Quantum correlations and classical resonances in an open chaotic system

We show that the autocorrelation of quantum spectra of an open chaotic system is well described by the classical Ruelle-Pollicott resonances of the associated chaotic strange repeller. This correspondence is demonstrated utilizing microwave experiments on 2-D n-disk billiard geometries, by determination of the wave-vector autocorrelation C(\kappa) from the experimental quantum spectra S_{21}(k). The correspondence is also established via "numerical experiments" that simulate S_{21}(k) and C(\kappa) using periodic orbit calculations of the quantum and classical resonances. Semiclassical arguments that relate quantum and classical correlation functions in terms of fluctuations of the density of states and correlations of particle density are also examined and support the experimental results. The results establish a correspondence between quantum spectral correlations and classical decay modes in an open systems.Comment: 10 pages, 5 eps figures, "Quantum chaos Y2K" Nobel symposium, to appear in Physica Script

Ising model on nonorientable surfaces: Exact solution for the Moebius strip and the Klein bottle

Closed-form expressions are obtained for the partition function of the Ising model on an M x N simple-quartic lattice embedded on a Moebius strip and a Klein bottle for finite M and N. The finite-size effects at criticality are analyzed and compared with those under cylindrical and toroidal boundary conditions. Our analysis confirms that the central charge is c=1/2.Comment: 8 pages, 3 eps figure

Mouthpart homologies and life habits of Mesozoic long-proboscid scorpionflies

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.Mesozoic long-proboscid scorpionflies (Mesopsychoidea) provide important clues to ancient plant-pollinator interactions. Among them, the family Aneuretopsychidae is especially important because its mouthparts are vital to deciphering the early evolution of Mesopsychoidea and putatively the origin of fleas (Siphonaptera). However, the identification of mouthpart homologs among Aneuretopsychidae remains controversial because of the lack of three-dimensional anatomical data. Here, we report the first Aneuretopsychidae from Late Cretaceous Burmese amber, which have short maxillary palpi and elongate mouthpart elements consisting of one pair of galeae and one hypopharynx. Their mouthparts are identical to those of Pseudopolycentropodidae (= Dualulidae, new synonym) but are not homologous to those of Siphonaptera. Our phylogenetic analysis provides robust evidence for the debated monophyly of Mesopsychoidea. Our results suggest that the long-proboscid condition has most likely evolved once in Mesopsychoidea, independently from fleas, and further reveal the variety and complexity of mid-Cretaceous pollinating insects

E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I

p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases. © 2013 Gao et al

ELUCID V. Lighting dark matter halos with galaxies

In a recent study, using the distribution of galaxies in the north galactic pole of SDSS DR7 region enclosed in a 500\mpch box, we carried out our ELUCID simulation (Wang et al. 2016, ELUCID III). Here we {\it light} the dark matter halos and subhalos in the reconstructed region in the simulation with galaxies in the SDSS observations using a novel {\it neighborhood} abundance matching method. Before we make use of thus established galaxy-subhalo connections in the ELUCID simulation to evaluate galaxy formation models, we set out to explore the reliability of such a link. For this purpose, we focus on the following a few aspects of galaxies: (1) the central-subhalo luminosity and mass relations; (2) the satellite fraction of galaxies; (3) the conditional luminosity function (CLF) and conditional stellar mass function (CSMF) of galaxies; and (4) the cross correlation functions between galaxies and the dark matter particles, most of which are measured separately for all, red and blue galaxy populations. We find that our neighborhood abundance matching method accurately reproduces the central-subhalo relations, satellite fraction, the CLFs and CSMFs and the biases of galaxies. These features ensure that thus established galaxy-subhalo connections will be very useful in constraining galaxy formation processes. And we provide some suggestions on the three levels of using the galaxy-subhalo pairs for galaxy formation constraints. The galaxy-subhalo links and the subhalo merger trees in the SDSS DR7 region extracted from our ELUCID simulation are available upon request.Comment: 18 pages, 13 figures, ApJ accepte

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis.

IntroductionEffective treatments for hormone-receptor-positive (HR(+)) breast cancer (BC) following relapse/progression on nonsteroidal aromatase inhibitor (NSAI) therapy are needed. Initial Breast Cancer Trials of OraL EveROlimus-2 (BOLERO-2) trial data demonstrated that everolimus and exemestane significantly prolonged progression-free survival (PFS) versus placebo plus exemestane alone in this patient population.MethodsBOLERO-2 is a phase 3, double-blind, randomized, international trial comparing everolimus (10 mg/day) plus exemestane (25 mg/day) versus placebo plus exemestane in postmenopausal women with HR(+) advanced BC with recurrence/progression during or after NSAIs. The primary endpoint was PFS by local investigator review, and was confirmed by independent central radiology review. Overall survival, response rate, and clinical benefit rate were secondary endpoints.ResultsFinal study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38-0.54); log-rank P < 0.0001; central review: 11.0 versus 4.1 months, respectively; hazard ratio = 0.38 (95% confidence interval 0.31-0.48); log-rank P < 0.0001] in the overall population and in all prospectively defined subgroups, including patients with visceral metastases, [corrected] and irrespective of age. The incidence and severity of adverse events were consistent with those reported at the interim analysis and in other everolimus trials.ConclusionThe addition of everolimus to exemestane markedly prolonged PFS in patients with HR(+) advanced BC with disease recurrence/progression following prior NSAIs. These results further support the use of everolimus plus exemestane in this patient population. ClinicalTrials.gov #NCT00863655