An earth pole-sitter using hybrid propulsion

In this paper we investigate optimal pole-sitter orbits using hybrid solar sail and solar electric propulsion (SEP). A pole-sitter is a spacecraft that is constantly above one of the Earth's poles, by means of a continuous thrust. Optimal orbits, that minimize propellant mass consumption, are found both through a shape-based approach, and solving an optimal control problem, using a direct method based on pseudo-spectral techniques. Both the pure SEP case and the hybrid case are investigated and compared. It is found that the hybrid spacecraft allows consistent savings on propellant mass fraction. Finally, is it shown that for sufficiently long missions (more than 8 years), a hybrid spacecraft, based on mid-term technology, enables a consistent reduction in the launch mass for a given payload, with respect to a pure SEP spacecraft

Generation of optimal trajectories for Earth hybrid pole sitters

A pole-sitter orbit is a closed path that is constantly above one of the Earth's poles, by means of continuous low thrust. This work proposes to hybridize solar sail propulsion and solar electric propulsion (SEP) on the same spacecraft, to enable such a pole-sitter orbit. Locally-optimal control laws are found with a semi-analytical inverse method, starting from a trajectory that satisfies the pole-sitter condition in the Sun-Earth circular restricted three-body problem. These solutions are subsequently used as first guess to find optimal orbits, using a direct method based on pseudospectral transcription. The orbital dynamics of both the pure SEP case and the hybrid case are investigated and compared. It is found that the hybrid spacecraft allows savings on propellant mass fraction. Finally, it is shown that for sufficiently long missions, a hybrid pole-sitter, based on mid-term technology, enables a consistent reduction in the launch mass for a given payload, with respect to a pure SEP spacecraft

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins is emerging as a promising therapeutic strategy. Despite intense efforts to rationally design degrader molecules that co-opt CRL4s, much about the organization and regulation of these ligases remains elusive. Here, we establish protein interaction kinetics and estimation of stoichiometries (PIKES) analysis, a systematic proteomic profiling platform that integrates cellular engineering, affinity purification, chemical stabilization, and quantitative mass spectrometry to investigate the dynamics of interchangeable multiprotein complexes. Using PIKES, we show that ligase assemblies of Cullin4 with individual substrate receptors differ in abundance by up to 200-fold and that Cand1/2 act as substrate receptor exchange factors. Furthermore, degrader molecules can induce the assembly of their cognate CRL4, and higher expression of the associated substrate receptor enhances degrader potency. Beyond the CRL4 network, we show how PIKES can reveal systems level biochemistry for cellular protein networks important to drug development

Interaction of quasilocal harmonic modes and boson peak in glasses

The direct proportionality relation between the boson peak maximum in glasses, $\omega_b$, and the Ioffe-Regel crossover frequency for phonons, $\omega_d$, is established. For several investigated materials $\omega_b = (1.5\pm 0.1)\omega_d$. At the frequency $\omega_d$ the mean free path of the phonons $l$ becomes equal to their wavelength because of strong resonant scattering on quasilocal harmonic oscillators. Above this frequency phonons cease to exist. We prove that the established correlation between $\omega_b$ and $\omega_d$ holds in the general case and is a direct consequence of bilinear coupling of quasilocal oscillators with the strain field.Comment: RevTex, 4 pages, 1 figur

Estimation of Spin-Spin Interaction by Weak Measurement Scheme

Precisely knowing an interaction Hamiltonian is crucial to realize quantum information tasks, especially to experimentally demonstrate a quantum computer and a quantum memory. We propose a scheme to experimentally evaluate the spin-spin interaction for a two-qubit system by the weak measurement technique initiated by Yakir Aharonov and his colleagues. Furthermore, we numerically confirm our proposed scheme in a specific system of a nitrogen vacancy center in diamond. This means that the weak measurement can also be taken as a concrete example of the quantum process tomography.Comment: 4 pages, 1 table, 2 figures, to appear in Europhysics Letter

Effect of Ghrelin Injection on Blood and Body Composition in Rats

Ghrelin has been reported to cause hyperglycemia in humans and adiposity in rodents. The objective of trial one was to test the effects of ghrelin on blood and body composition in rats. The objective of trial two was to evaluate the effect of two doses of ghrelin on blood and body composition. Trial One: Adult male Sprague Dawley rats were administered 1 μg/rat ghrelin in 0.15 M NaCl or vehicle (0.15 M NaCl) every morning for 30 days. The terminal blood sample was analyzed for glucose, urea nitrogen, and nonesterified fatty acids concentrations. The carcasses were analyzed for total lipid and nitrogen content. Blood urea nitrogen, nonesterified fatty acids, carcass total lipid, and carcass total nitrogen concentrations were similar for the control and ghrelin groups. However, blood glucose concentration tended to be higher in the ghrelin group than in the control. Ghrelin administered at 2.4 μg/kg did not cause adiposity in rats but did tend to cause hyperglycemia. Trial Two: Adult male Sprague Dawley rats were administered 1 μg/rat ghrelin, 20 μg/rat ghrelin, or vehicle every morning for 30 days. The terminal blood sample was analyzed for glucose and cholesterol concentrations. The carcasses were analyzed for total lipid and nitrogen content. Carcass total nitrogen concentrations were similar for the control and ghrelin groups. Carcass percent lipid was higher in the 1 μg/rat ghrelin group (P = 0.04). Feed intake among all three groups was the same. Blood glucose concentration, however, tended to be higher in the ghrelin groups than in the control. Blood cholesterol concentration was lower in the ghrelin treated animals. In the second trial, ghrelin injection of 1 μg/rat did cause an increase in adiposity whereas 20 μg/rat did not cause an increase in adiposity. Both ghrelin treatments tended to cause hyperglycemia in rats. In summary, ghrelin increased blood glucose concentration without changing body composition

Radiation Induced Degradation of the White Thermal Control Paints Z-93 and Z-93P

This paper details a comparison analysis of the zinc oxide pigmented white thermal control paints Z-93 and Z-93P. Both paints were simultaneously exposed to combined space environmental effects and analyzed using an in-vacuo reflectance technique. The dose applied to the paints was approximately equivalent to 5 years in a geosynchronous orbit. This comparison analysis showed that Z-93P is an acceptable substitute for Z-93. Irradiated samples of Z-93 and Z-93P were subjected to additional exposures of ultraviolet (UV) radiation and analyzed using the in-vacuo reflectance technique to investigate UV activated reflectance recovery. Both samples showed minimal UV activated reflectance recovery after an additional 190 equivalent sun hour (ESH) exposure. Reflectance response utilizing nitrogen as a repressurizing gas instead of air was also investigated. This investigation found the rates of reflectance recovery when repressurized with nitrogen are slower than when repressurized with air