42 research outputs found
ΠΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π² ΠΌΠ½ΠΎΠ³ΠΎΡΠ°Π·Π½ΠΎΠΌ ΠΌΠΎΡΡΠΎΠ²ΠΎΠΌ ΠΈΠ½Π²Π΅ΡΡΠΎΡΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ
Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π² ΠΌΠ½ΠΎΠ³ΠΎΡΠ°Π·Π½ΠΎΠΌ, ΠΌΠΎΡΡΠΎΠ²ΠΎΠΌ ΠΈΠ½Π²Π΅ΡΡΠΎΡΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠΌΠΌΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
; ΡΡΠ½ΠΊΡΠΈΠΉ ΠΈ ΡΠ΅ΠΎΡΠΈΠΈ Π»ΠΈΠ½Π΅ΠΉΠ½ΡΡ
ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΡΡ
ΡΡ
Π΅ΠΌ. ΠΠ»Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎ-ΠΈΠ½Π΄ΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ΠΎ ΡΠ΅Π³ΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ ΡΠΈΡΠΎΡΠ½ΠΎ-ΠΈΠΌΠΏΡΠ»ΡΡΠ½ΠΎΠΉ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠ΅ΠΉ ΠΏΠΎ ΡΠΈΠ½ΡΡΠΎΠΈΠ΄Π°Π»ΡΠ½ΠΎΠΌΡ ΠΈ ΠΏΡΡΠΌΠΎΡΠ³ΠΎΠ»ΡΠ½ΠΎΠΌΡ Π·Π°ΠΊΠΎΠ½Π°ΠΌ. ΠΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ Π½Π΅ΡΡΡΠ΅ΠΉ ΠΈ Π²ΡΡ
ΠΎΠ΄Π½ΠΎΠΉ ΡΠ°ΡΡΠΎΡ ΠΈΠ· ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΎΠ±ΠΌΠ΅Π½Π° ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ½Π΅ΡΠ³ΠΈΠΈ Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΈ ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½ΡΠ° Π³Π°ΡΠΌΠΎΠ½ΠΈΠΊ ΠΏΠΎ ΡΠΎΠΊΡ ΠΏΡΠ΅Π΄ΠΏΠΎΡΡΠΈΡΠ΅Π»ΡΠ½Π° ΠΏΡΡΠΌΠΎΡΠ³ΠΎΠ»ΡΠ½Π°Ρ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΡ. ΠΠ΅Π»Π°Π΅ΡΡΡ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΡ
Π΅ΠΌ ΠΈΠ½Π²Π΅ΡΡΠΎΡΠΎΠ² Ρ Π½Π΅ΡΠ΅ΡΠ½ΡΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎΠΌ ΡΠ°Π· ΠΈ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΈ Π½Π°Π³ΡΡΠ·ΠΊΠΈ Π² Π·Π²Π΅Π·Π΄Ρ. ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ ΠΊΠ²Π°Π·ΠΈΡΡΡΠ°Π½ΠΎΠ²ΠΈΠ²ΡΠΈΡ
ΡΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² Π². ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΈΠ½Π²Π΅ΡΡΠΎΡ-Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»Ρ ΠΌΠ½ΠΎΠ³ΠΎΡΠ°Π·Π½ΡΠΉ Π°ΡΠΈΠ½Ρ
ΡΠΎΠ½Π½ΡΠΉ ΠΊΠΎΡΠΎΡΠΊΠΎΠ·Π°ΠΌΠΊΠ½ΡΡΡΠΉ Π΄Π²ΠΈΠ³Π°ΡΠ΅Π»Ρ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ ΠΊ ΡΠΊΠ²ΠΈΠ²Π°Π»Π΅Π½ΡΠ½ΠΎΠΉ Π΄Π²ΡΡ
ΡΠ°Π·Π½ΠΎΠΉ ΠΌΠ°ΡΠΈΠ½Π΅ ΠΈ Π²ΡΠ΅ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡΠ΅ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½Π½ΡΡ
Π²Π΅ΠΊΡΠΎΡΠΎΠ². ΠΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ Π½Π΅ΡΡΡΠ΅ΠΉ ΠΈ Π²ΡΡ
ΠΎΠ΄Π½ΠΎΠΉ ΡΠ°ΡΡΠΎΡ ΡΠ°ΠΊΠΆΠ΅ Π²ΡΠ²ΠΎΠ΄ΡΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΏΡΡΠΌΠΎΡΠ³ΠΎΠ»ΡΠ½ΠΎΠΉ ΠΌΠΎΠ΄ΡΠ»ΡΡΠΈΠΈ ΠΏΠΎ Π²Π΅Π»ΠΈΡΠΈΠ½Π΅ ΠΏΡΠ»ΡΡΠ°ΡΠΈΠΈ, ΠΌΠΎΠΌΠ΅Π½ΡΠ° ΠΈ ΡΠΊΠΎΡΠΎΡΡΠΈ
Isolated Eigenvalues of the Ferromagnetic Spin-J XXZ Chain with Kink Boundary Conditions
We investigate the low-lying excited states of the spin J ferromagnetic XXZ
chain with Ising anisotropy Delta and kink boundary conditions. Since the third
component of the total magnetization, M, is conserved, it is meaningful to
study the spectrum for each fixed value of M. We prove that for J>= 3/2 the
lowest excited eigenvalues are separated by a gap from the rest of the
spectrum, uniformly in the length of the chain. In the thermodynamic limit,
this means that there are a positive number of excitations above the ground
state and below the essential spectrum
Implementing Quantum Gates using the Ferromagnetic Spin-J XXZ Chain with Kink Boundary Conditions
We demonstrate an implementation scheme for constructing quantum gates using
unitary evolutions of the one-dimensional spin-J ferromagnetic XXZ chain. We
present numerical results based on simulations of the chain using the
time-dependent DMRG method and techniques from optimal control theory. Using
only a few control parameters, we find that it is possible to implement one-
and two-qubit gates on a system of spin-3/2 XXZ chains, such as Not, Hadamard,
Pi-8, Phase, and C-Not, with fidelity levels exceeding 99%.Comment: Updated Acknowledgement
Transport of interface states in the Heisenberg chain
We demonstrate the transport of interface states in the one-dimensional
ferromagnetic Heisenberg model by a time dependent magnetic field. Our analysis
is based on the standard Adiabatic Theorem. This is supplemented by a numerical
analysis via the recently developed time dependent DMRG method, where we
calculate the adiabatic constant as a function of the strength of the magnetic
field and the anisotropy of the interaction.Comment: minor revision, final version; 13 pages, 4 figure
SWITCH : A randomised, sequential, open-label study to evaluate the efficacy and safety of Sorafenib-sunitinib versus Sunitinib-sorafenib in the treatment of metastatic renal cell cancer
Background
Understanding how to sequence targeted therapies for metastatic renal
cell carcinoma (mRCC) is important for maximisation of clinical benefit.
Objectives
To prospectively evaluate sequential use of the multikinase inhibitors sorafenib followed by sunitinib (So-Su) versus sunitinib followed by sorafenib (Su-So) in patients with mRCC.
Design, setting, and participants
The multicentre, randomised, open-label, phase 3 SWITCH study assessed So-Su versus Su-So in patients with mRCC without prior systemic therapy, and stratified by Memorial Sloan Kettering Cancer Center risk score (favourable or intermediate).
Intervention
Patients were randomised to sorafenib 400 mg twice daily followed, on progression or intolerable toxicity, by sunitinib 50 mg once daily (4 wk on, 2 wk off) (So-Su), or vice versa (Su-So).
Outcome measurements and statistical analysis
The primary endpoint was improvement in progression-free survival (PFS) with So-Su versus Su-So, assessed from randomisation to progression or death during second-line therapy. Secondary endpoints included overall survival (OS) and safety.
Results and limitations
In total, 365 patients were randomised (So-Su, n = 182; Su-So, n = 183). There was no significant difference in total PFS between So-Su and Su-So (median 12.5 vs 14.9 mo; hazard ratio [HR] 1.01; 90% confidence interval [CI] 0.81β1.27; p = 0.5 for superiority). OS was similar for So-Su and Su-So (median 31.5 and 30.2 mo; HR 1.00, 90% CI 0.77β1.30; p = 0.5 for superiority). More So-Su patients than Su-So patients reached protocol-defined second-line therapy (57% vs 42%). Overall, adverse event rates were generally similar between the treatment arms. The most frequent any-grade treatment-emergent first-line adverse events were diarrhoea (54%) and hand-foot skin reaction (39%) for sorafenib; and diarrhoea (40%) and fatigue (40%) for sunitinib.
Conclusions
Total PFS was not superior with So-Su versus Su-So. These results demonstrate that sorafenib followed by sunitinib and vice versa provide similar clinical benefit in mRCC