2,114 research outputs found

    Consensus-Based Assessment for Re-envisioning a Reference Collection

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    Moving Through the Rocky Legal Terrain to Find a Safe Royalty Clause or a New Market at the Well

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    This Article will explore whether re-emergence of a market at the wellhead is legally viable considering judicial rulings related to the issue and specifically, whether such a development would be held to run afoul of the implied covenant to market. This Article will review the law of each state with potential for developing Marcellus and Utica Shale gas, while keeping in mind that some states have no law on the issue, again creating uncertainty because of the divergent rulings by other states\u27 courts. Finally, this Article will discuss the merits of completely abandoning the at the well approach to valuation for purposes of royalty calculation in new leases as the preferred way of avoiding litigation over this issue

    Human saliva as a source of anti-malarial antibodies to examine population exposure to Plasmodium falciparum

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    BACKGROUND: Antibody responses to malaria antigens reflect exposure to parasites, and seroprevalence correlates with malaria transmission intensity. Antibodies are routinely measured in sera or on dried blood spots but a non-invasive method would provide extra utility in sampling general populations. Saliva is already in use in the detection of plasma-derived IgM and IgG to viral infections. In this study, antibodies to Plasmodium falciparum merozoite antigens were compared between blood and saliva samples from the same individuals in unlinked surveys conducted in Tanzania and The Gambia. METHODS: In Tanzania, 53 individuals provided paired fingerprick blood and saliva sample using two commercially available sampling devices. In the Gambia, archived plasma and saliva samples collected from 200 children in the Farafenni area in a cross-sectional survey were analyzed.IgG antibodies against P. falciparum antigens, Merozoite Surface Protein-1 (MSP-119) and Apical membrane Antigen (AMA-1) were measured by ELISA in paired saliva and blood samples from both sites. Antibody levels were compared as continuous optical density (OD) values and by sero-positivity. RESULTS: Significant correlations between saliva and plasma antibody levels were seen in Tanzania for both antigens, AMA-1(r2 range 0.93 to 0.89, p < 0.001) and MSP-119 (r2 range 0.93 to 0.75, p < 0.001), with a weaker correlation for results from The Gambia (r2range 0.64 to 0.63, p < 0.01). When assessed as seropositivity and compared with plasma, sensitivity and specificity were good with saliva antibody levels to both AMA-1 and MSP-1(19) (sensitivity range 64-77% and specificity range 91-100% & 47-67% and 90-97% respectively) over the different sample sets. CONCLUSIONS: These data demonstrate anti-malarial antibodies can be detected in saliva and correlate strongly with levels in plasma. This non-invasive relatively simple collection method will be potentially useful for general population surveys, and particularly in migratory populations or those with infrequent contact with health services or opposed to blood withdrawal. Further studies will be needed to optimize collection methods, standardize volumes and content and develop controls

    Why Library and Information Science? Results of a Career Survey of MLIS Students Along with Implications for Reference Librarians and Recruitment

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    Hearing why the librarians of tomorrow chose the library profession is vital, because understanding their motivations provides librarians with a glimpse of the future as well as ways to improve that future for the profession. This article therefore seeks to communicate the career motivations of MLIS students by reporting the results of a survey conducted at the University of Alabama’s School of Library and Information Studies. Library administrators and others responsible for hiring information professionals will want to hear the library students’ reasons for entering the field, their salary expectations, geographic preferences, perceptions of the job market, and interest in various subfields. However, all librarians should seek to learn more about students’ career motivations and professional interests so that they can recruit more people to the profession and accommodate the needs of new colleagues. By using the survey results as a springboard, we propose several recruitment strategies with an emphasis on the key role of reference librarians in future campaigns. We also recommend that RUSA sponsor annual surveys similar to our own questionnaire so that the profession can adopt an informed approach to the recruitment dilemma

    Identification of larval sea basses (Centropristis spp.) using ribosomal DNA-specific molecular assays

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    This paper is not subject to U.S. copyright. The definitive version was published in Fishery Bulletin 106 (2008): 183-193.The identification of sea bass (Centropristis) larvae to species is difficult because of similar morphological characters, spawning times, and overlapping species ranges. Black sea bass (Centropristis striata) is an important fishery species and is currently considered to be overfished south of Cape Hatteras, North Carolina. We describe methods for identifying three species of sea bass larvae using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) assays based on species-specific amplification of rDNA internal transcribed spacer reg ions. The assays were tested against DNA of ten other cooccurring reef fish species to ensure the assay’s specificity. Centropristis larvae were collected on three cruises during cross-shelf transects and were used to validate the assays. Seventysix Centropristis larvae were assayed and 69 (91%) were identified successfully. DNA was not amplified from 5% of the larvae and identification was inconclusive for 3% of the larvae. These assays can be used to identify sea bass eggs and larvae and will help to assess spawning locations, spawning times, and larval dispersal.Collection of larvae at sea was supported by funding from the National Science Foundation through OCE 9876565 to C. Jones, S. Thorrold, A. Valle-Levinson, and J. Hare. Additional funding for this project was provided by Office of National Marine Sanctuaries and by Grays Reef National Marine Sanctuary

    QLS front-line retention manual: methods for achieving a 94% cohort retention rate in longitudinal research

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    Permission to include the report granted by Gary O’Connor, Chief Executive Officer, ONTARIO PROBLEM GAMBLING RESEARCH CENTREThis Front-Line Manual, written mainly by and from the perspective of the QLS front-line staff describes how they developed, tested, and put into practice the methodology to achieve their extremely high retention rate. By discussing the underlying rationale for different approaches and tools, as well as providing numerous specific practical examples, this manual will hopefully assist other longitudinal studies in improving retention rates, and thus the strength of the results of those studies.Ye

    Quinte longitudinal study of gambling and problem gambling

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    The Quinte Longitudinal Study (QLS) is a prospective study of gambling and problem gambling conducted in the Quinte region of Ontario, Canada from 2006 to 2011. A sample of 4,121 adults, 17 and older, was recruited via random digit telephone dialing with 26% of the sample overselected for higher levels of gambling involvement. The sample was roughly representative of the demographic profile of the Canadian adult population, and the geographic region had very similar gambling opportunities to the rest of Canada. The cohort was assessed annually over 5 years. Assessments were computerized and self-administered and were completed either online at the person’s home or at the QLS office in Belleville. The assessment collected comprehensive information on demographics, gambling behaviour, physical health, mental health, substance use and abuse, stressors, personal values, social functioning, personality, leisure activity, and intelligence. An exceptionally high retention rate of 93.9% after 5 years was achieved
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