Applying a Cut-Based Data Reduction Rule for Weighted Cluster Editing in Polynomial Time

Given an undirected graph, the task in Cluster Editing is to insert and delete a minimum number of edges to obtain a cluster graph, that is, a disjoint union of cliques. In the weighted variant each vertex pair comes with a weight and the edge modifications have to be of minimum overall weight. In this work, we provide the first polynomial-time algorithm to apply the following data reduction rule of Böcker et al. [Algorithmica, 2011] for Weighted Cluster Editing: For a graph $G = (V,E)$, merge a vertex set $S ⊆ V$ into a single vertex if the minimum cut of G[S] is at least the combined cost of inserting all missing edges within G[S] plus the cost of cutting all edges from S to the rest of the graph. Complementing our theoretical findings, we experimentally demonstrate the effectiveness of the data reduction rule, shrinking real-world test instances from the PACE Challenge 2021 by around 24% while previous heuristic implementations of the data reduction rule only achieve 8%

A diagnosis of mycosis fungoides in a pediatric patient with recurrent Langerhans cell histiocytosis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141250/1/pbc26835.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141250/2/pbc26835_am.pd

Emicizumab prophylaxis to facilitate anticoagulant therapy for management of intra‐atrial thrombosis in severe haemophilia with an inhibitor

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149546/1/hae13721.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149546/2/hae13721_am.pd

PD‐1 inhibition in congenital pigment synthesizing metastatic melanoma

A newborn female child was born with a congenital pigment synthesizing melanoma of the scalp. Further workup revealed metastatic disease within the liver, lungs, and left tibia. Whole exome sequencing was performed on multiple samples that revealed one somatic mutation, lysine methyltransferase 2C (KMT2C), at low allelic frequency but no v‐Raf murine sarcoma viral oncogene homolog B (BRAF), NF‐1 mutation. Programmed death ligand 1 was moderately expressed. Treatment was initiated with the programmed cell death protein 1 inhibitor nivolumab. The patient tolerated this treatment well with minimal toxicity. She is now over a year out from initial diagnosis, continuing on nivolumab, with stable disease.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139985/1/pbc26702.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139985/2/pbc26702_am.pd

Phase locking and resetting in human subthalamic neurons

Article accompanying a poster presentation for the 2012 Computational Neuroscience Annual Meeting. This article discusses the derivation of the evolution of empathic other-regarding social emotions as compared to non-social self-regarding emotions

Advantage of recombinant von Willebrand factor for peri‐operative management in paediatric acquired von Willebrand syndrome

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144273/1/hae13436_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144273/2/hae13436.pd

On-farm Campylobacter and Escherichia coli in commercial broiler chickens: Re-used bedding does not influence Campylobacter emergence and levels across sequential farming cycles

Limitations in quality bedding material have resulted in the growing need to re-use litter during broiler farming in some countries, which can be of concern from a food-safety perspective. The aim of this study was to compare the Campylobacter levels in ceca and litter across three litter treatments under commercial farming conditions. The litter treatments were (a) the use of new litter after each farming cycle; (b) an Australian partial litter re-use practice; and (c) a full litter re-use practice. The study was carried out on two farms over two years (Farm 1, from 2009–2010 and Farm 2, from 2010–2011), across three sheds (35,000 to 40,000 chickens/shed) on each farm, adopting three different litter treatments across six commercial cycles. A random sampling design was adopted to test litter and ceca for Campylobacter and Escherichia coli, prior to commercial first thin-out and final pick-up. Campylobacter levels varied little across litter practices and farming cycles on each farm and were in the range of log 8.0–9.0 CFU/g in ceca and log 4.0–6.0 MPN/g for litter. Similarly the E. coli in ceca were ∼log 7.0 CFU/g. At first thin-out and final pick-up, the statistical analysis for both litter and ceca showed that the three-way interaction (treatments by farms by times) was highly significant (P < 0.01), indicating that the patterns of Campylobacter emergence/presence across time vary between the farms, cycles and pickups. The emergence and levels of both organisms were not influenced by litter treatments across the six farming cycles on both farms. Either C. jejuni or C. coli could be the dominant species across litter and ceca, and this phenomenon could not be attributed to specific litter treatments. Irrespective of the litter treatments in place, cycle 2 on Farm 2 remained campylobacter-free. These outcomes suggest that litter treatments did not directly influence the time of emergence and levels of Campylobacter and E. coli during commercial farming

On-farm Campylobacter and Escherichia coli in commercial broiler chickens: Re-used bedding does not influence Campylobacter emergence and levels across sequential farming cycles

Limitations in quality bedding material have resulted in the growing need to re-use litter during broiler farming in some countries, which can be of concern from a food-safety perspective. The aim of this study was to compare the Campylobacter levels in ceca and litter across three litter treatments under commercial farming conditions. The litter treatments were (a) the use of new litter after each farming cycle; (b) an Australian partial litter re-use practice; and (c) a full litter re-use practice. The study was carried out on two farms over two years (Farm 1, from 2009–2010 and Farm 2, from 2010–2011), across three sheds (35,000 to 40,000 chickens/shed) on each farm, adopting three different litter treatments across six commercial cycles. A random sampling design was adopted to test litter and ceca for Campylobacter and Escherichia coli, prior to commercial first thin-out and final pick-up. Campylobacter levels varied little across litter practices and farming cycles on each farm and were in the range of log 8.0–9.0 CFU/g in ceca and log 4.0–6.0 MPN/g for litter. Similarly the E. coli in ceca were ∼log 7.0 CFU/g. At first thin-out and final pick-up, the statistical analysis for both litter and ceca showed that the three-way interaction (treatments by farms by times) was highly significant (P < 0.01), indicating that the patterns of Campylobacter emergence/presence across time vary between the farms, cycles and pickups. The emergence and levels of both organisms were not influenced by litter treatments across the six farming cycles on both farms. Either C. jejuni or C. coli could be the dominant species across litter and ceca, and this phenomenon could not be attributed to specific litter treatments. Irrespective of the litter treatments in place, cycle 2 on Farm 2 remained campylobacter-free. These outcomes suggest that litter treatments did not directly influence the time of emergence and levels of Campylobacter and E. coli during commercial farming

An Investigation into the Measurement and Prediction of Mechanical Stiffness of Lower-limb Prostheses used for Running

Two energy return prosthesis are subjected to three different statically applied loading methods. This initial study proposes that statically applied loading to a sport prosthesis using several controlled methods were statistically robust enough to derive a mechanical stiffness value. However, any predicted stiffness is drawn into question when allowing any movement of the distal end. This uncertainty will make any evaluation or prescription of lower-limb prosthesis technology based upon their stiffness incorrect. In addition, the peak calculated stiffness at the expected bodyweight induced ground impact load of a runner is judged the most representative assessment method. This study attempts to build on previous research advocating the need to monitor the performance of prosthesis lower-limb technology in disability sport. Practitioner Summary: This paper extends previous research regarding the fairness of prosthetics technology used in running with a lower-limb amputation. It pilots a quantitative assessment of high activity prosthetics technology and ultimately demonstrates how incorrect assessment can lead to incorrect specification of running prosthesis for elite level spor

Tissue and serum markers of inflammation during the follow-up of patients with giant-cell arteritis—a prospective longitudinal study

Objective. To evaluate the association between inflammatory markers and relapse in GCA patients longitudinally assessed in a clinical trial of infliximab and glucocorticosteroids