11 research outputs found
Diario de Valencia: Diario de Valencia - Año XV Número 4933 - 1925 noviembre 3 (03/11/1925)
Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory
AbstractMammalian target of rapamycin (mTOR), a central regulator of protein synthesis in neurons, has been implicated in synaptic plasticity and memory. Here we show that mTOR inhibition by rapamycin in the basolateral amygdala (BLA) or dorsal hippocampus (DH) impairs both formation and reconsolidation of memory for inhibitory avoidance (IA) in rats. Male Wistar rats received bilateral infusions of vehicle or rapamycin into the BLA or DH before or after IA training or retrieval. Memory retention was tested at different time points after drug infusion. Rapamycin impaired long-term IA retention when given before or immediately after training or retrieval into the BLA. When infused into the DH, rapamycin produced memory impairment when given before training or immediately after retrieval. The impairing effects of post-retrieval rapamycin required memory retrieval and were not reversed by a reminder shock. The results provide the first evidence that mTOR in the BLA and DH might play a role in IA memory reconsolidation
EFEITO DA ADMINISTRAÇÃO INTRAHIPOCAMPAL DE MANGIFERINA SOBRE A CONSOLIDAÇÃO DA MEMÓRIA AVERSIVA EM RATOS
EFEITO DA INIBIÇÃO DE HISTONAS DESACETILASES NO HIPOCAMPO DORSAL NA MEMÓRIA AVERSIVA EM RATOS.
Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment
Efeito da administração de Rolipram no hipocampo e amígdala de ratos durante a consolidação da memória na tarefa de reconhecimento de objeto
Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats
Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment