Entwicklung eines pull-Konzepts mittels eines Simulationsmodells zur Betreuung der Anlaufphase der Serienfertigung von Brennstoffzellen

As technology advances, alternatives to the internal combustion engine, such as battery and fuel cell-driven electric mobility, are becoming increasingly attractive. Sustainable propulsion by battery has already been widely researched and is being mass-produced. The fuel cell, on the other hand, is not yet being produced to the same extent. To develop the fuel cell into a serious competitor to the battery, its series production must be targeted to further reduce costs. In addition, the increasing demand for fuel cells can only be satisfied through series production. For the flexible use of fuel cells in buses, trucks, and cars, production with a wide range of variants is also necessary. For the conception of series production, a realistic simulation of the material flow is an important component. This paper presents an approach for an intelligent pull concept to decouple material flow and at the same time reduce setup cost

mPGES-1 as a New Target for Garcinoic Acid Isoforms

International audienc

The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional african medicine

International audienc

Towards an Alternative to NSAIDs Based on Vitamin E Analogues

International audienc

Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors

International audienc

Garcinia species are potent and selective, allosteric inhibitors of 5-lipoxygenase and provide novel insights into human vitamin E physiology

International audienc

Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenase

International audienc

Leaf microbiome dysbiosis triggered by T2SS-dependent enzyme secretion from opportunistic Xanthomonas pathogens

In healthy plants, the innate immune system contributes to maintenance of microbiota homoeostasis, while disease can be associated with microbiome perturbation or dysbiosis, and enrichment of opportunistic plant pathogens like Xanthomonas. It is currently unclear whether the microbiota change occurs independently of the opportunistic pathogens or is caused by the latter. Here we tested if protein export through the type-2 secretion system (T2SS) by Xanthomonas causes microbiome dysbiosis in Arabidopsis thaliana in immunocompromised plants. We found that Xanthomonas strains secrete a cocktail of plant cell wall-degrading enzymes that promote Xanthomonas growth during infection. Disease severity and leaf tissue degradation were increased in A. thaliana mutants lacking the NADPH oxidase RBOHD. Experiments with gnotobiotic plants, synthetic bacterial communities and wild-type or T2SS-mutant Xanthomonas revealed that virulence and leaf microbiome composition are controlled by the T2SS. Overall, a compromised immune system in plants can enrich opportunistic pathogens, which damage leaf tissues and ultimately cause microbiome dysbiosis by facilitating growth of specific commensal bacteria.ISSN:2058-527

Computational analysis of the interaction between vitamin E derivatives and 5-lipoxygenase

International audienc