The Wound Healing Responses and Corneal Biomechanics after Keratorefractive Surgery

Corneal biomechanics have been concerned recently since it is not only found to play an important role in the wound healing process after corneal refractive surgeries, but also essential to improve the predictability and safety of refractive procedures. Corneal biomechanics and wound healing responses are linked in time and space and may also cause complications of keratectasia, haze formation, and regression. This review focuses on wound healing and biomechanics of the corneal refractive procedures. Identifying corneal wound healing from the biomechanical point of view is mandatory to improve the outcomes and reduce the complications

CarDD: A New Dataset for Vision-based Car Damage Detection

Automatic car damage detection has attracted significant attention in the car insurance business. However, due to the lack of high-quality and publicly available datasets, we can hardly learn a feasible model for car damage detection. To this end, we contribute with the Car Damage Detection (CarDD), the first public large-scale dataset designed for vision-based car damage detection and segmentation. Our CarDD contains 4,000 high-resolution car damage images with over 9,000 wellannotated instances of six damage categories (examples are shown in Fig. 1). We detail the image collection, selection, and annotation processes, and present a statistical dataset analysis. Furthermore, we conduct extensive experiments on CarDD with state-of-theart deep methods for different tasks and provide comprehensive analysis to highlight the specialty of car damage detection

Transcriptome Sequencing of Solanum Nigrum Linn Reveals the Genes Related to the Biosynthesis of Flavonoids

In this work we comprehensively compared the transcriptome profiles of ripe fruits (RFs) and unripe fruits (UFs) and identified the genes related to flavonoid biosynthesis in Solanum nigrum Linn. (S. nigrum). Firstly, 118198 unigenes with a N50 length of 1339 bp were de novo assembled. In addition, 527 genes that were differential expression in RFs and UFs have been identified, including 329 down-regulated genes and 198 up-regulated genes. Especially, 8 differential expression genes (DEGs) were identified to be involved in flavonoid biosynthesis. Coincidentally, most of the 8 flavonoid-related genes were highly expressed in RFs. Finally, we found that the differential expression of three genes that were related to the synthesis of dihydroflavonol-4-reductase (DFR), flavonoid 3’, 5’-hydroxylase (F35H) and anthocyanin synthase (ANS) was the main reason for differences in flavonoid biosynthesis between RFs and UFs of S. nigrum. This study provides some supporting information for the flavonoid accumulation in RFs. Moreover, this study can improve our understanding of the molecular mechanisms of flavonoid biosynthesis in S. nigrum

Economic Analysis on Experiences of Western Auto Industry to Hubei’s Low Carbon Auto Development in the Post Crisis Era

It is expected that by 2020, the saving and new energy car production in Hubei will reach 600 thousand, the predicted sales will reach 500 thousand. As one of the three major automobile bases in China, Green cars, long popular in European countries such as Belgium, has therefore become a key for both the revival and the low carbon development of Hubei’s auto industry. Analyzing the green car development in Europe and the history of the US auto’s once prosperity, its gradual decline and the latest green development, the paper holds the view that, in the Post Financial Crisis Era, the biggest opportunity for Hubei’s auto industry lies in the low carbon development. Key words: Saving and new energy vehicles; US auto financing; Belgian “green” car plastics; Hubei low carbon development; Post crisis er

Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer.

Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial. For example, overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer. In contrast, amplification of DYRK2 gene occurs in esophageal/lung adenocarcinoma, implying the role of DYRK2 as a potential oncogene. However, its clinical role in colorectal cancer (CRC) has not been explored. In this study, we analyzed the expression of DYRK2 from Oncomine database and found that DYRK2 level is lower in primary or metastatic CRC compared to adjacent normal colon tissue or non-metastatic CRC, respectively, in 6 colorectal carcinoma data sets. The correlation between DYRK2 expression and clinical outcome in 181 CRC patients was also investigated by real-time PCR and IHC. DYRK2 expression was significantly down-regulated in colorectal cancer tissues compared with adjacent non-tumorous tissues. Functional studies confirmed that DYRK2 inhibited cell invasion and migration in both HCT116 and SW480 cells and functioned as a tumor suppressor in CRC cells. Furthermore, the lower DYRK2 levels were correlated with tumor sites (P = 0.023), advanced clinical stages (P = 0.006) and shorter survival in the advanced clinical stages. Univariate and multivariate analyses indicated that DYRK2 expression was an independent prognostic factor (P < 0.001). Taking all, we concluded that DYRK2 a novel prognostic biomarker of human colorectal cancer

Sustainable development in natural resources industry: is geopolitical risk a catalyst for corporate excess cash holdings?

With the outbreak of the Russia-Ukraine conflict, combined with the COVID-19 epidemic and the Federal Reserve’s interest rate hike, geopolitical risks have increased sharply, which has brought great pressure on the sustainable development of natural resources industry. This study aims to discuss the impact of geopolitical risk (GPR) on corporate excess cash holdings in China’s natural resources industry. The findings suggest that GRP can encourage enterprises in the natural resources industry to hold more excess cash. The findings still hold with a suite of robustness tests. The study also evidences that the above effect is more significant for state-owned enterprises, enterprises in the mining industry, and large-scale enterprises. Finally, further results show that with the increase of GPR, enterprises with strong risk-taking capacity tend to hold more excess cash, while enterprises registered in higher market-oriented regions are inclined to retain less excess cash. These findings can conduce to a deep understanding of the influence of GPR on corporate excess cash holdings and serve as a reference for policy-makers to adjust policies