimental results show that by adapting to different inputs one can obtain up to a 3x speedup over using a single configuration for all inputs

Long-range energy transport in photosystem II.

We simulate the long-range inter-complex electronic energy transfer in photosystem II-from the antenna complex, via a core complex, to the reaction center-using a non-Markovian (ZOFE) quantum master equation description that allows the electronic coherence involved in the energy transfer to be explicitly included at all length scales. This allows us to identify all locations where coherence is manifested and to further identify the pathways of the energy transfer in the full network of coupled chromophores using a description based on excitation probability currents. We investigate how the energy transfer depends on the initial excitation-localized, coherent initial excitation versus delocalized, incoherent initial excitation-and find that the overall energy transfer is remarkably robust with respect to such strong variations of the initial condition. To explore the importance of vibrationally enhanced transfer and to address the question of optimization in the system parameters, we systematically vary the strength of the coupling between the electronic and the vibrational degrees of freedom. We find that the natural parameters lie in a (broad) region that enables optimal transfer efficiency and that the overall long-range energy transfer on a ns time scale appears to be very robust with respect to variations in the vibronic coupling of up to an order of magnitude. Nevertheless, vibrationally enhanced transfer appears to be crucial to obtain a high transfer efficiency, with the latter falling sharply for couplings outside the optimal range. Comparison of our full quantum simulations to results obtained with a "classical" rate equation based on a modified-Redfield/generalized-Förster description previously used to simulate energy transfer dynamics in the entire photosystem II complex shows good agreement for the overall time scales of excitation energy transport

Differences in long-term physical activity trajectories among individuals with chronic widespread pain : A secondary analysis of a randomized controlled trial

Funding Sources: The MUSICIAN trial was funded by Arthritis Research UK, Chesterfield, UK (Grant award number 17292) and the MELODIC study was funded by NHS Grampian Endowment Grant, Project No: 14/40.Peer reviewedPostprin