85 research outputs found
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The importance of particle size distribution and internal structure for triple-frequency radar retrievals of the morphology of snow
The accurate representation of ice particles is essential for both remotely sensed estimates of clouds and precipitation and numerical models of the atmosphere. As it is typical in radar retrievals to assume that all snow is composed of aggregate snowflakes, both denser rimed snow and the mixed-phase cloud in which riming occurs may be under-diagnosed in retrievals and therefore difficult to evaluate in weather and climate models. Recent experimental and numerical studies have yielded methods for using triple-frequency radar measurements to interrogate the internal structure of aggregate snowflakes and to distinguish more dense and homogeneous rimed particles from aggregates. In this study we investigate which parameters of the morphology and size distribution of ice particles most affect the triple-frequency radar signature and must therefore be accounted for in order to carry out triple-frequency radar retrievals of snow. A range of ice particle morphologies are represented, using a fractal representation for the internal structure of aggregate snowflakes and homogeneous spheroids to represent graupel-like particles; the mass-size and area-size relations are modulated by a density factor. We find that the particle size distribution (PSD) shape parameter and the parameters controlling the internal structure of aggregate snowflakes both have significant influences on triple-frequency radar signature and are at least as important as that of the density factor. We explore how these parameters may be allowed to vary in order to prevent triple-frequency radar retrievals of snow from being over-constrained, using two case studies from the Biogenic Aerosols - Effects of Clouds and Climate (BAECC) 2014 field campaign at Hyytiala, Finland. In a case including heavily rimed snow followed by large aggregate snowflakes, we show that triple-frequency radar measurements provide a strong constraint on the PSD shape parameter, which can be estimated from an ensemble of retrievals; however, resolving variations in the PSD shape parameter has a limited impact on estimates of snowfall rate from radar. Particle density is more effectively constrained by the Doppler velocity than triple-frequency radar measurements, due to the strong dependence of particle fall speed on density. Due to the characteristic signatures of aggregate snowflakes, a third radar frequency is essential for effectively constraining the size of large aggregates. In a case featuring rime splintering, differences in the internal structures of aggregate snowflakes are revealed in the triple-frequency radar measurements. We compare retrievals assuming different aggregate snowflake models against in situ measurements at the surface and show significant uncertainties in radar retrievals of snow rate due to changes in the internal structure of aggregates. The importance of the PSD shape parameter and snowflake internal structure to triple-frequency radar retrievals of snow highlights that the processes by which ice particles interact may need to be better understood and parameterized before triple-frequency radar measurements can be used to constrain retrievals of ice particle morphology.Peer reviewe
Composite structural motifs of binding sites for delineating biological functions of proteins
Most biological processes are described as a series of interactions between
proteins and other molecules, and interactions are in turn described in terms
of atomic structures. To annotate protein functions as sets of interaction
states at atomic resolution, and thereby to better understand the relation
between protein interactions and biological functions, we conducted exhaustive
all-against-all atomic structure comparisons of all known binding sites for
ligands including small molecules, proteins and nucleic acids, and identified
recurring elementary motifs. By integrating the elementary motifs associated
with each subunit, we defined composite motifs which represent
context-dependent combinations of elementary motifs. It is demonstrated that
function similarity can be better inferred from composite motif similarity
compared to the similarity of protein sequences or of individual binding sites.
By integrating the composite motifs associated with each protein function, we
define meta-composite motifs each of which is regarded as a time-independent
diagrammatic representation of a biological process. It is shown that
meta-composite motifs provide richer annotations of biological processes than
sequence clusters. The present results serve as a basis for bridging atomic
structures to higher-order biological phenomena by classification and
integration of binding site structures.Comment: 34 pages, 7 figure
Development of the Low Frequency Telescope Focal Plane Detector Modules for LiteBIRD
LiteBIRD is a JAXA-led strategic large-class satellite mission designed to
measure the polarization of the cosmic microwave background and Galactic
foregrounds from 34 to 448 GHz across the entire sky from L2 in the late 2020s.
The scientific payload includes three telescopes which are called the low-,
mid-, and high-frequency telescopes each with their own receiver that covers a
portion of the mission's frequency range. The low frequency telescope will map
synchrotron radiation from the Galactic foreground and the cosmic microwave
background. We discuss the design, fabrication, and characterization of the
low-frequency focal plane modules for low-frequency telescope, which has a
total bandwidth ranging from 34 to 161 GHz. There will be a total of 4
different pixel types with 8 overlapping bands to cover the full frequency
range. These modules are housed in a single low-frequency focal plane unit
which provides thermal isolation, mechanical support, and radiative baffling
for the detectors. The module design implements multi-chroic lenslet-coupled
sinuous antenna arrays coupled to transition edge sensor bolometers read out
with frequency-domain mulitplexing. While this technology has strong heritage
in ground-based cosmic microwave background experiments, the broad frequency
coverage, low optical loading conditions, and the high cosmic ray background of
the space environment require further development of this technology to be
suitable for LiteBIRD. In these proceedings, we discuss the optical and
bolometeric characterization of a triplexing prototype pixel with bands
centered on 78, 100, and 140 GHz.Comment: SPIE Astronomical Telescope + Instrumentation (AS22
The Simons Observatory Large Aperture Telescope Receiver
The Simons Observatory (SO) Large Aperture Telescope Receiver (LATR) will be
coupled to the Large Aperture Telescope located at an elevation of 5,200 m on
Cerro Toco in Chile. The resulting instrument will produce arcminute-resolution
millimeter-wave maps of half the sky with unprecedented precision. The LATR is
the largest cryogenic millimeter-wave camera built to date with a diameter of
2.4 m and a length of 2.6 m. It cools 1200 kg of material to 4 K and 200 kg to
100 mk, the operating temperature of the bolometric detectors with bands
centered around 27, 39, 93, 145, 225, and 280 GHz. Ultimately, the LATR will
accommodate 13 40 cm diameter optics tubes, each with three detector wafers and
a total of 62,000 detectors. The LATR design must simultaneously maintain the
optical alignment of the system, control stray light, provide cryogenic
isolation, limit thermal gradients, and minimize the time to cool the system
from room temperature to 100 mK. The interplay between these competing factors
poses unique challenges. We discuss the trade studies involved with the design,
the final optimization, the construction, and ultimate performance of the
system
The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods
The Protein Structure Initiative’s Structural Biology Knowledgebase (SBKB, URL: http://sbkb.org) is an open web resource designed to turn the products of the structural genomics and structural biology efforts into knowledge that can be used by the biological community to understand living systems and disease. Here we will present examples on how to use the SBKB to enable biological research. For example, a protein sequence or Protein Data Bank (PDB) structure ID search will provide a list of related protein structures in the PDB, associated biological descriptions (annotations), homology models, structural genomics protein target status, experimental protocols, and the ability to order available DNA clones from the PSI:Biology-Materials Repository. A text search will find publication and technology reports resulting from the PSI’s high-throughput research efforts. Web tools that aid in research, including a system that accepts protein structure requests from the community, will also be described. Created in collaboration with the Nature Publishing Group, the Structural Biology Knowledgebase monthly update also provides a research library, editorials about new research advances, news, and an events calendar to present a broader view of structural genomics and structural biology
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