475 research outputs found
Progress with variable cycle engines
The evaluation of components of an advanced propulsion system for a future supersonic cruise vehicle is discussed. These components, a high performance duct burner for thrust augmentation and a low jet noise coannular exhaust nozzle, are part of the variable stream control engine. An experimental test program involving both isolated component and complete engine tests was conducted for the high performance, low emissions duct burner with excellent results. Nozzle model tests were completed which substantiate the inherent jet noise benefit associated with the unique velocity profile possible of a coannular exhaust nozzle system on a variable stream control engine. Additional nozzle model performance tests have established high thrust efficiency levels at takeoff and supersonic cruise for this nozzle system. Large scale testing of these two critical components is conducted using an F100 engine as the testbed for simulating the variable stream control engine
Variable Cycle Engine Technology Program Planning and Definition Study
The variable stream control engine, VSCE-502B, was selected as the base engine, with the inverted flow engine concept selected as a backup. Critical component technologies were identified, and technology programs were formulated. Several engine configurations were defined on a preliminary basis to serve as demonstration vehicles for the various technologies. The different configurations present compromises in cost, technical risk, and technology return. Plans for possible variably cycle engine technology programs were formulated by synthesizing the technology requirements with the different demonstrator configurations
Quantum mutual information and the one-time pad
Alice and Bob share a correlated composite quantum system AB. If AB is used
as the key for a one-time pad cryptographic system, we show that the maximum
amount of information that Alice can send securely to Bob is the quantum mutual
information of AB.Comment: 11 pages, LaTe
Entanglement on mixed stabilizer states: normal forms and reduction procedures
Published versio
On asymptotic continuity of functions of quantum states
A useful kind of continuity of quantum states functions in asymptotic regime
is so-called asymptotic continuity. In this paper we provide general tools for
checking if a function possesses this property. First we prove equivalence of
asymptotic continuity with so-called it robustness under admixture. This allows
us to show that relative entropy distance from a convex set including maximally
mixed state is asymptotically continuous. Subsequently, we consider it arrowing
- a way of building a new function out of a given one. The procedure originates
from constructions of intrinsic information and entanglement of formation. We
show that arrowing preserves asymptotic continuity for a class of functions
(so-called subextensive ones). The result is illustrated by means of several
examples.Comment: Minor corrections, version submitted for publicatio
Registrar wellness in Botswana: Measuring burnout and identifying ways to improve wellness
Background. Burnout during registrar training is high, especially in resource-limited settings where stressors are intensified. Burnout leads to decreased quality of life for doctors, poor job and patient satisfaction, and difficulty retaining doctors.Objectives. Primary: to measure burnout among registrars working at Princess Marina Hospital in Gaborone, Botswana. Secondary: to determine factors contributing to burnout and identify potential wellness interventions.Methods. The validated Maslach Burnout Inventory was used to measure the degree of emotional exhaustion, depersonalisation and personal accomplishment. Work-related difficulties and potential wellness interventions were explored through multiple-choice and open-ended questions.Results. Of 40 eligible registrars, 20 (50%) completed the survey. High levels of burnout were reported for emotional exhaustion in 65% (13/20), depersonalisation in 45% (9/20), and personal accomplishment in 35% (7/20) of registrars. A high degree of burnout was reported by 75% (15/20) of registrars in one or more domains. In the previous 7 days, registrars worked an average of 77 hours, took 1.5 overnight calls, slept 5.7 hours per night, and 53% (10/19) had ≥1 of their patients die. Five (25%) registrars considered leaving Botswana to work in another country, which correlated with those with the highest degree of burnout. The most common frustrations included insufficient salary and limited medical resources. Suggested interventions included improved mentorship and wellness lectures.Conclusions. There is a high degree of burnout, especially emotional exhaustion, among registrars. Encouragingly, most registrars have a desire to work in Botswana after training. Future research on improving registrar wellness in low-resource settings is urgently needed
Additivity and non-additivity of multipartite entanglement measures
We study the additivity property of three multipartite entanglement measures,
i.e. the geometric measure of entanglement (GM), the relative entropy of
entanglement and the logarithmic global robustness. First, we show the
additivity of GM of multipartite states with real and non-negative entries in
the computational basis. Many states of experimental and theoretical interests
have this property, e.g. Bell diagonal states, maximally correlated generalized
Bell diagonal states, generalized Dicke states, the Smolin state, and the
generalization of D\"{u}r's multipartite bound entangled states. We also prove
the additivity of other two measures for some of these examples. Second, we
show the non-additivity of GM of all antisymmetric states of three or more
parties, and provide a unified explanation of the non-additivity of the three
measures of the antisymmetric projector states. In particular, we derive
analytical formulae of the three measures of one copy and two copies of the
antisymmetric projector states respectively. Third, we show, with a statistical
approach, that almost all multipartite pure states with sufficiently large
number of parties are nearly maximally entangled with respect to GM and
relative entropy of entanglement. However, their GM is not strong additive;
what's more surprising, for generic pure states with real entries in the
computational basis, GM of one copy and two copies, respectively, are almost
equal. Hence, more states may be suitable for universal quantum computation, if
measurements can be performed on two copies of the resource states. We also
show that almost all multipartite pure states cannot be produced reversibly
with the combination multipartite GHZ states under asymptotic LOCC, unless
relative entropy of entanglement is non-additive for generic multipartite pure
states.Comment: 45 pages, 4 figures. Proposition 23 and Theorem 24 are revised by
correcting a minor error from Eq. (A.2), (A.3) and (A.4) in the published
version. The abstract, introduction, and summary are also revised. All other
conclusions are unchange
Comparative Genome-Wide Screening Identifies a Conserved Doxorubicin Repair Network That Is Diploid Specific in Saccharomyces cerevisiae
The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB) damage. In order to identify conserved genes that mediate DOX resistance, we screened the Saccharomyces cerevisiae diploid deletion collection and identified 376 deletion strains in which exposure to DOX was lethal or severely reduced growth fitness. This diploid screen identified 5-fold more DOX resistance genes than a comparable screen using the isogenic haploid derivative. Since DSB damage is repaired primarily by homologous recombination in yeast, and haploid cells lack an available DNA homolog in G1 and early S phase, this suggests that our diploid screen may have detected the loss of repair functions in G1 or early S phase prior to complete DNA replication. To test this, we compared the relative DOX sensitivity of 30 diploid deletion mutants identified under our screening conditions to their isogenic haploid counterpart, most of which (n = 26) were not detected in the haploid screen. For six mutants (bem1Δ, ctf4Δ, ctk1Δ, hfi1Δ,nup133Δ, tho2Δ) DOX-induced lethality was absent or greatly reduced in the haploid as compared to the isogenic diploid derivative. Moreover, unlike WT, all six diploid mutants displayed severe G1/S phase cell cycle progression defects when exposed to DOX and some were significantly enhanced (ctk1Δ and hfi1Δ) or deficient (tho2Δ) for recombination. Using these and other “THO2-like” hypo-recombinogenic, diploid-specific DOX sensitive mutants (mft1Δ, thp1Δ, thp2Δ) we utilized known genetic/proteomic interactions to construct an interactive functional genomic network which predicted additional DOX resistance genes not detected in the primary screen. Most (76%) of the DOX resistance genes detected in this diploid yeast screen are evolutionarily conserved suggesting the human orthologs are candidates for mediating DOX resistance by impacting on checkpoint and recombination functions in G1 and/or early S phases
Spin and Rotations in Galois Field Quantum Mechanics
We discuss the properties of Galois Field Quantum Mechanics constructed on a
vector space over the finite Galois field GF(q). In particular, we look at
2-level systems analogous to spin, and discuss how SO(3) rotations could be
embodied in such a system. We also consider two-particle `spin' correlations
and show that the Clauser-Horne-Shimony-Holt (CHSH) inequality is nonetheless
not violated in this model.Comment: 21 pages, 11 pdf figures, LaTeX. Uses iopart.cls. Revised
introduction. Additional reference
Update on pathology laboratory development and research in advancing regional cancer care in Malawi
The pathology laboratory at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi was established in 2011. We published our initial experiences in laboratory development and telepathology in 2013 and 2016, respectively. The purpose of this paper is to provide an update on our work by highlighting the positive role laboratory development has played in improving regional cancer care and research. In addition, we provide a summary of the adult pathology data from specimens received between July 1, 2011, and May 31, 2019, with an emphasis on malignant diagnoses. We compare these summaries to estimates of cancer incidence in this region to identify gaps and future needs
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