Talent Flow Network, the Life Cycle of Firms, and Their Innovations

This paper explores how talent flow network and the firm life cycle affect the innovative performances of firms. We first established an interorganizational talent flow network with the occupational mobility data available from the public resumes on LinkedIn China. Thereafter, this information was combined with the financial data of China’s listed companies to develop a unique dataset for the time period between 2000 and 2015. The empirical results indicate the following: (1) The breadth and depth of firms’ embedding in the talent flow network positively impact their innovative performances; (2) Younger firms’ innovations are mostly promoted by the breadth of network embedding, but this positive effect weakens as firms increase in age; (3) Mature firms’ innovations are primarily driven by the depth of network embedding, and this positive effect strengthens as firms increase in age. This paper enriches and deepens the studies of talent flow networks, and it provides practical implications for innovation management based on talent flow for various types of firms at different development stages

Exploring the shared genes of hypertension, diabetes and hyperlipidemia based on microarray

Given their relationship with metabolic syndrome and systematic inflammatory diseases, the pathogenesis of hypertension, hyperglycemia, and hyperlipidemia is closely related. To explore the common genes among these three conditions, spontaneous hypertensive rats (SHR), spontaneous diabetic Goto-Kakizaki rats (GK) and hyperlipidemia rats (HMR) were reared for experiments. Gene array was used to identify the genes of SHR, GK and HMR compared with normal Wistar rats using TBtools software. First, real-time PCR was applied to verify these genes, and Cytoscape software was used to construct networks based on the National Center for Biotechnology Information (NCBI) database. Second, Kyoto Encyclopedia of Genes and Genomes (KEGG) database analysis was performed to classify the genes. Visualization and Integrated Discovery (DAVID) database and Gene Ontology database were used to explore the biological function. Finally, Onto-tools Pathway Express was used to analyze the pathways of shared genes. Importantly, upregulated common genes, such as Bad, Orm1, Arntl and Zbtb7a, were used to construct a network of 150 genes, while downregulated genes, such as Mif and Gpx1, formed a network of 29 genes. Interestingly, the networks were involved in various pathways, such as insulin signal pathway, endometrial cancer pathway, circadian rhythm pathway, and pancreatic cancer pathway. We discovered common genes of SHR, GK and HMR compared with normal Wistar rats, and the association of these genes together with biological function were preliminarily revealed

Tree-ring stable carbon isotope-based April-June relative humidity reconstruction since AD 1648 in Mt. Tianmu, China

Based on accurate dating, we have determined the stable carbon isotope ratios (delta C-13) of five Cryptomeria fortunei specimens from Mt. Tianmu, a subtropical area in southern China. The five delta C-13 time series records are combined into a single representative delta C-13 time series using a "numerical mix method." These are normalized to remove temporal variations of delta(13) C in atmospheric CO2 to obtain a carbon isotopic discrimination (Delta C-13) time series, in which we observe a distinct correlation between Delta C-13 and local April to June mean relative humidity (RH (AMJ) ) (n = 64, r = 0.858, p < 0.0001). We use this relationship to reconstruct RH (AMJ) variations from ad 1648 to 2014 at Mt. Tianmu. The reconstructed sequence show that over the past 367 years, Mt. Tianmu area was relatively wet, but in the latter part of the twentieth century, under the influence of increasing global warming, it has experienced a sharp reduction in relative humidity. Spatial correlation analysis reveals a significant negative correlation between RH (AMJ) at Mt. Tianmu and Sea Surface Temperature (SSTs) in the western equatorial Pacific and Indian Ocean. In other words, there is a positive correlation between tree-ring delta C-13 in Mt. Tianmu and SSTs. Both observed and reconstructed RH (AMJ) show significant positive correlations with East Asian and South Asian monsoons from 1951 to 2014, which indicate that RH (AMJ) from Mt. Tianmu reflects the variability of the Asian summer monsoon intensity to a great extent. The summer monsoon has weakened since 1960. However, an increase in relative humidity since 2003 implies a recent enhancement in the summer monsoon

Shengmai San Alleviates Diabetic Cardiomyopathy Through Improvement of Mitochondrial Lipid Metabolic Disorder

Background/Aims: Shengmai San (SMS), prepared from Panax ginseng, Ophiopogon japonicus, and Schisandra chinensisin, has been widely used to treat ischemic disease. In this study, we investigated whether SMS may exert a beneficial effect in diabetic cardiomyopathy through improvement of mitochondrial lipid metabolism. Methods: A leptin receptor-deficient db/db mouse model was utilized, and lean age-matched C57BLKS mice served as non-diabetic controls. Glucose and lipid profiles, myocardial structure, dimension, and function, and heart weight to tibial length ratio were determined. Myocardial ultrastructural morphology was observed with transmission electron microscopy. Protein expression and activity of oxidative phosphorylation (OXPHOS) complex were assessed using western blotting and microplate assay kits. We also observed cellular viability, mitochondrial membrane potential, OXPHOS complex activity, and cellular ATP level in palmitic acid-stimulated H9C2 cardiomyocytes. Changes in the sirtuin (SIRT1)/AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) pathway and mitochondrial uncoupling signaling were assessed using western blotting and quantitative real-time PCR. Results: Leptin receptor-deficient db/db mice exhibit obesity, hyperglycemia, and hyperlipidemia, accompanied by distinct myocardial hypertrophy and diastolic dysfunction. SMS at a dose of 3 g/kg body weight contributed to a recovery of diabetes-induced myocardial hypertrophy and diastolic dysfunction. SMS administration led to an effective restoration of mitochondrial structure and function both in vivo and in vitro. Furthermore, SMS markedly enhanced SIRT1 and p-AMPKα protein levels and decreased the expression of acetylated-PGC-1α and uncoupling protein 2 protein. SMS also restored the depletion of NRF1 and TFAM levels in diabetic hearts and H9C2 cardiomyocytes. Conclusion: The results indicate that SMS may alleviate diabetes-induced myocardial hypertrophy and diastolic dysfunction by improving mitochondrial lipid metabolism

Morphological diversity and altitudinal differentiation of Aethopyga species

Abstract The morphological characteristics of birds are an important tool for studying their adaptation and evolution. The morphological evolution of a clade is not only constrained by the phylogenetic relationship, but also influenced by ecological factors and interspecific competition. Aethopyga is a group of small nectar‐eating birds with obvious sexual dimorphism. They have slender and decurved beaks, which reflect their unique diet and foraging mode. Traditional and geometric morphometrics were combined to characterize the body morphology and beak shape of six species of Aethopyga distributed in China. We aim to assess the roles of phylogeny, altitude, and species interactions to morphological evolution. The main distinguishing characteristic among these six species were overall body size, the ratio of body weight, culmen and tarsal length to body length, tail length and wing length, and beak shape (slender/straight vs. thick/decurved). Although these dimensions cannot distinguish all species, they can show a clear distribution trend, and there is a significant Mahalanobis distance between each pair of species. There were no significant phylogenetic signals in morphological traits. The results of PGLS analysis show that altitude is significantly correlated with log‐transformed tarsus length and beak‐shaped PC1 (slender/straight vs thick/decurved dimensions) across the six species analyzed. Mantel test shows that the distance matrix of beak morphological characteristics showed a significant correlation with the altitudinal distance matrix. The results indicated no significant phylogenetic signal in the morphological characteristics of six species. In terms of beak shape, species with greater overlap in elevation distribution have more similar morphological characteristics, that is, less morphological differentiation

Segmental resection combined with anoplasty for the treatment of circumferential mixed hemorrhoids

Circumferential mixed hemorrhoids are very difficult to treat non-surgically. Therefore, it is important to explore the surgical methods for its complete resolution as well as maintenance of normal anal anatomy and function. The present study was designed to evaluate the effect of segmented and plastic hemorrhoidectomy (SPH) on patients with circumferential mixed hemorrhoids. A total of 300 patients with circumferential mixed hemorrhoids were divided into experimental group (n=150) undergoing SPH and control group (n=150) undergoing Milligan-Morgan hemorrhoidectomy. There were no differences in cure and effectiveness rates between two groups. Compared with the control group, patients in the experimental group had shorter healing time (15.7±1.3 vs 12.5±0.7 days) and recovery to normal activity (18.5±2.7 vs 14.7±1.2 days). In addition, anal function of all patients in the experimental group was normal during short- and long-term follow-up. However, more cases in the control group showed anal dampness and itching, and poor control of intestinal liquid. Compared with the control group, patients in the experimental group had better outcomes in overall anal function and smoothness at 6, 12, and 18 months after operation as well as patient satisfaction. Furthermore, the rating in the visual analogue scale for defecation pain and edema in the experimental group was less than that in the control group. SPH was more effective, had fewer complications, better protection of anal function, and a better cosmetic result

The Effect of Job Security on Deviant Behaviors in Diverse Employment Workplaces: From the Social Identity Perspective

Organizational scholars concur that job security can attach employees to a workplace and improve their job quality. The relationship between job security and employees’ deviant behaviors in the workplace, such as counterproductive work behavior (CWB), lacks insights into how or why this occurs, especially in a diversified employment context. To address these limitations, we developed a theoretical model of job security impact on employees’ CWB from the perspective of social identity. Analysis of employees (N = 208) and their supervisors in a China state-owned company were used to test the hypothesis. Results confirmed the negative relationship between job security and CWB; organizational identification partly mediates the relationship between job security and CWB. Moderated mediation analyses further indicate that the indirect effect of job security on CWB via organizational identification are stronger for temporary employees than for permanent employees. This article contributes to the understanding of job security’s impact on employees’ deviant behavior, practical implications and research aspects are discussed

Comparing machine learning methods for predicting land development intensity.

Land development intensity is a comprehensive indicator to measure the degree of saving and intensive land construction and economic production activities. It is also the result of the joint action of natural, social, economic, and ecological elements in land development and utilization. Scientific prediction of land development intensity has particular reference significance for future regional development planning and the formulation of reasonable land use policies. Based on the inter-provincial land development intensity and its influencing factors in China, this study applied four algorithms, XGBoost, random forest model, support vector machine, and decision tree, to simulate and predict the land development intensity, and then compared the prediction accuracy of the four algorithms, and also carried out hyperparameter adjustment and prediction accuracy verification. The results show that the model with the best prediction performance among the four algorithms is XGBoost, and its R2 and MSE between predicted and valid values are 95.66% and 0.16, respectively, which are higher than the other three models. During the training process, the learning curve of the XGBoost model exhibited low fluctuation and fast fitting. Hyperparameter tuning is crucial to exploit the model's potential. The XGBoost model has the best prediction performance with the best hyperparameter combination of max_depth:19, learning_rate: 0.47, and n_estimatiors:84. This study provides some reference significance for the simulation of land development and utilization dynamics

Isolation and Properties of <i>Enterobacter</i> sp. LX3 Capable of Producing Indoleacetic Acid

Indoleacetic acid (IAA) can act as a phytohormone to modulate plant growth and development, thus persistent search for IAA-producing microbes is underway for a potential application in promoting plant growth. In this paper, an IAA-producing bacterium was obtained from maize rhizosphere in biochar-amending field. This strain is a Gram-negative and facultative anaerobic rod. Phenotypic examination and 16S rRNA gene sequencing suggest that this strain is a new strain of the Enterobacter species. We designated this strain LX3. LX3 produced up to 200 mg/L of IAA in nutrient broth and promoted barley development and increased plant chlorophyll level. This suggests that LX3 has potential as a biofertilizer