Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy

Galectin-1 (Gal-1) has been proved to be an important factor in the process of tumor angiogenesis recently. As a small molecule, OTX008 serves as a selective inhibitor of Gal-1. In this study, the role of Gal-1 and the antiangiogenic effect of OTX008 on retinal neovascularization (RNV) were investigated using a mouse model of oxygen-induced retinopathy. The outcome indicated that Gal-1 was overexpressed and closely related to retinal neovessels in OIR. After intravitreal injection of OTX008 at P12, the RNV was significantly reduced at P17, measuring by cross-sectional H&E staining and whole-mount fluorescence. Our results demonstrate the inhibitory function of OTX008 on RNV, which provides a promising strategy of treating retinal angiogenic diseases such as retinopathy of prematurity and proliferative diabetic retinopathy

Zero Index Metamaterial for High Gain Array

Many metamaterials, including metal wire grid, was invented to enhance the performance of the antenna in the last decade. A novel zero index metamaterial (ZIM), consisting of double metal layers with periodic circular perforation cells, was proposed and studied for horn antenna loading in this paper. The simulation model of array loaded with ZIM was constructed and optimized by CST software. The results indicate that array loaded with ZIM shows an enhanced performance at the resonant frequency and could be used for antenna loading application. An experimental study was also carried out to verify the design of ZIM. The measured resonant frequency of ZIM shows a good agreement with the results of the derived analytical formula. A maximum of 2.3 dB gain enhancement and 0.88 aperture efficiency at 9.3GHz was observed according to the measurement. Compared with typical standard horn with the same aperture, the tapering length of array loaded with ZIM was reduced by half, and the aperture efficiency demonstrates more than 70% increase at the resonant frequency in the meantime

A Survey of Hybrid Human-Artificial Intelligence for Social Computing

Along with the development of modern computing technology and social sciences, both theoretical research and practical applications of social computing have been continuously extended. In particular with the boom of artificial intelligence (AI), social computing is significantly influenced by AI. However, the conventional technologies of AI have drawbacks in dealing with more complicated and dynamic problems. Such deficiency can be rectified by hybrid human-artificial intelligence (H-AI) which integrates both human intelligence and AI into one unity, forming a new enhanced intelligence. H-AI in dealing with social problems shows the advantages that AI can not surpass. This paper firstly introduces the concept of H-AI. AI is the intelligence in the transition stage of H-AI, so the latest research progresses of AI in social computing are reviewed. Secondly, it summarizes typical challenges faced by AI in social computing, and makes it possible to introduce H-AI to solve these challenges. Finally, the paper proposes a holistic framework of social computing combining with H-AI, which consists of four layers: object layer, base layer, analysis layer, and application layer. It represents H-AI has significant advantages over AI in solving social problems

Co-Evolution of Emerging Multi-Cities: Rates, Patterns and Driving Policies Revealed by Continuous Change Detection and Classification of Landsat Data

The co-evolution of multi-cities has emerged as the primary form of urbanization in China in recent years. However, the processes, patterns, and coordination are not well characterized and understood, which hinders the understanding of the driving forces, consequences, and management of polycentric urban development. We used the Continuous Change Detection and Classification (CCDC) algorithm to integrate all available Landsat 5, 7, and 8 images and map annual land use and land cover (LULC) from 2001 to 2017 in the Chang–Zhu–Tan urban agglomeration (CZTUA), a typical urban agglomeration in China. Results showed that the impervious surface in the study area expanded by 371 km2 with an annual growth rate of 2.25%, primarily at the cost of cropland (169 km2) and forest (206 km2) during the study period. Urban growth has evolved from infilling being the dominant type in the earlier period to mainly edge-expansion and leapfrogging in the core cities, and from no dominant type to mainly leapfrogging in the satellite cities. The unfolding of the “cool center and hot edge” urban growth pattern in CZTUA, characterized by higher expansion rates in the peripheral than in the core cities, may signify a new form of the co-evolution of multi-cities in the process of urbanization. Detailed urban management and planning policies in CZTUA were analyzed. The co-evolution of multi-cities principles need to be studied in more extensive regions, which could help policymakers to promote sustainable and livable development in the future

Video1_Flare quasi-periodic pulsation associated with recurrent jets.MP4

Quasi-periodic pulsations (QPPs), which carry time features and plasma characteristics of flare emissions, are frequently observed in light curves of solar/stellar flares. In this study, we investigated non-stationary QPPs associated with recurrent jets during an M1.2 flare on 2022 July 14. A quasi-period of ∼45±10 s, determined by the wavelet transform technique, is simultaneously identified at wavelengths of soft/hard X-ray and microwave emissions, which are recorded by the Gravitational Wave High-Energy Electromagnetic Counterpart All-sky Monitor, Fermi and the Nobeyama Radio Polarimeters, respectively. A group of recurrent jets with an intermittent cadence of about 45 ± 10 s are found in the Atmospheric Imaging Assembly (AIA) image series at 304 Å, but they are 180 s earlier than the flare QPP. All observational facts suggest that the flare QPPs could be excited by recurrent jets, and they should be associated with non-thermal electrons that are periodically accelerated by a repeated energy release process, such as repetitive magnetic reconnection. Moreover, the same quasi-period is discovered at double footpoints connected by a hot flare loop in AIA 94 Å, and the phase speed is measured to be ∼1,420 km s−1. Based on the differential emission measure, the average temperatures, number densities, and magnetic field strengths at the loop top and footpoint are estimated to be ∼7.7/6.7 MK, ∼7.5/3.6 × 1010 cm−3, and ∼143/99 G, respectively. Our measurements indicate that the 45-s QPP is probably modulated by the kink-mode wave of the flare loop.</p

CEPC Technical Design Report -- Accelerator

International audienceThe Circular Electron Positron Collider (CEPC) is a large scientific project initiated and hosted by China, fostered through extensive collaboration with international partners. The complex comprises four accelerators: a 30 GeV Linac, a 1.1 GeV Damping Ring, a Booster capable of achieving energies up to 180 GeV, and a Collider operating at varying energy modes (Z, W, H, and ttbar). The Linac and Damping Ring are situated on the surface, while the Booster and Collider are housed in a 100 km circumference underground tunnel, strategically accommodating future expansion with provisions for a Super Proton Proton Collider (SPPC). The CEPC primarily serves as a Higgs factory. In its baseline design with synchrotron radiation (SR) power of 30 MW per beam, it can achieve a luminosity of 5e34 /cm^2/s^1, resulting in an integrated luminosity of 13 /ab for two interaction points over a decade, producing 2.6 million Higgs bosons. Increasing the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons, facilitating precise measurements of Higgs coupling at sub-percent levels, exceeding the precision expected from the HL-LHC by an order of magnitude. This Technical Design Report (TDR) follows the Preliminary Conceptual Design Report (Pre-CDR, 2015) and the Conceptual Design Report (CDR, 2018), comprehensively detailing the machine's layout and performance, physical design and analysis, technical systems design, R&D and prototyping efforts, and associated civil engineering aspects. Additionally, it includes a cost estimate and a preliminary construction timeline, establishing a framework for forthcoming engineering design phase and site selection procedures. Construction is anticipated to begin around 2027-2028, pending government approval, with an estimated duration of 8 years. The commencement of experiments could potentially initiate in the mid-2030s