Evidence for a soft-phonon-mode-driven Peierls-type distortion in Sc3_3CoC4_4

We provide experimental and theoretical evidence for the realization of the Peierls-type structurally distorted state in the quasi-one-dimensional superconductor Sc$_3$CoC$_4$ by a phonon-softening mechanism. The transition from the high- to the final low-temperature phase below 80K proceeds via an extended intermediate temperature regime between 80K and 150K characterized by phonon-driven atom displacements. In support of the low-dimensional character of the title compound we find a highly anisotropic correlation-length of these dynamic distortions.Comment: 9 pages, 7 figures and supporting informatio

Audio Resynthesis on the Dancefloor: A Music Structural Approach

This technical report improves and extends existing methods in the research area of audio resynthesis and retargeting and extends its usage scopes. The existing approach analyzes a musical piece for possible cut points that allow the resynthesis of a novel soundtrack by lining up the source segments according to specified rules. For the improvement of matching harmonic and rhythmic structures during cut points search, beat tracking is used as core component of this work. Segment rearrangement is improved by employing faster and better suited algorithms

Aquilegia, Vol. 33 No. 2, Summer 2009, Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1128/thumbnail.jp

Limited predictive value of FDG-PET for response assessment in the preoperative treatment of esophageal cancer : results of a prospective multi-center trial (SAKK 75/02)

BACKGROUND: Only responding patients benefit from preoperative therapy for locally advanced esophageal carcinoma. Early detection of non-responders may avoid futile treatment and delayed surgery. PATIENTS AND METHODS: In a multi-center phase ll trial, patients with resectable, locally advanced esophageal carcinoma were treated with 2 cycles of induction chemotherapy followed by chemoradiotherapy (CRT) and surgery. Positron emission tomography with 2[fluorine-18]fluoro-2-deoxy-d-glucose (FDG-PET) was performed at baseline and after induction chemotherapy. The metabolic response was correlated with tumor regression grade (TRG). A decrease in FDG tumor uptake of less than 40% was prospectively hypothesized as a predictor for histopathological non-response (TRG < 2) after CRT. RESULTS: 45 patients were included. The median decrease in FDG tumor uptake after chemotherapy correlated well with TRG after completion of CRT (p = 0.021). For an individual patient, less than 40% decrease in FDG tumor uptake after induction chemotherapy predicted histopathological non-response after completion of CRT, with a sensitivity of 68% and a specificity of 52% (positive predictive value 58%, negative predictive value 63%). CONCLUSIONS: Metabolic response correlated with histopathology after preoperative therapy. However, FDG-PET did not predict non-response after induction chemotherapy with sufficient clinical accuracy to justify withdrawal of subsequent CRT and selection of patients to proceed directly to surgery

HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa

Background: Many mathematical models have investigated the impact of expanding access to antiretroviral therapy (ART) on new HIV infections. Comparing results and conclusions across models is challenging because models have addressed slightly different questions and have reported different outcome metrics. This study compares the predictions of several mathematical models simulating the same ART intervention programmes to determine the extent to which models agree about the epidemiological impact of expanded ART. Methods and Findings: Twelve independent mathematical models evaluated a set of standardised ART intervention scenarios in South Africa and reported a common set of outputs. Intervention scenarios systematically varied the CD4 count threshold for treatment eligibility, access to treatment, and programme retention. For a scenario in which 80% of HIV-infected individuals start treatment on average 1 y after their CD4 count drops below 350 cells/µl and 85% remain on treatment after 3 y, the models projected that HIV incidence would be 35% to 54% lower 8 y after the introduction of ART, compared to a counterfactual scenario in which there is no ART. More variation existed in the estimated long-term (38 y) reductions in incidence. The impact of optimistic interventions including immediate ART initiation varied widely across models, maintaining substantial uncertainty about the theoretical prospect for elimination of HIV from the population using ART alone over the next four decades. The number of person-years of ART per infection averted over 8 y ranged between 5.8 and 18.7. Considering the actual scale-up of ART in South Africa, seven models estimated that current HIV incidence is 17% to 32% lower than it would have been in the absence of ART. Differences between model assumptions about CD4 decline and HIV transmissibility over the course of infection explained only a modest amount of the variation in model results. Conclusions: Mathematical models evaluating the impact of ART vary substantially in structure, complexity, and parameter choices, but all suggest that ART, at high levels of access and with high adherence, has the potential to substantially reduce new HIV infections. There was broad agreement regarding the short-term epidemiologic impact of ambitious treatment scale-up, but more variation in longer term projections and in the efficiency with which treatment can reduce new infections. Differences between model predictions could not be explained by differences in model structure or parameterization that were hypothesized to affect intervention impact

System size dependence of cluster properties from two-particle angular correlations in Cu+Cu and Au+Au collisions at sNN\sqrt{s_{_{NN}}} = 200 GeV

We present results on two-particle angular correlations in Cu+Cu and Au+Au collisions at a center of mass energy per nucleon pair of 200 GeV over a broad range of pseudorapidity ($\eta$) and azimuthal angle ($\phi$) as a function of collision centrality. The PHOBOS detector at RHIC has a uniquely-large angular coverage for inclusive charged particles, which allows for the study of correlations on both long- and short-range scales. A complex two-dimensional correlation structure in $\Delta \eta$ and $\Delta \phi$ emerges, which is interpreted in the context of a cluster model. The effective cluster size and decay width are extracted from the two-particle pseudorapidity correlation functions. The effective cluster size found in semi-central Cu+Cu and Au+Au collisions is comparable to that found in proton-proton collisions but a non-trivial decrease of the size with increasing centrality is observed. Moreover, a comparison between results from Cu+Cu and Au+Au collisions shows an interesting scaling of the effective cluster size with the measured fraction of total cross section (which is related to the ratio of the impact parameter to the nuclear radius, $b/2R$), suggesting a geometric origin. Further analysis for pairs from restricted azimuthal regions shows that the effective cluster size at $\Delta\phi \sim 180^{\circ}$ drops more rapidly toward central collisions than the size at $\Delta\phi \sim 0^{\circ}$. The effect of limited $\eta$ acceptance on the cluster parameters is also addressed, and a correction is applied to present cluster parameters for full $\eta$ coverage, leading to much larger effective cluster sizes and widths than previously noted in the literature. These results should provide insight into the hot and dense medium created in heavy ion collisions.Comment: 9 pages, 8 figures, Published in Phys. Rev.