The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel

AbstractTRPM8, a member of the transient receptor potential family of ion channels, depolarizes somatosensory neurons in response to cold. TRPM8 is also activated by the cooling agents menthol and icilin. When exposed to menthol or cold, TRPM8 behaves like many ligand-gated channels, exhibiting rapid activation followed by moderate Ca2+-dependent adaptation. In contrast, icilin activates TRPM8 with extremely variable latency followed by extensive desensitization, provided that calcium is present. Here, we show that, to achieve full efficacy, icilin requires simultaneous elevation of cytosolic Ca2+, either via permeation through TRPM8 channels or by release from intracellular stores. Thus, two stimuli must be paired to elicit full channel activation, illustrating the potential for coincidence detection by TRP channels. Determinants of icilin sensitivity map to a region of TRPM8 that corresponds to the capsaicin binding site on the noxious heat receptor TRPV1, suggesting a conserved molecular logic for gating of these thermosensitive channels by chemical agonists

Removing Barriers, Integrating Research, Spreading Excellence: The European Satellite Communications Network of Excellence "SatNEx"

Within the recently launched 6th Research Framework Programme of the European Commission, 21 major players in satellite communications research have joined forces to implement the European Satellite Communications Network of Excellence (SatNEx). The primary goal of SatNEx is to achieve long-lasting integration of the European research in satellite communication and to develop a common base of knowledge, thus contributing to the realization of the European Research Area. This paper discusses the background and motivation for implementation of the network and highlights the SatNEx mission and key objectives. A top-level overview is then provided including a description of the consortium, the Joint Programme of Activities (JPA) and the time schedule with deliverables and milestones. Finally, an update of ongoing work is presented

Relations between entanglement, Bell-inequality violation and teleportation fidelity for the two-qubit X states

Based on the assumption that the receiver Bob can apply any unitary transformation, Horodecki {\it et al.} [Phys. Lett. A {\bf 222}, 21 (1996)] proved that any mixed two spin-1/2 state which violates the Bell-CHSH inequality is useful for teleportation. Here, we further show that any X state which violates the Bell-CHSH inequality can also be used for nonclassical teleportation even if Bob can only perform the identity or the Pauli rotation operations. Moreover, we showed that the maximal difference between the two average fidelities achievable via Bob's arbitrary transformations and via the sole identity or the Pauli rotation is 1/9.Comment: 5 pages, to be published in "Quantum Information Processing

New LpL_p Affine Isoperimetric Inequalities

We prove new $L_p$ affine isoperimetric inequalities for all $p \in [-\infty,1)$. We establish, for all $p\neq -n$, a duality formula which shows that $L_p$ affine surface area of a convex body $K$ equals $L_\frac{n^2}{p}$ affine surface area of the polar body $K^\circ$

Bifurcation analysis of dynamic systems with continuously piecewise linearity

The periodic response and associated bifurcations of a harmonically driven oscillator with continuously piecewise linearity has received great attention during the past decade. The oscillator serves as a widely used model to describe various mechanical systems with clearances, elastic constraints etc. Even if the 'corners' of the piecewise-linear restoring force in the oscillator make the system non-smooth on the interface between two linear regions, the bifurcation analysis published up to now is still based on the theory of smooth dynamic systems. The validity of such an extention is an open problem

Exotic d-wave superconductivity in strongly hole doped K(x)Ba(1-x)Fe2As2

We investigate the superconducting phase in the K(x)Ba(1-x)Fe2As2 122 compounds from moderate to strong hole-doping regimes. Using functional renormalization group, we show that while the system develops a nodeless anisotropic s+- order parameter in the moderately doped regime, gapping out the electron pockets at strong hole doping drives the system into a nodal cos (kx) cos (ky) d-wave superconducting state. This is in agreement with recent experimental evidence from measurements on KFe2As2 which see a nodal order parameter in the extreme doping regime. The magnetic instability is strongly suppressed. The case of only hole pockets present is argued to be structurally similar to the case of only electron pockets present as indicated for KxFe2Se2.Comment: 4.2 pages, 4 figures; version as published in PR

Detection of C60 in the proto-planetary nebula IRAS 01005+7910

We report the first detection of buckminsterfullerene (C60) in a proto-planetary nebula (PPN). The vibrational transitions of C60 at 7.0, 17.4, and 18.9um are detected in the Spitzer/IRS spectrum of IRAS 01005+7910. This detection suggests that fullerenes are formed shortly after the asymptotic giant branch but before the planetary nebulae stage. A comparison with the observations of C60 in other sources is made and the implication on circumstellar chemistry is discussed.Comment: 14 pages, 4 figures, accepted for publication in Ap

A Knotted Meta-molecule with 2-D Isotropic Optical Activity Rotating the Incident Polarization by 90{\deg}

Optical activity is the ability of chiral materials to rotate linearly-polarized (LP) electromagnetic waves. Because of their intrinsic asymmetry, traditional chiral molecules usually lack isotropic performance, or at best only possess a weak form of chirality. Here we introduce a knotted chiral meta-molecule that exhibits optical activity corresponding to a 90{\deg} polarization rotation of the incident waves. More importantly, arising from the continuous multi-fold rotational symmetry of the chiral torus knot structure, the observed polarization rotation behavior is found to be independent of how the incident wave is polarized. In other words, the proposed chiral knot structure possesses two-dimensional (2-D) isotropic optical activity as illustrated in Fig. 1, which has been experimentally validated in the microwave spectrum. The proposed chiral torus knot represents the most optically active meta-molecule reported to date that is intrinsically isotropic to the incident polarization