Evaluation of differences in the performance strategies of top and bottom basketball teams utilizing rank-sum ratio comprehensive

Introduction: This study aimed to explore common characteristics among top basketball teams, differentiate attacking and defensive performance between top and bottom teams, and correlate attacking and defensive performance with final competition rankings during the 2019 Men's Basketball World Cup, as well as to determine the relationship between performance indicators and the attacking and defensive performance. In addition, the study aimed to determine the attacking and defensive level of the top and bottom eight teams and find their existing problems and shortcomings, to further improve their competitive basketball strength, and also provided valid and reliable information for coaches to conduct targeted training in the future. Methods: The rank-sum ratio (RSR) was employed to evaluate the attack, defense, and overall attacking and defensive performance between the top and bottom teams during the 2019 Men's Basketball World Cup. Additionally, an independent sample T-test was conducted to test the difference in performance indicators of attack and defense between the top eight and bottom eight teams. Spearman Rho Correlation was conducted to determine the relationship between the attacking and defensive RSR value and the final competition ranking at the 0.05 confidence level. Pearson Correlation was employed to test the relationship between the performance indicators and the attacking and defensive RSR value at the 0.05 confidence level. According to Spearman and Pearson Correlation, the indicators which contributed most to the attacking and defensive performance, as well as the correlation between attack and defense and the final ranking, can thus be determined. Results: The results showed that the attacking performance of the top eight teams was far better than the bottom eight teams in terms of average points (p = 0.000), 2-point shoot percentage (p = 0.001), 3-point shoot percentage (p = 0.003), free throw percentage (p = 0.001), turnovers (p = 0.012), and assists (p = 0.000), and there was a significant difference (p 0.05), and the offensive rebounds of the bottom eight teams were better than the top eight teams. Additionally, there was a large gap between the top eight teams and the bottom eight teams in lost points (p = 0.001) and defensive rebounds (p = 0.000), with a very significant difference (p 0.05). Additionally, there was a very significant difference between attack RSR (p = 0.000), defense RSR (p = 0.006), and the overall attack-defense RSR (p = 0.000) of the top eight and bottom eight teams (p < 0.01), and most top teams focused on developing both attack and defense and paid attention to improve the overall attacking and defensive ability. Moreover, there was a significant relationship between the overall attack-defense performance and assists (p = 0.832), rebounds (p = 0.762), turnovers (p = 0.702), 2-point shoot percentage (p = 0.704), defensive rebounds (p = 0.809), fast-break points (p = 0.577), blocks (p = 0.600), and free throw percentage (p = 0.575). Conclusions: This study showed that the top basketball teams focused on developing both attack and defense, and have the common characteristics of strong attack and defense. Whether it was the attack, defense, or overall attacking and defensive ability, there was a significant relationship with the final ranking. Additionally, this study showed that there were very significant differences in both attacking and defensive abilities between the top eight and bottom eight teams, as well as highlighted their respective advantages and disadvantages in attacking and defensive indicators. Besides that, this study found that performance indicators such as assists, defensive rebounds, 2P%, turnovers, FT%, fast-breaks, and blocks were the main factors that distinguish the top and bottom teams, and they had a significant relationship with overall attacking and defensive performance. The above information allows coaches and players to learn the latest developments in competitive basketball, as well as their advantages and disadvantages, to help them organize targeted training in the future

Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma

Abstract Background Lung adenocarcinoma (LUAD), largely remains a primary cause of cancer-related death worldwide. The molecular mechanisms in LUAD metastasis have not been completely uncovered. Methods In this study, we identified differentially expressed genes (DEGs), miRNAs (DEMs) and lncRNAs (DELs) underlying metastasis of LUAD from The Cancer Genome Atlas database. Intersection mRNAs were used to perform gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and co-expression network analysis. In addition, survival analyses of intersection mRNAs were conducted. Finally, intersection mRNAs, miRNAs and lncRNAs were subjected to construct miRNA-mRNA-lncRNA network. Results A total of 1015 DEGs, 54 DEMs and 22 DELs were identified in LUAD metastasis and non-metastasis samples. GO and KEGG pathway analysis had proven that the functions of intersection mRNAs were closely related with many important processes in cancer pathogenesis. Among the co-expression interactions network, 22 genes in the co-expression network were over the degree 20. These genes imply that they have connections with many other gene nodes. In addition, 14 target genes (ARHGAP11A, ASPM, HELLS, PRC1, TMPO, ARHGAP30, CD52, IL16, IRF8, P2RY13, PRKCB, PTPRC, SASH3 and TRAF3IP3) were found to be associated with survival in patients with LUAD significantly (log-rank P < 0.05). Two lncRNAs (LOC96610 and ADAM6) acting as ceRNAs were identified based on the miRNA-mRNA-lncRNA network. Conclusions Taken together, the results may provide a novel perspective to develop a multiple gene diagnostic tool for LUAD prognosis, which might also provide potential biomarkers or therapeutic targets for LUAD

Selective hydrogenation of butyl levulinate to gamma-valerolactone over sulfonated activated carbon-supported SnRuB bifunctional catalysts

The synthesis of gamma-valerolactone (GVL) from butyl levulinate (BL) hydrogenation over sulfonated activated carbon (SAC) supported SnRuB bifunctional catalysts was studied. These catalysts were characterized by ICP, nitrogen physisorption, XRD, HRTEM, XPS and NH3-TPD techniques. The SnRuB hydrogenation active site and surface acidic site of the SAC support are effectively retained by the co-impregnation followed by a chemical reduction process and display a prominent synergetic effect for BL hydrogenation to GVL. Under the optimal reaction conditions (180 degrees C, 3 MPa, 800 rpm, 3 h), BL conversion of 99.2% and GVL selectivity of 83.8% were obtained over the optimal 20Sn1RuB/SAC catalyst. The highest total fraction of the C=O group, lattice oxygen (O-alpha) and oxygen vacancies (O-beta) and active SnOx, species on the surface of the catalyst contribute to the best adsorption and hydrogenation ability for BL conversion to GVL over the 20Sn1RuB/SAC catalyst. The sulfonated carbon-supported SnRuB bifunctional catalyst also showed outstanding recyclability in six runs due to enhanced reduction degree of Snn+ species, and strong interaction between the SnRuB active site and SAC support. In sum, the sulfonated carbon-supported SnRuB bifunctional catalyst with Low costs, high activity and good recyclability is a potential candidate for butyl levulinate hydrogenation to GVL

Diversity of platinum-sites at platinum/fullerene interface accelerates alkaline hydrogen evolution

One major technological obstacle for membrane-based alkaline water electrolyzer is the inefficient hydrogen evolution reaction. Here, the authors report a platinum/fullerene heterostructure catalyst, which shows enhanced activity for hydrogen production due to the diverse interface between platinum and fullerene

FABP6 Expression Correlates with Immune Infiltration and Immunogenicity in Colorectal Cancer Cells

Background. Immune checkpoint inhibitors (ICIs) have rapidly revolutionized colorectal cancer (CRC) treatment, but resistance caused by the heterogeneous tumor microenvironment (TME) still presents a challenge. Therefore, it is necessary to characterize TME immune infiltration and explore new targets to improve immunotherapy. Methods. The compositions of 64 types of infiltrating immune cells and their relationships with CRC patient clinical characteristics were assessed. Differentially expressed genes (DEGs) between “hot” and “cold” tumors were used for functional analysis. A prediction model was constructed to explore the survival of CRC patients treated with and without immunotherapy. Finally, fatty acid-binding protein (FABP6) was selected for in vitro experiments, which revealed its roles in the proliferation, apoptosis, migration, and immunogenicity of CRC tissues and cell lines. Results. The infiltration levels of several immune cells were associated with CRC tumor stage and prognosis. Different cell types showed the synergistic or antagonism infiltration patterns. Enrichment analysis of DEGs revealed that immune-related signaling was significantly activated in hot tumors, while metabolic process pathways were altered in cold tumors. In addition, the constructed model effectively predicted the survival of CRC patients treated with and without immunotherapy. FABP6 knockdown did not significantly alter tumor cell proliferation, apoptosis, and migration. FABP6 was negatively correlated with immune infiltration, and knockdown of FABP6 increased major histocompatibility complex (MHC) class 1 expression and promoted immune-related chemokine secretion, indicating the immunogenicity enhancement of tumor cells. Finally, knockdown of FABP6 could promote the recruitment of CD8+ T cells. Conclusion. Collectively, we described the landscape of immune infiltration in CRC and identified FABP6 as a potential immunotherapeutic target for treatment

Efficacy and Safety Profile of Combining Vandetanib with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

<div><p>Objective</p><p>To evaluate the efficacy and safety profile of combining vandetanib with chemotherapy in patients with advanced non-small cell lung cancer (NSCLC).</p><p>Methods</p><p>MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), ASCO Abstracts, ESMO Abstracts, Wanfang Database, CNKI were searched. Eligible studies were the randomized clinical trials (RCTs) that compared the efficacy and safety profile of adding vandetanib to chemotherapy with single chemotherapy in patients with advanced NSCLC. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities. All meta-analysis were performed using Review Manager 5.1. The fixed-effect model weighted by the Mantel-Haenszel method was used. When considerable heterogeneity was found (<i>p</i><0.1, or I²>50%), further analysis (subgroup analysis, sensitivity analysis or random-effect model) was performed to identify potential cause.</p><p>Results</p><p>Results reported from 5 RCTs involving 2284 patients were included in the analysis. Compared to chemotherapy alone, the addition of vandetanib resulted in a significant longer PFS (HR 0.79 [0.72–0.87], <i>p</i><0.00001) and a higher ORR (RR 1.75 [1.43–2.15], <i>p</i><0.00001), but failed to show advantage on OS (HR 0.96 [0.87–1.06], <i>p</i> = 0.44).</p><p>Conclusion</p><p>Vandetanib has activity in NSCLC. Identification of predictive biomarkers is warranted in future trials to select a subset of patients with advanced NSCLC who may benefit from vandetanib.</p></div

A Shark Liver Gene-Derived Active Peptide Expressed in the Silkworm, Bombyx mori: Preliminary Studies for Oral Administration of the Recombinant Protein

Abstract: Active peptide from shark liver (APSL) is a cytokine from Chiloscyllium plagiosum that can stimulate liver regeneration and protects the pancreas. To study the effect of orally administered recombinant APSL (rAPSL) on an animal model of type 2 diabetes mellitus, the APSL gene was cloned, and APSL was expressed in Bombyx mori N cells (BmN cells), silkworm larvae and silkworm pupae using the silkworm baculovirus expression vector system (BEVS). It was demonstrated that rAPSL was able to significantly reduce the blood glucose level in mice with type 2 diabetes induced by streptozotocin. The analysis of paraffin sections of mouse pancreatic tissues revealed thatMar. Drugs 2013, 11 1493 rAPSL could effectively protect mouse islets from streptozotocin-induced lesions. Compared with the powder prepared from normal silkworm pupae, the powder prepared from pupa

Flow chart for identification and inclusion of trials for this meta-analysis.

<p>Flow chart for identification and inclusion of trials for this meta-analysis.</p

Funnel plot to assess for evidence of publication bias.

<p>Funnel plot to assess for evidence of publication bias.</p

Comparison of OS between addition of vandetanib to chemotherapy and chemotherapy alone.

<p>Comparison of OS between addition of vandetanib to chemotherapy and chemotherapy alone.</p