A method for nitric oxide radical scavenging properties of sulfur containing compounds.

A new method for the quantification of the nitric oxide (NO) scavenging activity of compounds in aqueous solutions is described using an amperometric NO sensor. After correction for the spontaneous degradation of NO, second-order rate kinetics of the scavenging reaction are observed. The rate constant for haemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable NO scavenging activity

Profiles of vocalization change in children with autism receiving early intervention

Abstract not availableDavid Trembath, Marleen F. Westerveld, Srinivas Teppala, Abirami Thirumanickam, Rhylee Sulek, Veronica Rose, Madonna Tucker, Jessica Paynter, Orit Hetzroni, Deb Keen, and Giacomo Vivant

Spoken Language Change in Children on the Autism Spectrum Receiving Community-Based Interventions

OnlinePublWe assessed the spoken language of 73 preschool aged children on the autism spectrum receiving community-based early intervention at two time points, approximately 7 months apart. Using the Spoken Language Benchmarks, there was a small non-signifcant change in the proportion of children transitioning from below, to at or above, Phase 3 (word combinations). Using binomial regression, a model comprising seven of nine clinician-proposed child-related predictors explained 64% of the variance. None of the predictors were individually signifcant, although a large efect size (OR=16.71) was observed for children’s baseline rate of communicative acts. The fndings point to substantial unmet clinical need in children with minimal verbal language, but also the relevance of clinician-proposed predictors of their spoken language outcomes.David Trembath, Matt Stainer, Teena Caithness, Cheryl Dissanayake, Valsamma Eapen, Kathryn Fordyce, Veronica Frewer, Grace Frost, Kristelle Hudry, Teresa Iacono, Nicole Mahler, Anne Masi, Jessica Paynter, Katherine Pye, Shannon Quan, Leanne Shellshear, Rebecca Sutherland, Stephanie Sievers, Abirami Thirumanickam, Marleen F. Westerveld, Madonna Tucke