8,001 research outputs found

    Modeling loop backbone flexibility in receptor-ligand docking simulations

    Get PDF

    Validation of purdue engineering shape benchmark clusters by crowdsourcing

    Get PDF
    The effective organization of CAD data archives is central to PLM and consequently content based retrieval of 2D drawings and 3D models is often seen as a "holy grail" for the industry. Given this context, it is not surprising that the vision of a "Google for shape", which enables engineers to search databases of 3D models for components similar in shape to a query part, has motivated numerous researchers to investigate algorithms for computing geometric similarity. Measuring the effectiveness of the many approaches proposed has in turn lead to the creation of benchmark datasets against which researchers can compare the performance of their search engines. However to be useful the datasets used to measure the effectiveness of 3D retrieval algorithms must not only define a collection of models, but also provide a canonical specification of their relative similarity. Because the objective of shape retrieval algorithms is (typically) to retrieve groups of objects that humans perceive as "similar" these benchmark similarity relationships have (by definition) to be manually determined through inspection

    Retention of mouth-to-mouth, mouth-to-mask and mouth-to-face shield ventilation

    Get PDF
    Background: Retention of mouth-to-mouth, mouth-to-mask and mouth-to-face shield ventilation techniques is poorly understood.Methods: A prospective randomised clinical trial was undertaken in January 2004 in 70 candidates randomly assigned to training in mouth-to-mouth, mouth-to-mask or mouth-to-face shield ventilation. Each candidate was trained for 10 min, after which tidal volume, respiratory rate, minute volume, peak airway pressure and the presence or absence of stomach inflation were measured. 58 subjects were reassessed 1 year later and study parameters were recorded again. Data were analysed with ANOVA, \textgreekq2 and McNemar tests.Results: Tidal volume, minute volume, peak airway pressure, ventilation rate and stomach inflation rate increased significantly at reassessment with all ventilation techniques compared with the initial assessment. However, at reassessment, mean (SD) tidal volume (960 (446) vs 1008 (366) vs 1402 (302) ml; p<0.05), minute volume (12 (5) vs 13 (7) vs 18 (3) l/min; p<0.05), peak airway pressure (14 (8) vs 17 (13) vs 25 (8) cm H2O; p<0.05) and stomach inflation rate (63% vs 58% vs 100%; p<0.05) were significantly lower with mouth-to-mask and mouth-to-face shield ventilation than with mouth-to-mouth ventilation. The ventilation rate at reassessment did not differ significantly between the ventilation techniques.Conclusions: One year after a single episode of ventilation training, lay persons tended to hyperventilate; however, the degree of hyperventilation and resulting stomach inflation were lower when a mouth-to-mask or a face shield device was employed. Regular training is therefore required to retain ventilation skills; retention of skills may be better with ventilation devices

    SLIM: An Improved Generalized Born Implicit Membrane Model

    Get PDF

    Geometric reasoning via internet crowdsourcing

    Get PDF
    The ability to interpret and reason about shapes is a peculiarly human capability that has proven difficult to reproduce algorithmically. So despite the fact that geometric modeling technology has made significant advances in the representation, display and modification of shapes, there have only been incremental advances in geometric reasoning. For example, although today's CAD systems can confidently identify isolated cylindrical holes, they struggle with more ambiguous tasks such as the identification of partial symmetries or similarities in arbitrary geometries. Even well defined problems such as 2D shape nesting or 3D packing generally resist elegant solution and rely instead on brute force explorations of a subset of the many possible solutions. Identifying economic ways to solving such problems would result in significant productivity gains across a wide range of industrial applications. The authors hypothesize that Internet Crowdsourcing might provide a pragmatic way of removing many geometric reasoning bottlenecks.This paper reports the results of experiments conducted with Amazon's mTurk site and designed to determine the feasibility of using Internet Crowdsourcing to carry out geometric reasoning tasks as well as establish some benchmark data for the quality, speed and costs of using this approach.After describing the general architecture and terminology of the mTurk Crowdsourcing system, the paper details the implementation and results of the following three investigations; 1) the identification of "Canonical" viewpoints for individual shapes, 2) the quantification of "similarity" relationships with-in collections of 3D models and 3) the efficient packing of 2D Strips into rectangular areas. The paper concludes with a discussion of the possibilities and limitations of the approach

    A new two-pole accretion polar: RX J1846.9+5538

    Get PDF
    We report the discovery of a new, bright (V = 17 mag) AM Her system as the optical counterpart of the soft ROSAT All-Sky-Survey source RX J1846.9+5538 (= 1RXS J184659.4+553834). Optical photometric and spectroscopic follow-up observations reveal a single period of 128.7 min, consistent with a high degree of spin-orbit synchronization, and a low polar field strength (B<20B<20 MG) of the primary accretion region. The system was observed in optical intermediate and high states that differ by about 1 mag. These brightness variations were accompanied by a correlated change of the optical light curve, which we interpret as a switch between one- and two-pole accretion. This explanation is also supported by the X-ray light curves, which at two different epochs display emission from two equally bright accretion regions separated by 160 degrees. Both spots possess distinct spectral X-ray properties as seen from the X-ray hardness ratio, where the secondary accretion region appears significantly softer, thus probably indicating a higher field strength compared to the primary region. In all ROSAT pointings a deep dip is present during the primary flux maxima, very likely caused by absorption in one of the accretion streams.Comment: 11 pages, 9 figures; accepted for publication in Astronomy & Astrophysic
    • 

    corecore