Excretion of amino acids by patients with psoriasis ingesting two levels of the same protein

The amounts of 27 amino acids and other ninhydrin-reacting substances were determined by ion-exchange chromatography in the urine of patients with psoriasis, eating diets containing 54 and 104 Gm. of protein from the same source. Regardless of level of protein intake, asparagine plus glutamine, histidine, glycine, and taurine or lysine contents of urine accounted for between 55 and 64 per cent of the total amount of amino acids present. This nucleus of amino acids, with the exception of lysine, was the same as in control individuals fed the same diets. The amount of amino acids in the urine increased when the protein intake was doubled, but only lysine, [alpha]-aminoadipic acid, and cystathionine excretion was increased at least twofold. No outstanding differences in amino acid excretion were found between patients with psoriasis and control subjects.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33493/1/0000899.pd

A quantitative automated technique for the determination of diazotizable imidazole compounds in biological material

A quantitative automated apparatus is described for the simultaneous determination of a number of diazotizable imidazole compounds in the same sample of biological material. Its use in the analysis of urine, plasma and extracts of body tissues is illustrated., In practice, the biological fluid or tissue extract is applied to an ion-exchange column adn a buffer gradient of increasing pH and ionic strength is used to separate the various imidazole compounds. The resulting eluate automatically is made alkaline, diazotized, and the color produced is determined by continous photometry. The results are plotted automatically on a recording microammeter.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33500/1/0000906.pd

Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies

Contains fulltext : 117896.pdf (publisher's version ) (Closed access)BACKGROUND: Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association between tubal ligation and ovarian cancer subtypes. METHODS: We pooled primary data from 13 population-based case-control studies, including 10 157 patients with ovarian cancer (7942 invasive; 2215 borderline) and 13 904 control women. Invasive cases were analysed by histological type, grade and stage, and borderline cases were analysed by histological type. Pooled odds ratios were estimated using conditional logistic regression to match on site, race/ethnicity and age categories, and to adjust for age, oral contraceptive use duration and number of full-term births. RESULTS: Tubal ligation was associated with significantly reduced risks of invasive serous (OR, 0.81; 95% CI, 0.74-0.89; P < 0.001), endometrioid (OR, 0.48; 95% CI, 0.40-0.59; P < 0.001), clear cell (OR, 0.52; 95% CI, 0.40-0.67; P < 0.001) and mucinous (OR, 0.68; 95% CI, 0.52-0.89; P = 0.005) cancers. The magnitude of risk reduction was significantly greater for invasive endometrioid (P < 0.0001) and clear cell (P = 0.0018) than for serous cancer. No significant associations were found with borderline serous or mucinous tumours. CONCLUSIONS: We found that the protective effects of tubal ligation on ovarian cancer risk were subtype-specific. These findings provide insights into distinct aetiologies of ovarian cancer subtypes and mechanisms underlying the protective effects of tubal ligation

Teaching Bioeconomics

Bioeconomics is a relatively young field that uses an expanded microeconomics to examine animal behavior, human behavior, and animal and human social institutions. A voluminous literature is rapidly accumulating. There are as yet no standard textbooks, but there are several excellent books and/or articles that can be used in combination with videos and other aids to make a course that students will enjoy and that teachers can use to advance the frontiers of scholarship in economics and biology. Copyright Springer 2005altruism, conflict, cooperation, evolution, game theory, institutions, rationality,