8 research outputs found
Palladium-Catalyzed Four-Component Cascade Reaction for the Synthesis of Highly Functionalized Acyclic <i>O</i>,<i>O</i>‑Acetals
A palladium-catalyzed four-component
cascade reaction of carbon
dioxide, amines, allenyl ethers, and aryl iodides has been developed
for the first time. The novel reaction allows simultaneous construction
of three different new bonds (C–N, C–O, and C–C)
in a single step, affording an efficient method for the synthesis
of a variety of highly functionalized acyclic <i>O</i>,<i>O</i>-acetals. Excellent chemo- and regioselectivity, wide substrate
scope, and good functional group tolerance are features of the method
Copper-Catalyzed [4 + 1] Annulation between α‑Hydroxy Ketones and Nitriles: An Approach to Highly Substituted 3(2<i>H</i>)‑Furanones
A copper-catalyzed
[4 + 1] annulation between α-hydroxy ketones
and nitriles has been developed. The reaction provides a facile and
efficient method for the construction of a wide range of highly substituted
3Â(2<i>H</i>)-furanones, a class of important compounds known
to be associated with several biological activities
Palladium-Catalyzed Oxidative C–N Bond Coupling Involving a Solvent-Controlled Regioselective Bromination Process
Stereoselective
palladium-catalyzed oxidative C–N bond coupling
reactions between aromatic amines and alkenes involving a solvent-controlled
regioselective bromination process under 1 atm of oxygen atmosphere
are disclosed, providing easy access to two different brominated enamines.
The addition of hydrogen peroxide (30% aq) as a co-oxidant in the
system is crucial for the dehydrogenative aminohalogenation under
molecular oxygen (1 atm), and in such a case, the C–N bond
coupling/electrophilic bromination reaction cascade is proposed. Furthermore,
the different reaction media leads to a switched regioselectivity
of the process
Base-Promoted Formal [4 + 3] Annulation between 2<i>-</i>FluoroÂphenylÂacetylenes and Ketones: A Route to Benzoxepines
The
first base-promoted formal [4 + 3] annulation between 2-fluorophenylÂacetylenes
and ketones has been disclosed. The reaction proceeds through a tandem
α-vinylation of ketones followed by an intramolecular nucleophilic
aromatic substitution (S<sub>N</sub>Ar) reaction of the <i>in
situ</i> generated β,γ-unsaturated ketone intermediates,
providing a straightforward access to a wide range of functionalized
benzoxepines in moderate to high yields. The transition-metal-free
methodology featured a wide substrate scope, the use of easily available
starting materials, and a high functional group tolerance
Palladium-Catalyzed Synthesis of 1<i>H</i>‑Indenes and Phthalimides via Isocyanide Insertion
A new and versatile multicomponent
domino strategy has been developed
for the synthesis of a series of 1<i>H</i>-indene and phthalimide
derivatives from simple and readily available starting materials.
This process operating under mild conditions shows a broad substrate
scope with moderate to excellent yields
Base-Promoted Formal [4 + 3] Annulation between 2<i>-</i>FluoroÂphenylÂacetylenes and Ketones: A Route to Benzoxepines
The
first base-promoted formal [4 + 3] annulation between 2-fluorophenylÂacetylenes
and ketones has been disclosed. The reaction proceeds through a tandem
α-vinylation of ketones followed by an intramolecular nucleophilic
aromatic substitution (S<sub>N</sub>Ar) reaction of the <i>in
situ</i> generated β,γ-unsaturated ketone intermediates,
providing a straightforward access to a wide range of functionalized
benzoxepines in moderate to high yields. The transition-metal-free
methodology featured a wide substrate scope, the use of easily available
starting materials, and a high functional group tolerance
Pd-Catalyzed Highly Regio- and Stereoselective Formation of C–C Double Bonds: An Efficient Method for the Synthesis of Benzofuran‑, Dihydrobenzofuran‑, and Indoline-Containing Alkenes
A highly regio- and
stereoselective C–C double bond formation
reaction via Pd-catalyzed Heck-type cascade process with <i>N</i>-tosylhydrazones has been developed. Various <i>N</i>-tosylhydrazones
derived from both ketones and aldehydes are found to be efficient
substrates to provide di- and trisubstituted olefins with high regio-
and stereoselectivity. Furthermore, this reaction has a good functional
group tolerance and different benzofuran-, dihydrobenzofuran-, and
indoline-containing alkene products were obtained with high selectivity
Palladium-Catalyzed Synthesis of 1<i>H</i>‑Indenes and Phthalimides via Isocyanide Insertion
A new and versatile multicomponent
domino strategy has been developed
for the synthesis of a series of 1<i>H</i>-indene and phthalimide
derivatives from simple and readily available starting materials.
This process operating under mild conditions shows a broad substrate
scope with moderate to excellent yields