1,418 research outputs found
Gottron's Papules Exhibit Dermal Accumulation of CD44 Variant 7 (CD44v7) and Its Binding Partner Osteopontin: A Unique Molecular Signature
The accumulated mucin in non-Gottron's dermatomyositis (DM) lesions is primarily chondroitin-4-sulfate (C4S), which is immunomodulatory in vitro. Gottron's papules are a particularly resistant manifestation of DM that often persist after other lesions have resolved with therapy. We examined non-Gottron's DM lesions and Gottron's papule skin biopsies for C4S, CD44 variant 7 (CD44v7), a chondroitin sulfate-binding isoform causally implicated in autoimmunity, and osteopontin (OPN), a CD44v7 ligand implicated in chronic inflammation. Gottron's papule dermis contained more C4S and CD44v7 than non-Gottron's lesions. Normal skin showed less CD44v7 over joints relative to Gottron's lesions. All DM dermis had increased OPN compared with healthy skin. Mechanically stretching cultured fibroblasts for 6hours induced CD44v7 mRNA and protein, whereas IFN-γ treatment induced OPN mRNA and protein. OPN alone did not induce CD44v7, but stretching dermal fibroblasts in the presence of OPN increased human acute monocytic leukemia cell line (THP-1) monocyte binding, which is blunted by anti-CD44v7 blocking antibody. C4S, CD44v7, and OPN are three molecules uniquely present in Gottron's papules that contribute to inflammation individually and in association with one another. We propose that stretch-induced CD44v7 over joints, in concert with dysregulated OPN levels in the skin of DM patients, increases local inflammatory cell recruitment and contributes to the pathogenesis and resistance of Gottron's papules
Routing Games over Time with FIFO policy
We study atomic routing games where every agent travels both along its
decided edges and through time. The agents arriving on an edge are first lined
up in a \emph{first-in-first-out} queue and may wait: an edge is associated
with a capacity, which defines how many agents-per-time-step can pop from the
queue's head and enter the edge, to transit for a fixed delay. We show that the
best-response optimization problem is not approximable, and that deciding the
existence of a Nash equilibrium is complete for the second level of the
polynomial hierarchy. Then, we drop the rationality assumption, introduce a
behavioral concept based on GPS navigation, and study its worst-case efficiency
ratio to coordination.Comment: Submission to WINE-2017 Deadline was August 2nd AoE, 201
Self-energy correction to the bound-electron g factor in H-like ions
The one-loop self-energy correction to the 1s electron g factor is evaluated
to all orders in Z\alpha with an accuracy, which is essentially better than
that of previous calculations of this correction. As a result, the uncertainty
of the theoretical prediction for the bound-electron g factor in H-like carbon
is reduced by a factor of 3. This improves the total accuracy of the recent
electron-mass determination [Beier et al. Phys. Rev. Lett. 88, 011603 (2002)].
The new value of the electron mass is found to be m_e = 0.000 548 579 909 3(3)
u
Zeeman effect of the hyperfine structure levels in hydrogenlike ions
The fully relativistic theory of the Zeeman splitting of the hyperfine
structure levels in hydrogenlike ions is considered for the magnetic field
magnitude in the range from 1 to 10 T. The second-order corrections to the
Breit -- Rabi formula are calculated and discussed. The results can be used for
a precise determination of nuclear magnetic moments from factor
experiments.Comment: 13 page
Evaluation of the self-energy correction to the g-factor of S states in H-like ions
A detailed description of the numerical procedure is presented for the
evaluation of the one-loop self-energy correction to the -factor of an
electron in the and states in H-like ions to all orders in .Comment: Final version, December 30, 200
Penning traps as a versatile tool for precise experiments in fundamental physics
This review article describes the trapping of charged particles. The main
principles of electromagnetic confinement of various species from elementary
particles to heavy atoms are briefly described. The preparation and
manipulation with trapped single particles, as well as methods of frequency
measurements, providing unprecedented precision, are discussed. Unique
applications of Penning traps in fundamental physics are presented.
Ultra-precise trap-measurements of masses and magnetic moments of elementary
particles (electrons, positrons, protons and antiprotons) confirm
CPT-conservation, and allow accurate determination of the fine-structure
constant alpha and other fundamental constants. This together with the
information on the unitarity of the quark-mixing matrix, derived from the
trap-measurements of atomic masses, serves for assessment of the Standard Model
of the physics world. Direct mass measurements of nuclides targeted to some
advanced problems of astrophysics and nuclear physics are also presented
Fabrication of a planar micro Penning trap and numerical investigations of versatile ion positioning protocols
We describe a versatile planar Penning trap structure, which allows to
dynamically modify the trapping conguration almost arbitrarily. The trap
consists of 37 hexagonal electrodes, each with a circumcirle-diameter of 300 m,
fabricated in a gold-on-sapphire lithographic technique. Every hexagon can be
addressed individually, thus shaping the electric potential. The fabrication of
such a device with clean room methods is demonstrated. We illustrate the
variability of the device by a detailed numerical simulation of a lateral and a
vertical transport and we simulate trapping in racetrack and articial crystal
congurations. The trap may be used for ions or electrons, as a versatile
container for quantum optics and quantum information experiments.Comment: 10 pages, 7 figures, pdflatex, to be published in New Journal of
Physics (NJP) various changes according to the wishes of the NJP referees.
Text added and moved around, title changed, abstract changed, references
added rev3: one reference had a typo (ref 15), fixed (phys rev a 72, not 71
g factor of Li-like ions with nonzero nuclear spin
The fully relativistic theory of the g factor of Li-like ions with nonzero
nuclear spin is considered for the (1s)^2 2s state. The magnetic-dipole
hyperfine-interaction correction to the atomic g factor is calculated including
the one-electron contributions as well as the interelectronic-interaction
effects of order 1/Z. This correction is combined with the
interelectronic-interaction, QED, nuclear recoil, and nuclear size corrections
to obtain high-precision theoretical values for the g factor of Li-like ions
with nonzero nuclear spin. The results can be used for a precise determination
of nuclear magnetic moments from g factor experiments.Comment: 20 pages, 5 figure
Recoil correction to the bound-electron g factor in H-like atoms to all orders in
The nuclear recoil correction to the bound-electron g factor in H-like atoms
is calculated to first order in and to all orders in . The
calculation is performed in the range Z=1-100. A large contribution of terms of
order and higher is found. Even for hydrogen, the higher-order
correction exceeds the term, while for uranium it is above the
leading correction.Comment: 6 pages, 3 tables, 1 figur
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